Kaffetin

Description overdue on 10/20/2014

• Latin name: Caffetin
• ATC code: N02BE71
• Active substance: Codeine + Paracetamol + Caffeine + propyphenazone (Codeine + Caffeine + Paracetamol + Propyphenazone)
• Manufacturer: Alkaloid AD, Republic of Macedonia

Photos of the drug

Tweet

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Kaffetina (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Reviews
• Price, where to buy

Composition Kaffetina

The composition Kaffetina (1 tablet) as active substances included 250 mg paracetamol 210 mg   propyphenazone 50 mg caffeine   and 10 mg Codeine phosphate sesquihydrate .

As auxiliary substances included in the composition Kaffetina 6, 3 mg glyceryl dibehenate , 21, 1 mg calcium hydrogenphosphate dihydrate 14, 5 mg sodium carboxymethyl starch 2, 5 mg colloidal anhydrous silica, 9, 6 mg croscarmellose sodium 13 mg magnesium stearate 5, 1, 5 mg of sodium lauryl sulfate, 12, 5 and 28 mg Povidone 5 mg microcellulose.

Product form

The drug comes in the form of round, flat white tablets with a facet in which one side is engraved "5", and the other engraved with the inscription «CAFFETIN».

Lay 6 or 10 tablets in a perforated strip of aluminum or plastic foil. Then placed in cardboard boxes on the Strip 1 (if there 10 tablets) or two strips (if each of them six tablets).

Pharmacological action

Kaffetin has stimulating effect , Analgesic, reduces fever, and his peculiar antitussive and anti-inflammatory influence.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Kaffetin is a combination drug, its effect is determined by the action of the components that are part of the drug:

• The presence of paracetamol   due antipyretic and analgesic effect of the drug.
• Caffeine   is responsible for the stimulation provided   psychomotor centers of the brain , Choose analeptic action , Increasing effect analgesics , Reducing sleepiness and fatigue, increase mental and physical performance, increase heart rate , Increasing Blood Pressure   conditions in the presence of hypotension . Besides that, caffeine   able to improve the absorption of other active ingredients of medicines.
• Action codeine   due antitussive effect That occurs due to suppression of the central nervous system neuronal excitability cough center . Codeine also exerts analgesic effect , Arousing opiate receptors Located in different parts of the central nervous system and in peripheral tissues. It stimulates antinociceptive system   and changes the emotional perception of pain.
• Propyphenazone   painkillers and has antipyretic effect . Analgesic effect is achieved in 30-60 minutes, and a duration of effect of 4-8 hours.

Pharmacokinetics

Paracetamol   very quickly absorbed. Maximum plasma concentration is reached at 0, 5-2 hours after ingestion. It has the property to penetrate the blood-brain barrier. Metabolism occurs in the liver in three main ways: by conjugation to glucuronide conjugation with sulphates or by oxidation due to the action microsomal liver enzymes . In the case of the oxidation of the formation of toxic intermediate metabolites. These metabolites are then joined in the conjugate   glutathione .

If there is a shortage in the body glutathione Such metabolites can cause damage and death of liver cells. The half-life takes 1-4 hours. Excreted through the kidneys in the form of metabolic substances, mostly in the form of conjugates.

Caffeine well absorbed, and the absorption occurs throughout the intestine. The maximum plasma concentration occurs within 50-75 minutes after taking the drug inside. Caffeine tend to rapid distribution to all organs and tissues of the body; it is fairly easy to penetrate through blood-brain barrier   and placenta . More than 90% of the caffeine is metabolized in the liver. The half-life is 3, 9-5, 3 hours. Elimination from the body is carried out by the kidneys.

Codeine quickly absorbed. Maximum plasma concentration is achieved in 2-4 hours. Metabolism occurs in the liver - active metabolites formed. Elimination from the body is produced by the kidneys, and excreted in the bile. The half-life is a 2, 5-4 hours.

Propyphenazone   rapidly absorbed in the gastrointestinal tract. The maximum concentration in plasma after about 0, 5-0, 6 hours after ingestion. Metabolism occurs in the liver. Excreted from the body through the allocation of urine or bile. The half-life is 2, 1-2, 4 hours.

Indications

The drug is indicated for use in the presence of pain   moderate severity, which may have various origins.

Kaffetin use at:

• headache and toothache;
• migraine ;
• neuralgia ;
• myalgia ;
• post-traumatic pain ;
• arthralgia ;
• algodismenorei .

Contraindications

Contraindications may be the presence of the patient:

• hypersensitivity;
• hepatic   or renal failure ;
• leukopenia ;
• hemodyscrasia;
• anxiety disorders   ( agoraphobia . panic disorders );
• organic diseases of the cardiovascular system (including acute myocardial infarction . atherosclerosis . angina ) Arrhythmia . hypertension ;
• deficit glucose-6-phosphate dehydrogenase ;
• sleep disorders;
• pregnancy;
• lactation;
• under 18 years of age.

Caution should be exercised when:

• acute abdominal pain at some unknown reason, this pain;
• attack asthma ;
• chronic obstructive pulmonary disease ;
• convulsions;
• drug addiction (including at the mention of it in history);
• alcoholism ;
• increased excitability;
• benign   hyperbilirubinemia   (eg,   Gilbert's syndrome );
• viral hepatitis ;
• glaucoma ;
• in old age.

If the patient is present above a disease or condition, consultation with a doctor is required.

Side effects

Kaffetin tablets may have side effects on some systems of the body:

• Nervous system and sense organs : Increased excitability may occur tremor , Anxiety, insomnia.
• Cardiovascular system : Heart palpitations, increased Blood Pressure .
• Digestive system : May be exacerbated peptic ulcer , Increase the activity hepatic transaminases , Nausea, vomiting.
• Allergic and immune reactions : Relatively rare in occurrence of skin rash, hives , Itching, swelling of the face,   bronchospasm , Laryngeal edema, laryngospasm   or angioedema .
• Hematopoietic system : Occasionally may develop anemia, thrombocytopenia, methemoglobinemia, leukopenia, agranulocytosis.

If the patient has any of the above listed possible side effects seen too sharply or there are any other side effects should be reported to your doctor.

Instructions for use Kaffetina (method and dosage)

Instructions on Kaffetin involves the use of the drug inside.

Assign 1 tablet 3-4 times per day to adults. In the presence of severe pain it is recommended taking 2 tablets at once. The maximum dose of the drug, which can be taken during the day - 6 tablets.

Do not take the drug for more than 5 days. Increase daily dose or duration of treatment is possible only in case of doctor's recommendation.

Overdose

Each active substance, which is part of the preparation, may cause specific symptoms.

• Paracetamol : The first 24 hours after ingestion - skin turns pale, may cause nausea, vomiting,   abdominal pain ; impaired glucose metabolism, develops metabolic acidosis . Symptoms associated with impaired liver function, may occur after 12-48 hours after ingestion.
• Caffeine : It may be anxiety, may occur tremor , Headaches, confusion, arrythmia .
• Codeine : The appearance of a cold clammy sweat, confusion, dizziness, drowsiness, reduced Blood Pressure , Signs of nervousness, fatigue, development bradycardia , Severe weakness, shortness of breath slow, Hypothermia . anxiety . miosis , Seizures.

In case of overdose the stomach washed appoint Activated carbon Support heart function and level Blood Pressure , Supportive therapy. Intravenous impose specific antagonist of opioid analgesics - Naloxone . Also introduced donators of SH-groups   synthetic substances and precursors glutathione   - Methionine   for a period of about 8-9 hours after administration and acetylcysteine   - For 8 hours.

If you suspect poisoning, be sure to immediately contact the medical facility.

Cooperation

Caffeine

• the combined use of caffeine barbiturates . anticonvulsant drugs   It may result in increased metabolism and increased clearance of caffeine;
• simultaneously with the application of Cimetidine, oral contraceptive drugs, disulfiram, ciprofloxacin, norfloxacin   It reduces the caffeine metabolism produced by the liver;
• reduced force effect of narcotic and hypnotic drugs;
• the combined use of caffeine and beta-blockers may lead to mutual reduce therapeutic effects;
• mix with adrenergic bronchodilators drugs   causing additional stimulation of the central nervous system;
• accelerated absorption ergotamine ;
• combination   monoamine oxidase inhibitors   and large doses of caffeine can cause dangerous heart arrhythmias   or a significant increase in Blood Pressure ;
• the effects of caffeine can reduce clearance   theophylline   and other xanthine .

Codeine

• simultaneous use with codeine ethanol, muscle relaxants As well as drugs depress the central nervous system can lead to increased sedation, inhibition of the respiratory center and central nervous system depression;
• combination with drugs with anticholinergic activity , Antidiarrheal drugs increases the risk of constipation;
• reduced effect Metoclopramide .

Paracetamol

• reception inducers of microsomal oxidation Which occurs in the liver (i.e., anticonvulsant drugs barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants ) ethanol   and hepatotoxic drugs increases the production of hydroxylated active metabolic products, which can lead to severe toxicity, even at relatively small overdose;
• simultaneous administration of high doses of acetaminophen can lead to increased steps anticoagulants (these are derivatives Bishydroxycoumarin );
• reduced effect uricosuric drugs ;
• myelotoxicity drugs   gematotoksichnosti reinforce the possible manifestations of the drug;
• Paracetamol 5 times increased half-life chloramphenicol ;
• Metoclopramide   can accelerate the absorption of paracetamol.

Terms of sale

Sell ​​only with a prescription.

Storage conditions

Store Kaffetin at ot15 ° C to 25 ° C.

Shelf life

3 years.

Cautions

Prior consultation with the doctor can not take the drug for more than 5 days. In the case of long-term (longer than 1 week) necessary to control the use of peripheral blood picture   and to monitor the functional state of the liver.

At the time when the drug is used, it is necessary to stop the use of ethanol (as this increases the risk of hepatotoxicity action).

In laboratory studies, distorted figures obtained for the quantitative determination of sugar, as well as Uric acid   in blood plasma.

Use of the drug can lead to a change in the results of analyzes of doping control in athletes and prevent the establishment of a diagnosis acute abdominal pain .

Reviews Kaffetine

Reviews Kaffetine show that the drug is really effective. Side effects manifested (most often in the form of a small dizziness or nausea), but not in all cases.

Price Kaffetina where to buy

Buy in Moscow Kaffetin can be in almost any drugstore. Price Kaffetina (pack of 12 tablets) is about 115 rubles.

Get the best price and buy