Description overdue on 09.10.2011
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The preparation Irunine It is a synthetic antifungal Which has a fairly wide range of effects. This medication is able to very effectively inhibit the synthesis of ergosterol in the cell membrane of fungi. It applies to dermatophytes, yeasts in the Candida Spp, molds. In the case of mycosis efficacy of this drug can be evaluated not earlier than the two to four weeks after cessation of treatment. Patients onychomycosis effect appears after 6-9 months, when the change takes place nails.
Indications and methods of use of the drug:
Irunine prescribed for fungal infections of the skin and mucous membranes of the eyes and mouth, with tropical mycosis; indication for use of the drug is vulvovaginal candidiasis Provoked by dermatophytes or yeasts onychomycosis , System aspergillosis . cryptococcosis . Also take medication at histoplasmosis . blastomycosis . sporotrichosis . paracoccidioidomycosis , Lesions of pityriasis versicolor.
Irunine The drug is taken orally after meal is over. Vulvovaginal candidiasis patients must take twice daily 200 mg dose in one day or 200 mg taken once a day for three consecutive days. Patients with pityriasis versicolor take mgirunina 200 a day for seven days. When ringworm should take 100 mg once a day for 15 days. A similar dose for 15 days must be taken in the defeat of the skin of hands and feet. Candidiasis of the oral mucosa once per day should take 100 mg for 15 days. Patients with fungal keratitis Irunine take 200mg once daily for 21 days . When onychomycosis - 200 mg per day should be taken for three months . In the case of repeated courses of the drug you need to take 200 mg twice a day for one week . If the patient struck toenails, treatment should be three-course . Irunine taken one week, followed by an interval of three weeks . If the patient struck fingernails, treatment should be two courses . Irunine taken one week, followed by an interval of three weeks . Patients with systemic aspergillosis take 200 mg in knocking over 2-5 months . If there is such a need, the dose can be increased to 200 mg twice a day . In the systemic candidiasis is necessary to take 100-200 mg of the drug once a day from three weeks to seven months . If there is such a need, the dose can be increased to 200 mg twice a day . Patients with systemic cryptococcosis without signs meningitis should take 200 mg once a day. As a maintenance therapy is used 200 mg once a day. Admission Irunine continues from 2 to 12 months. At cryptococcal meningitis the drug is carried out twice a day in 200 mg. When treating gistoplazmozapervonachalno taking 200 mg once a day, more dosing frequency increases to two times per day. Therapy lasts eight months. Sporotrichosis patients taking 100 mg once a day for three months. When treating paracoccidioidomycosis should take 100 mg once a day for six months at lecheniihromomikoza - 100-200 mg once a day for six months, in the treatment of blastomycosis - 100 mg once daily and 200 mg twice a day for six months.
Contraindications and possible side effects:
The drug should not be taken in patients with severe hypersensitivity to its components. Irunine not be received during pregnancy and breastfeeding. Caution should be given to patients with PM cirrhosis of the liver , Heart failure, chronic renal failure, as well as children and the elderly.
As the side effects in the digestive system are possible symptoms of dyspepsia, nausea, loss of appetite and abdominal pain, vomiting, diarrhea, constipation . Can increase the activity of "liver" transaminases, hepatitis occur, cholestatic jaundice. In the nervous system may be a manifestation of headache, dizziness, peripheral neuropathy. Also, when taking the drug may cause allergic reactions, skin rash and itching, hives, angioedema, erythema multiforme exudative. Among other side effects you may experience alopecia Manifestation dysmenorrhea . hypokalemia A high level of fatigue, edema syndrome.
Specific recommendations:
People with disorders of the immune system to achieve the effect may require a higher dose of the drug. If the patient takes Irunine longer than one month, it is necessary to monitor liver function. Women who are in childbearing age should use contraceptives during drug therapy. Irunine has the ability to enhance and make Bole long action means that the metabolism is mediated by enzymes such as Cytochrome P450 .
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