Description overdue on 07/14/2014
- Latin name: Diphereline
- ATC code: L02AE04
- Active substance: Triptorelin (Triptorelin)
- Manufacturer: Ipsen Pharma, France
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Diferelin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- With alcohol
- Reviews
- Price, where to buy
Composition
One vial contains triptorelin acetate . As an auxiliary substance acts mannitol . The solvent composition includes sodium chloride and water.
- Valium for manufacturing solution for subcutaneous administration - 1 vial. Triptorelin (triptorelin acetate) - 0 1 mg . Mannitol - 10 mg. 1 ampoule of solvent - water for injection, sodium chloride.
- Valium for suspension / m administration The long-acting - 1 fl. Triptorelin (triptorelin acetate) - 3 75 mg . Auxiliary substances: carmellose sodium, a copolymer of glycolic and DL-lactic acids, polysorbate 80, mannitol . 1 ampoule of solvent - water for injection, mannitol. Given the characteristics of the dosage form, the active ingredient in the formulation is contained in excess. Objective - ensuring optimal dose administration.
- Valium for cooking suspension / m administration The long-acting - 1 fl. Triptorelin (triptorelin acetate) - 11 25 mg . Auxiliary substances: carmellose sodium, a copolymer of glycolic and DL-lactic acids, polysorbate 80, mannitol. 1 ampoule of solvent - water for injection, mannitol. Given the characteristics of the dosage form, the active ingredient in the formulation is contained in excess. Objective - ensuring optimal dose administration.
Product form
Diferelin - 0 1 mg
Available in bottles. The kit includes vials with solvent. The Valium planimetric package contains 7 sets. The cardboard package is a package. We introduce n / a.
Diferelin - 3 75 mg
Available in bottles. The kit includes vials with solvent syringe, two needles. The carton box is one set. Introduced into / m.
Diferelin - 11, 25 mg
Available in bottles. The kit includes vials with solvent syringe, two needles. The carton box is one set. Introduced into / m.
Pharmacological action
Hormonal drug, which is an analogue gonadotropin-releasing hormone.
Pharmacodynamics and pharmacokinetics
It is synthetic decapeptide , An analogue of natural gonadotropin-releasing hormone Which releases gonadotrophin . The drug is rapidly absorbed after administration. In intramuscular a rapidly released active ingredient.
Indications
Diferelin 0 1 mg
When the women infertility . Held in parallel with the ovarian stimulation gonadotropins . In IVF, and during other reproductive programs.
Diferelin 3 75 mg
- Cancer of the prostate cancer;
- with early puberty;
- at genital endometriosis and Extragenital ;
- at uterine fibroids during the pre-operational intervention;
- if female infertility (IVF program).
Diferelin 11, 25 mg
- Cancer of the prostate cancer (metastases);
- genital and extragenital endometriosis.
Contraindications
General: pregnancy , Lactation, hypersensitivity .
Diferelin 11, 25 mg (optional)
- Cancer of the prostate gland hormone-;
- beyond surgical tekstikul ectopia .
Used carefully at polycystic ovary syndrome .
Diferelin 11, 25 mg, 3 mg 75 (optional)
Used carefully at osteoporosis .
Side effects
Common for all dosages of the drug
When treating female infertility at the beginning of the drug in parallel with gonadotropins It can be caused by ovarian hyperstimulation: enlargement of the ovaries, abdominal pain.
During treatment occur: decreased libido, vaginal dryness . dyspareunia Unexpected tides.
Long-term use can cause bone demineralization and increase the risk of osteoporosis (after brief use Diferelin 0, 1 mg of these symptoms were not observed).
Allergic reaction: rash . hives , Itching, in rare cases - angioedema .
Rare: increase in blood pressure, nausea, vomiting, and emotional lability, weight gain, blurred vision, pain in the administration.
Very rare: pain in joints and muscles, headache.
Additionally, Diferelin 3, 75 mg
Men: reduced potency . At the beginning of the drug in patients with cancer of the prostate gland can cause sharp pain in the bones affected by metastases. In some cases, there is ureteral obstruction or symptoms associated with compression of the spinal cord metastases (disappear for one - two weeks).
The drug for the treatment of early puberty in girls can provoke vaginal blood discharge .
If long-term treatment may cause hypogonadotropic amenorrhea .
After the treatment there is a restoration of ovarian function. Ovulation It occurs about the 58th day of the last injection. Menarche - 70 minutes a day. It is important for planning contraception.
Further, Diferelin 11, 25 mg
Men: the beginning of the reception possible dizuricheskie violation Pain in the bones. Symptoms are within one - two weeks.
During treatment: decreased libido, impotence . gynecomastia To face flushing.
Women: At the beginning of the drug possible dysmenorrhea , Pelvic pain. Disappear within one - two weeks.
You may experience metrorragii a month from the start of injection.
Men and women: fatigue, depression , Mood disorders, irritability, sleep disturbances, fever , Blurred vision, paresthesia , Profuse sweating, increased body mass index.
Instructions on Diferelin (method and dosage)
Instructions on Diferelin 0 1 mg It includes short and long protocol. The drug is injected s / c.
Short protocol : The drug begins with the second day of the cycle. This involves simultaneous stimulation of the ovaries. Treatment ends the day before the administration gonadotropin . The total course of treatment 10-12 days.
Long protocol Diferelin The drug is administered on the second day of the cycle. Administered daily. Around the 15th day of the drug carried out in parallel stimulation of gonadotropins. The duration of treatment is individual and adjusted by your doctor.
Preparation of the solution Before the introduction of the drug is introduced into the solvent vial with lyophilisate. Completely dissolve.
Diferelin 3 75. / m . When the disease prostate cancer - Is introduced into the respective dose - 3, 75 mg for a long time every 4 weeks. With adrenarche - 3, 75 mg administered every 28 days. When the disease endometriosis Diferelin depot medication is administered in the first five days of the cycle each month. With female infertility drug is administered on the second day of the cycle.
Diferelin 11, 25 administered in a volume of 11 to 25 mg every three months.
Preparation of the solution : Immediately before administration the solvent is injected into the vial with lyophilized. Completely dissolve gently shaking the contents of the vial.
Overdose
To date, information about overdose has been reported.
Cooperation
Cases interactions are not described.
Terms of sale
Prescription.
Storage conditions
At a temperature of 25 ° C out of reach of children.
Shelf life
2 years.
Diferelin and alcohol
Upon receipt of any drug is not desirable to use alcohol . When combining may reduce the effect of the treatment. If we are talking about female infertility , In which case combining the drug with alcohol is prohibited.
Reviews Diferelin
Reviews Diferelin are usually positive. If you use the drug for its intended purpose and according to the instructions the effect will be made, so read the reviews gynecologists. At the forum you can read a variety of comments about the drug. But it is worth remembering that the drug is not suitable for all people. Each different organisms and thus different reaction. Therefore, this issue is best to consult with a specialist, and to choose the right dose and the period of treatment. Then the reviews are extremely positive.
Price Diferelin where to buy
Price Diferelin in Russia ranges from 2,000 to 20,000 rubles, depending on volume. Buy drug can be in virtually every pharmacy city. In Ukraine, from 2000 to 5000 UAH.
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