Description overdue on 05/22/2014
- Latin name: Prestarium
- ATC code: C09AA04
- Active substance: Perindopril (INN)
- Manufacturer: The French company «Les Laboratoires Servier»
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Prestarium (spectrum use)
- Contraindications
- Side effects
- Instructions for use Prestarium (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Each tablet contains tretbutilaminovaya salt of perindopril and optional ingredients: magnesium stearate, hydrophobic silica, lactose monohydrate.
The composition of the drug BBC Prestarium further includes Amlodipine .
Prestarium Combi It contains indapamide .
Product form
The medicine is available in tablet form.
Dosages Prestarium : 2mg, 4mg and 8mg.
Dosages A Prestarium 2, 5 mg, 5 mg and 10 mg.
BBC Prestarium available in doses of 5 + 5 + 5 10 + 10 and 10 mg.
Pharmacological action
Antihypertensives . Active substance inhibits angiotensin-converting enzyme, which leads to a decrease in blood pressure by reducing vasoconstriction . Under the influence of the drug reduced production aldosterone , Renin activity is enhanced and increased decay bradykinin . The drug has no effect on pulse increases renal blood flow (glomerular filtration is not affected). The active component increases the elasticity of the large vessels, leads to a reduction in the size of the left ventricle increased.
AT BBC Prestarium amlodipine shows that blocks specific calcium channels. Active component expands the lumen of blood vessels, improve blood flow in coronary and peripheral vessels, reduces afterload on the myocardium . Amlodipine does not lead to metabolic disorders, it does not affect the lipid profile .
Pharmacodynamics and pharmacokinetics
The medicament reduces the total pressure in the capillaries of the lung tissue leads to the regression of enlarged left ventricle, restores the elasticity of the large vessels. Under the influence of the drug stabilized isoenzyme profile myosin , Normalizes cardiovascular system, reduced afterload, preload, decreased heart rate, decreased pressure in the lumen of the ventricles, increasing Regional blood flow muscle tissue. If you cancel a drug withdrawal syndrome does not develop.
The maximum concentration observed at 60 minutes after administration of the tablet. Metabolites are excreted primarily through renal system . Abstract to the drug provides an indication of the registration of stable therapeutic effect on day 4 of treatment.
Indications Prestarium (spectrum use)
From what tablets Prestarium :
- hypertonic disease ;
- cardiovascular failure.
Doctors prescribe perindopril not only as a tablet of the pressure, but also for the prevention of heart attack and stroke .
Indications for use of the drug A Prestarium :
- stable form of ischemic heart disease (to reduce the risk);
- prevention of stroke in patients with transient ischemic attack history (recommended combination with indapamide).
Contraindications
Medicine A Prestarium not prescribed for:
- intolerant of ACE inhibitors;
- gestation pregnancy ;
- angioedema ;
- breast-feeding ;
- galactosemia.
Use of drugs is limited when:
- reducing BCC ( hemodialysis , Salt-free diet, diarrhea syndrome, profuse vomiting, use of diuretic medications);
- at renovascular hypertension ;
- hyponatremia;
- immunosuppressive treatment;
- at aortic stenosis ;
- systemic connective tissue disease;
- at hyperkalemia ;
- after kidney transplantation.
Side effects of perindopril (Adverse reactions)
Digestive tract :
- change in taste perception;
- vomiting;
- nausea;
- dry mouth.
Nervous system :
- convulsions;
- sleep disorders;
- dizziness;
- migraine pain;
- depressed mood.
Blood System :
- thrombocytopenia;
- level decrease Hemoglobin ;
- reducing the number of erythrocyte .
Perhaps the development of dry cough Reversible reduction creatinine and indicators of uric acid, a violation potency , Redness of the skin, rashes, angioedema.
Instructions for use Prestarium (method and dosage)
Tablets are advised to take before meals.
Treatment of hypertension: average daily dose - 4 mg. If necessary, after one month the dose can be increased to 8 mg. A combination of a diuretic medication. Elderly patients over 70 years old who are taking diuretics, it is recommended to take 2 mg of perindopril in the morning. After 1 month the dose may be increased to 4 mg.
After repeated stroke Preventive therapy is prescribed to 2 mg for 2 weeks, and then added to the treatment regimen indapamide. Preventive maintenance can be carried out not earlier than 14 days after the stroke.
At pathology of renal the drug is dosed individually, based on the performance of creatinine in the blood.
At chronic cardiovascular disease starting dose is 2 mg once daily. With low blood pressure, heart failure grade 4 is recommended to take 1 mg per day.
Instructions BBC Prestarium 10/10 mg : It is unacceptable self-separation and size reduction pills. The drug is recommended to take before breakfast for maximum effect.
Instructions for use and 5.5 mg Prestarium : Tablets must be taken in the morning, without chewing.
Overdose
Fouls electrolyte balance . shock , Fall in blood pressure cough . anxiety . bradycardia . hyperventilation , Renal failure, dizziness.
Assist: drop in blood pressure when the patient is transferred to a position lying down, as far as possible compensate for BCC, intravenous catecholamines , Were infused angiotensin 2. In resistant bradycardia resort to pacemaker . Required round the clock monitoring of blood pressure, heart rate, ECG before stabilization. Good effect hemodialysis. Do not use polyacrylic membrane at vysokoprotochnyh Dialysis .
Cooperation
Procainamide Antipsychotic agents, narcotic analgesics, anti-diabetic medicines, lithium cytostatics . allopurinol , Systemic corticosteroids and immunosuppressants is not recommended to assign.
Absorbability of the drug is broken while taking spironolactone . amiloride . triaterena .
Terms of sale
OTC Product.
Storage conditions
Temperature range is not more than 30 degrees Celsius.
Shelf life
2 years
Cautions
Patients with hypertension Observant salt-free diet and take diuretics , You must notify the treating doctor. With the development of a dry cough is required to consult a doctor. Perhaps the development of allergies .
In the treatment of drug BBC Prestarium may appear swelling in the legs at the ankles (a side effect of amlodipine).
Analogs Prestarium (on the structural composition)
Monopril
Renitek
Charter
Fozikard
Amprilan
Ramipril
Perindopril
Perineva
Capoten
Berlipril
Akkupro
Diroton
Enap
Enalapril
The medication can be replaced (replacement structure): Perineva . Parnavel . Perindopril Richter . The analogue BBC Prestarium not developed. The product is original and expensive, so the price is much lower Prestarium counterparts.
During pregnancy and lactation
Contraindications.
Reviews Prestarium (general opinion)
Tablets are well tolerated without causing significant side effects. Reviews of patients with evidence of efficacy in the treatment of hypertensive disease .
Reviews A 5 mg Prestarium : Medical forums contain extremely positive feedback on the use of medicines. At low efficacy recommend another form of the drug - BBC Prestarium 10 mg .
Price Prestarium where to buy
Price A 5 mg Prestarium an average of 450 rubles. Buy drug can be in the pharmacy.
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