Sonapaks

Description overdue on 26/05/2014

• Latin name: Sonapax
• ATC code: N05AC02
• Active substance: Thioridazine (Thioridazine)
• Manufacturer: PHARMACEUTICAL WORKS JELFA, S.A, Poland

Photos of the drug

Tweet

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications sonapaks
• Contraindications
• Side effects
• Instructions for use sonapaks (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The active substance sonapaks, international name (INN), which - thioridazine,   It is thioridazine hydrochloride Which in one tablet contains 10 mg or 25 mg.

As auxiliary substances are: lactose monohydrate, talc, colloidal silicon dioxide, gelatin, corn starch, stearic acid.

The shell composition includes gum acacia, sucrose, talc, a colorant.

Product form

Coated tablets, round, have a light pink color, a break - white. The package of 20 tablets in a carton contains 3 packages.

Pharmacological action

Tablets Sonapaks have antipsychotic, antidepressant and tranquilizing effect.

Pharmacodynamics and pharmacokinetics

The active ingredient has a central and peripheral effects on the nervous system. The substance is able to inhibit certain functions of the brain stem, as well as provide antihistaminic   and hinolitichesky effect . Do not suppress the motor activity, antiemetic action has not, estrapiramidalnye violation   provokes less than other antipsychotics.

In addition, thioridazine has a weak antidepressant, and antipsychotic effects antiautichnoe.

Because the intestine is absorbed completely. It reaches maximum concentration after taking 2-4 hours. Kidneys derived about 35% of the formulation, the rest - through the intestines (as in the pure form or in the form of metabolites). Across blood-placenta barrier   thioridazine passes into breast milk.

Indications sonapaks

The drug is prescribed in the following diseases:

• schizophrenia ;
• psychomotor agitation;
• abstinence symptom ;
• psychoses ;
• Huntington's disease ;
• schizoaffective disorder;
• teak;
• psychosomatic disorders;
• aggressiveness, inability to concentrate for a long time;
• neuroses Which are accompanied by sleep disorder, anxiety, compulsions, mental and emotional stress, depressive disorders, fear;
• skin diseases, which are accompanied by severe itching.

For children, the indications for use sonapaks - behavioral disorders associated with increased psychomotor activity.

Contraindications

Do not take the drug in the following cases:

• children up to 4 years;
• hepatic failure ;
• pronounced CNS depression;
• lactase deficiency ;
• Hypersensitivity to any component of the drug and any derivative of phenothiazine;
• expressed depression ;
• Arrhythmia ;
• lactose intolerance or fructose;
• lengthening the interval QT, administration of drugs prolonging the interval QT;
• blood diseases;
• decreased activity of isozyme CYP2D6;
• galactose malabsorption glucose- ;
• coma .

Prescribe drugs with caution in the following cases: violation of hematopoiesis, Parkinson's disease . cachexia . alcoholism . angle-closure glaucoma . myxedema . vomiting . mammary cancer . renal failure . Reye's syndrome . duodenal ulcer   and stomach . prostatic hyperplasia . epilepsy , Diseases that increase the risk of thromboembolic complications, diseases that are accompanied by respiratory disorders. QT prolongation increases the risk of the strongest manifestations of the toxic effect.

Side effects

Medicine Sonapaks may cause the following side effects:

• agitation . insomnia , Violation of thermoregulation, fainting , Confusion, agitation, Parkinsonism , Reducing the seizure threshold, tardive dyskinesias, dystonic disorder , Emotional disturbance, the CSN, extrapyramidal disorder;
• cholestatic hepatitis . anorexia . diarrhea , Increased appetite, vomiting, sialoschesis , Nausea, hypertrophy of the lingual papillae, dyspepsia . ileus ;
• tachycardia   (including type " pirouette "), Reducing the pressure, ECG changes (including QT interval elongation, depending on the size of the dose);
• leukopenia . pancytopenia . thrombocytopenia . agranulocytosis . granulocytopenia . aplastic anemia . eosinophilia ;
• rash, allergic skin reactions, exfoliative dermatitis . erythema . bronhospastichesky syndrome , nasal congestion, angioedema ;
• photosensitivity, melasma   (develops at high doses for a long time);
• weight gain, a false positive pregnancy test;
• dysmenorrhea . paradoxical ischuria , Abnormal ejaculation, hyperprolactinemia . dysuria , Decreased libido, priapism . gynecomastia ;
• photophobia, blurred vision.

Instructions for use sonapaks (method and dosage)

The tablets are taken by mouth, the dosing regimen for each patient is determined individually.

Adults with psychosis   usually given in an outpatient setting 150-400 mg per day, divided into 3-4 receptions in hospital - 250-800 mg. Treatment should begin with low doses (25-70 mg per day), the dose size is gradually increased until the optimum effect (antipsychotic effect observed after treatment after 10-14 days). Treatment usually lasts for several weeks. As a maintenance dose of 70-200 mg administered once before bedtime. Elderly prescribe a lower dose - 100-300 mg. Cancelling the drug should be gradually.

The therapeutic dose of light emotional   and mental disorders   per day is 50-200 mg.

At psychosomatic disorders   the day should take 10-75 mg.

If you want to suppress severe itching dose size is set on an individual basis, but it should not be more than 200 mg.

Children between the ages of 4-7 years per day should take 10-20 mg (in two-three stages); 8-14 years - 20-30 mg (in three stages), 15-18 years - 30-50 mg (in three stages).

Instructions on when Sonapaks withdrawal syndrome : Patients administered from 10 to 400 mg depending on the condition.

Overdose

Drug overdose the following symptoms:

• ECG changes, ventricular fibrillation . Arrhythmia . ventricular tachycardia , Lengthening the intervals PR and QT, bradycardia , Sinus tachycardia, reduction of pressure suppression function of the myocardium;
• sedation, hypothermia . coma , Confusion, extrapyramidal disorder, hyperthermia . agitation . arefleksiya ;
• urinary retention, mydriasis , Dry skin, nasal congestion, corestenoma , Blurred vision;
• apnea, respiratory depression, pulmonary edema;
• constipation , Decreased gastrointestinal motility, intestinal obstruction;
• uremia . oliguria .

Toxicity occurs at concentrations thioridazine more than 10 mg / l in plasma death occurs at a concentration of 20-80 mg / l.

For treatment it is necessary to establish adequate pulmonary ventilation and oxygenation. It is necessary to conduct an ECG. The essence of the treatment for the correction of electrolyte abnormalities, you must enter Lidocaine While respecting caution, as there is the risk of seizures, isoproterenol . phenytoin . It should be used quinidine . procainamide and dizopiramid As they may affect the increase in the interval QT.

For suppression of acute disorders should use ektrapiramidalnyh trihexyphenidyl or diphenhydramine .

Cooperation

Admission sonapaks can enhance the action antihypertensive . analgesic . Narcotic   and hypnotics means As well as alcohol; enhance anticholinergic effect amitriptyline .

Sonapaks reduces the action amphetamine . levodopa .

The combination of the drug with ephedrine may cause hypotension. Antisteroidnye funds   in combination with the drug increases the risk of agranulocytosis .

QT prolongation may be caused by taking Probucol . cisapride . astemizole . pimozide . Erythromycin . quinidine and dizopiramida That can lead to Ventricular tachycardia .

Terms of sale

Leave from pharmacies only in the presence of a prescription from a doctor.

Storage conditions

Tablets should be stored in a dry place, the temperature should not be higher than 25 ° C.

Shelf life

4 years.

Cautions

If necessary, discontinuation of the drug, it should be done gradually.

As the drug reduces the rate of reaction and the coordination weakens, the patients in the period of treatment should not drive vehicles.

Analogs

Match code ATC 4th level:

• Neuleptil

Analogs sonapaks: Tioril . Rispolet . Seroquel .

Sonapaks and alcohol

During the reception sonapaks alcohol consumption is excluded, since the risk Hepatotoxicity reaction . Dystonia . heatstroke   and disorders of the nervous system .

During pregnancy and lactation

The drug is contraindicated in the last week of pregnancy and during the I trimester. The rest of the reception of the drug is possible if the risk to the mother more than the fetus. At the time of treatment of breast-feeding should be suspended.

Reviews sonapaks

On the forums, you can read reviews of patients taking the drug, who note that it is soft and weak antipsychotic that is well tolerated and rarely causes side effects. However, many believe that it is in men impotence .

Reviews doctors Sonapaks mostly positive, but some doctors consider that this drug has expired, also bad for the heart.

This medication is often prescribed for hyperactive and inattentive children reviews have both positive and negative. One he helped others write about the increased activity of the child, or, conversely, of the inhibition after receiving the drug. For children, this drug is harmless, it is very well tolerated.

Wikipedia data sonapaks not.

Price sonapaks where to buy

The cost of the drug in Ukraine is on average 116 UAH.

In Russia, the price sonapaks ranges from 290 rubles.

Get the best price and buy