Description overdue on 03/28/2014
- Latin name: Sirdalud
- ATC code: M03BX02
- Active substance: Tizanidine hydrochloride
- Manufacturer: NOVARTIS Saglik Gida ve Tarim Urunlery Sanayi ve Ticaret, AS, Turkey
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications sirdalud
- Contraindications
- Side effects
- Instructions for use sirdalud (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
Depending on the form of, sirdalud 1 tablet contains 4 mg or 2 mg tizanidine . Also present in the composition of excipients:
- MCC ;
- lactose monohydrate ;
- stearic acid ;
- silicon dioxide, anhydrous colloidal .
Product form
The package contains 30 tablets and 2 mg of 4 in the blister pack contains 10 tablets and blister pack 3.
2 mg Tablets : White, flat, round, on one side of the line, on the other - the code «OZ».
4 mg tablets : White, flat, round, with one side of the inscription «RL», on the other - the intersecting line.
Pharmacological action
It is a centrally acting muscle relaxant.
Pharmacodynamics and pharmacokinetics
Tizanidine - skeletal muscle relaxant, the main place of action - the spinal cord. This drug decreases increased skeletal muscle tone . relieves spasms . It increases the power of arbitrary cuts . Sirdalud is effective in chronic spasticity Cerebral and spinal genesis and acute muscle spasm . In addition, it provides an easy and analgesic effect .
Tizanidine absorbed quite rapidly and virtually completely. The biggest indicator of the concentration of drug in plasma may occur approximately one hour after its adoption. The substance is excreted by the kidneys.
Indications sirdalud
From what Sirdalud tablets? Indications are as follows:
- muscle spasm That is associated with spinal cord injuries (these include lumbar and cervical syndrome ), Or which appeared after the intervention of the surgeon;
- skeletal muscle spasticity the manifestation neurological diseases ( disseminated sclerosis . Chronic myelopathy . cerebral palsy . degenerative diseases of the spinal cord ).
Contraindications
At present there are a number of known drug contraindications:
- idiosyncrasy component present in the formulation;
- significant liver dysfunction;
- children and adolescents under 18 years.
Special care must be taken to patients whose age more than 65 years And in patients with impaired renal function .
Side effects
Side effects sirdalud include:
- dizziness . drowsiness . sleep disorders . insomnia ;
- bradycardia . lowering blood pressure ;
- stomach upset . nausea . dry mouth ;
- fatigue . muscular weakness ;
- Increased activity hepatic transaminases .
As a result, abrupt cessation sirdalud decision after a long period of treatment may develop tachycardia Pressure increase, which may lead to poor circulation of the brain, so that the dose should be reduced gradually, until its complete cancellation.
As a result, clinical trials showed the following adverse events, the frequency of symptoms that are not detected:
- confusion . hallucinations . vertigo ;
- blurred vision ;
- hepatic failure . hepatitis ;
- withdrawal . asthenia .
Instructions for use sirdalud (method and dosage)
The drug is ingested orally, the dosage is determined based on the individual characteristics of the human body. To minimize the risk of side effects should start with a dose - one tablet (2 mg) or poltabletki (4 mg) three times a day.
At severe muscle spasm Tablet 2 mg or 4 mg administered three times per day. In severe cases, it can be taken further bedtime dose of 2 mg or 4 mg.
When the manifestation skeletal muscle spasticity Which may be caused by neurological disease, the initial dose - 6 mg per day taken in 3 doses. You must gradually increase the dose, 2-4 mg, the interval of 3 to 7 days. Optimal effect is achieved when receiving 12-24 mg per day, 3-4 times a day. Do not take a dose higher than 36 mg per day.
Persons older than 65 years recommend to start taking the drug with the lowest dose, increasing it step by step to the optimal size, which would achieve effective therapy and minimal side effects.
Patients with impaired renal function you need to start treatment with a dose of 2 mg per day in one step. The dose is increased gradually, in small steps, given the efficacy and tolerability of the drug.
Instructions for use of the preparation Sirdalud MR
The preparation is a capsule containing 6 mg of tizanidine. Sirdalud initial dose is 1 capsule per day. Gradually increasing the dose may be 6 mg every 3 to 7 days. For most patients the optimal dose of 12 mg per day. In rare cases, the dose can be increased to 24 mg (4 capsules) per day.
Injections of the drug can only appoint a doctor.
Overdose
Sirdalud Tinazidin drug overdose can be expressed as follows:
- lowering blood pressure ;
- vomiting . nausea ;
- drowsiness . dizziness . anxiety . corestenoma ;
- coma . respiratory failure .
Treatment: multiple adoption Activated Carbon and forced diuresis accelerate the elimination of the drug from the body. After the removal is carried out symptomatic treatment .
Cooperation
The simultaneous consumption of drugs with CYP1A2 inhibitors of cytochrome It leads to higher levels of tizanidine in plasma, which in turn leads to symptoms of an overdose. Simultaneous intake with sirdalud inducers of CYP1A2 It lowers the level of tizanidine that causes a decrease in the therapeutic properties of the drug.
Do not use this with sirdalud fluvoxamine . ciprofloxacin . The result of the simultaneous application can be a significant reduction in blood pressure, which is accompanied by dizziness and drowsiness, and in some cases - loss of consciousness.
Not recommended to take the medicine antiarrhythmic drugs (such as propafenone . mexiletine . amiodarone ), Some fluoroquinolones ( norfloxacin . enoxacin . perfloksatsin ) cimetidine . ticlopidine . oral contraceptives . rofecoxib .
Precautions must be taken Sirdalud with those drugs that prolong the interval QT ( amitriptyline . cisapride . azithromycin and etc.).
Application Sirdalurda with rifampicin tizanidine reduces the content in the plasma and thus reduces the therapeutic effect of the drug.
Treatment with male smokers may require increased doses. Avoid drinking alcohol as a drug can amplify the negative impact of alcohol on the central nervous system. Sedation sirdalud can enhance hypnotics, sedatives and antihistamines.
Terms of sale
Prescription medications.
Storage conditions
Store at temperatures not exceeding 25 ° C, out of reach of children.
Shelf life
Shelf life is 3 years.
Cautions
The drug is not recommended for patients who have galactose intolerance As well as suffering from severe failure Lactase or glucose / galactose malabsorption , Due to the presence of lactose in the composition.
Since one of the side effects of the drug is drowsiness , It is recommended to refrain from driving or performing work related to the mechanisms or machines.
Analogs sirdalud
Tizalud
Baklosan
Baclofen
The analogue of Sirdalud the shape and composition of the release is Tizalud . Also, the composition is an analogue Mydocalm which is available as a film-coated tablets, as well as a solution for injection.
Price analogues sirdalud: Tizalud costs from 55 to 72 UAH .; Mydocalm depending on the form of the issue - from 67 to 98 UAH.
Mydocalm or Sirdalud: which is better?
Sirdalud is more of a modern preparation having a formulation which allows to take it once a day, while more Mydocalm examined by doctors, has broader indications. The side effects of both drugs are similar.
Reviews for Sirdalud
Reviews tablets Sirdalurd leave patients of different ages. The average score on the forums for the drug is 3, 9 points out of 5. Many patients notice the occurrence of side effects such as drowsiness and fatigue. Also, there are reports on the impact of drugs on the liver.
Doctors about Sirdalud: the drug is used for symptomatic treatment, it reduces muscle spasms of the skeleton. If a strong manifestation of side effects or lack of results at 3 days of medication, you should consult your doctor in order to adjust therapies.
Price Sirdalud
The price of the tablets 2 mg in the average is 80 UAH., The price is 4 mg - 120 UAH.
The cost of such tablets in Russia is 220 rubles, respectively. and 360 rubles.
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