doctor: AnviMaks

Description overdue on 07/08/2014

Latin name: AnviMaks
ATC code: R05X
Active substance: Paracetamol, ascorbic acid, calcium gluconate, Rimantadine, Rutoside, loratadine
Manufacturer: JSC "Farmproekt" NPO "PharmVILAR", JSC "PharmFirma" Sotex "(Russia)

Photos of the drug

Composition
Product form
Pharmacological action
Pharmacodynamics and pharmacokinetics
Indications
Contraindications
Side effects
Instructions for use AnviMaksa (method and dosage)
Overdose
Cooperation
Terms of sale
Storage conditions
Shelf life
Cautions
Analogs
AnviMaks children
During pregnancy (and lactation)
Reviews
Price, where to buy

AnviMaks

Composition AnviMaksa

The oral powder (the dosage of active compound calculated to one packet for a single use) consists of components such as:

paracetamol - 360 mg;
ascorbic acid - 300 mg;
calcium gluconate monohydrate - 100 mg;
hydrochloride rimantadine - 50 mg;
trihydrate Rutoside - 20 mg;
Loratadine - 3 mg.

As auxiliary substances which allow the main components to provide better pharmaceutical effect are used:

lactose monohydrate - 4, 086 g;
Aspartame - 30 mg;
colloidal silica - 20 mg;
Hypromellose - 10 mg;
a flavor with taste of lemon, honey, black currant or raspberry - 21 mg.

Active ingredients Capsules P :

Paracetamol - 360 mg;
pregelatinized starch - 9 mg;
Colloidal silica - 3 mg;
monohydrate lactose - 4, 2 mg;
magnesium stearate - 3, 8 mg.

Directly capsule type II in its composition is:

gelatin - 94, 795 mg;
titanium dioxide (E171) - 1, 94 mg;
blue a patented dye is (E131) - 0, 265 mg.

The composition of the AnviMaksa in P capsule :

ascorbic acid - 300 mg;
calcium gluconate monohydrate - 100 mg;
rimantadine hydrochloride - 50mg;
Rutoside trihydrate in terms of pure Rutoside - 20 mg;
magnesium stearate - 4, 8 mg;
Loratadine - 3 mg;
potato starch - 2, 2 mg.

The capsule type F consists of the following components:

gelatin - 94, 064 mg;
iron oxide yellow dye (E172) - 0, 97 mg;
carmine dye (Ponce 4R) (E124) - 0, 511 mg;
iron oxide red dye (E172) - 0, 485 mg;
titanium dioxide (E171) - 0, 97 mg.

Product form

The pharmaceutical preparation can be found on pharmacy shelves in the following way:

Powder Used for solution preparation and oral administration. Available with different flavors such as lemon, lemon, honey, black currant, raspberry. Medicinal powder is put into a heat resistant package, 3, 6, 12 or 24 pieces in the carton box.
Capsules for oral use , 10 pieces in the blister. In a cardboard bundle is placed 2 of contour of the plate. Capsules can be of two types: labeled P - A solid, gelatinous, blue, whose content is the mixture of granules and powder of white color, sometimes with a pink tinge or cream; P-capsules - Solid, gelatinous, red, inside which is placed a mixture of pellets and powder yellow-green or milky white.

Pharmacological action

The drug possesses a wide spectrum pharmaceutical effects occur:

antipyretic;
analgesic (pain);
an antihistamine;
antiviral;
interferonogenic;
angioprotective.

AnviMaks is combined preparation As it contains in its composition more biologically active components. Thus according to the drug therapy is complex, even when included in a conservative scheme readjustment only one position, and therefore should pay attention to the mechanism of action of each part separately.

Ascorbic acid (a chemical analog of natural vitamin C) - regulates the normal course of redox reactions, thereby helps to normalize the permeability of the capillary vascular bed . Stimulating effect on the immune system, it activates the natural regeneration of tissues. Acid also supports the normal functioning of plasma coagulation and platelet coagulation.

Calcium gluconate It acts as the donor ions which are embedded in the wall of blood vessels. This prevents the development of increased permeability and fragility of capillary vessels. In this way liquidated hemorrhagic link inflammation of the flu or a respiratory viral infection.

Rimantadine - A substance with high level specificity of action of a pharmaceutical, antiviral activity is directed solely to the virus Influenza A . Due to its chemical properties are blocked M2 feeds virus that impairs the ability of ribonucleoproteins for release and further penetration into the cell of a living organism. Thanks to these abilities pharmaceutical rimantadine hampered the main way viruses play, which favorably affects the state of the macro organism. Also biologically active component induces aimed elaboration alpha and gamma interferon , Thus stimulating humoral immunity.

Loratadine - Typical histamine receptor type H1 . How to composite component AnviMaksa, he warns the development of edema the nearby to the amazed malicious microflora of tissues, since prevents the generalizovannyj the release of histamine (biologically active amine, providing the main manifestations of of the inflammatory process - a tumescence, redness, hyperthermia and so hereinafter).

Rutoside - Pharmaceutical angioprotector , Ie the action given substance in primarily directed at the preservation integrity vascular wall. To fulfill its tasks integral component of the powder reduces the fragility and permeability of capillaries, inhibits the aggregation of red blood cells, increases the degree of deformation during the passage of the microvasculature. Also, he removes puffiness and inflammation in local portion that additionally strengthens the vascular wall pass.

Pharmacodynamics and pharmacokinetics

As with the pharmacological effect, the ability to grasp the pharmacokinetic AnviMaksa be traced pathways of each of the components of the combined preparation.

Paracetamol well absorbed from the gastrointestinal tract, the maximum plasma concentration It reached half an hour after administration at 4, 8 mg / ml. The substance is able to penetrate the blood-brain barrier and affect cerebral structures. Metabolized integral component AnviMaksa in the liver, konyugiruya with sulphates, glucuronides or oxidized by microsomal enzymes. Toxic intermediates sharing is only formed if paracetamol is held on the third chemical transformation path with mandatory participation glutathione , Cysteine mercapturic acid . With insufficient amount of cytochrome P450 metabolites may have a damaging effect on hepatocytes That leads to necrosis of liver cells. FUME exchange kidneys, the half-life is equal to 2, 8 hours, but at the individual features and can reach 3, 5 hours. In old age, clearance of the active substance is somewhat reduced, which manifests an increase in half-life.

Absorbent ascorbic acid predominantly in the jejunum. Its absorption may be inhibited gastrointestinal disease, eating fresh fruit or vegetable juices, copious amounts of alkaline beverages. The maximum plasma concentration It is reached after 4 hours after dosing and approximately 10-20 ug / ml. 25 percent of the acid binds to plasma proteins , The remainder can easily penetrate into red blood cells, particularly in leukocytes and platelets. Chemical deposited in the glandular organs, the liver and the lens of the eye. Ascorbic acid can penetrate through placenta and affect the fetus.

The active component is metabolized in the liver, kidneys, and through the intestines. Some of the acid can be allocated to the then unchanged. Sharply accelerated destruction "askorbinki" as a result of smoking and excessive use of ethanol, which leads to a decrease in the physiological reserves of the organism.

Calcium gluconate As ascorbic acid, advantageously absorbed through the jejunum. The adsorption capacity depends on the acidity of the contents of the gastrointestinal tract, the presence of ergocalciferol . Strongly urges on the possibility of calcium absorbed their deficiency in the blood plasma. Displayed active component on 80 percent an intestine and on 20 percent kidneys.

Rimantadine slowly absorbed in the digestive tract, it the maximum plasma concentration It achieved only 5-7 hours after administration of the pharmaceutical preparation. About 40 percent of the dose after one-time suction is capable of binding to plasma proteins, which ensures a constant concentration in the range of 50-80 ng / ml in the blood. It is metabolized in the liver, after which more than 90 percent metabolites excreted by the kidneys during the following 72 hours. The half-life is 20 to 45 hours. In old age, reduced renal clearance of creatinine, which contributes to the accumulation of rimantadine toxic concentrations Because the scheme of conservative treatment in this age group should be strictly controlled based on individual metabolic parameters.

Exchange Rutoside largely depends on the state of the gastro-intestinal tract and generally microorganism. Time to reach it maximum plasma concentration can range from 1 to 9 hours, half life - From 10 to 25 hours. Provided Rutoside metabolites in the bile and to a lesser extent the kidneys.

Loratadine Ascorbic acid is similar to their metabolic capacity. It quickly and adequately absorbed from the intestine, ensures that its accumulation in plasma already after 2-4 hours after drug administration. The maximum concentration of about 1-3 ng / ml, which provided 97 percent of the dose is one-time fee for connection to plasma proteins. Loratadine is not able to penetrate the blood-brain barrier, and therefore the side effects of central origin after receiving not wait.

Metabolised active component in the liver under the action isoenzymes system cytochrome . Excreted in the bile and kidneys. The half-life is 5-15 hours, depending on the individual. In patients with chronic renal insufficiency or type during hemodialysis pharmacokinetics of loratadine is not significantly changed. Older people taking AnviMaks, the maximum plasma concentration increases by approximately 50 percent.

Indications

AnviMaks is essential pharmaceuticals, which carries etiotropic treatment of influenza type A, that is due to the drug performed conservative therapy aimed at eliminating the causal factors of the nosological units.

In as a symptomatic treatment AnviMaks can be used in following clinical situations:

catarrhal diseases ;
acute respiratory viral infections;
pathological conditions, during which accompanied fever, muscle pain and headache , Chills.

Contraindications

hypersensitivity . idiosyncrasy Acquired or hereditary intolerance integral components of a pharmaceutical preparation;
pathology of the gastrointestinal tract (especially in acute stage);
bleeding diathesis ;
lack of fat-soluble Vitamin K ;
hemophilia ;
portal hypertension I ;
thyroid disease;
insufficient number of platelet;
leaking badly liver and kidney disease (glomerulonephritis, pyelonephritis, nefrourolitiaz , Kidney failure, hepatitis) or chronic diseases in the acute stage;
expressed hypercalcemia and hypercalciuria ;
alcoholism;
of sarcoidosis;
phenylketonuria;
during pregnancy and lactation (breastfeeding);
lactose intolerance , Inadequate absorption of glucose and galactose.

There are a number of diseases, when the absolute indications for use of the pharmaceutical preparation it should be included in the scheme of conservative therapy, but to carry out reception of the drug must be under the supervision of qualified medical personnel (it is recommended to undergo treatment in a day hospital). These pathologies include:

epilepsy;
cerebral atherosclerosis;
diabetes;
sideroblastic anemia;
increased amount of oxalate in the blood plasma;
lack of glucose-6-phosphate dehydrogenase ;
malabsorption;
dehydration and exsicosis;
thalassemia ;
of electrolyte composition of blood;
old age (especially in pathologies of the cardiovascular system involving hypertension ).

Side effects

Conservative treatment AnviMaksom can cause such undesirable consequences:

On the side CNS : Drowsiness or irritability, tremors, excessive mobility ( hyperkinesia ), Dizziness and headache, Arterial hyperemia facial skin.
On the side gastrointestinal tract : Dyspepsia, defeat the duodenal mucosa and stomach, dry mouth, flatulence (gas intraintestinal bloating), diarrhea, decreased appetite.
As part of the of hematopoiesis : Changes in blood parameters (need regular diagnostic tests during medical treatment).
On the side other organ systems - Development of depression insulin B-cells of the pancreas glyukozemiya . glycosuria and expressed manifestation of diabetes , Consequently. Also, an integrated drug can cause allergic reactions that manifest themselves in the form of itching, pigmented rash, urticaria.

Instructions for use AnviMaksa (method and dosage)

Used drug, regardless of the form of a pharmaceutical preparation, orally That is for oral administration.

Unless AnviMaks powder It is necessary to prepare a solution, adding the contents of the package half cup (about 100 ml) boiling hot water, stir the contents. Immediately to use inside. The daily dosage - 1 sachet 2-3 times per day. AnviMaks recommended to take after a meal, as the adsorption capacity of the gastrointestinal tract is stimulated by the passage of the bolus. The course of treatment is generally about 5 days. It is strictly forbidden to extend their own treatment.

Instructions on AnviMaks capsules prescribes to take on 1 piece 2-3 times a within days. As a powder, it is necessary to use the drug after meals, plenty of drinking water capsule. The therapeutic course of 5 days. If you feel better not come, should stop treatment and contact your doctor or a qualified pharmacist. In no case can not be arbitrarily extend the conservative reorganization.

Overdose

During the first days after administration of increased doses can be observed such AnviMaksa Symptoms of overdose :

paleness skin;
dyspeptic syndrome (nausea, vomiting, epigastric pain);
arrhythmia type tachycardia;
metabolic acidosis;
exacerbation of of concomitant of chronic diseases.

In severe overdose symptoms may appear within 48 hours after taking the drug and burdened hepatic insufficiency with encephalopathy and even the coma (due to accumulation of products of the metabolic exchange). In the absence of liver disease may develop renal failure from tubular necrosis apparatus .

Causal treatment of high concentrations of active ingredients of the drug administration acts donor of sulfhydryl groups and precursors of glutathione synthesis (means comprising methionine and acetyl cysteine ) During the first eight hours. As symptomatic of readjustment can be used gastric lavage or medikamentozno cause vomiting. The need for additional therapeutic interventions determined by the attending physician.

Cooperation

Paracetamol - An extremely active component of the drug component AnviMaks because the list is not very positive and the interactions of the biological product covers such a wide range of medicines. First of all, affect the metabolism of paracetamol Inductors of microsomal oxidation in hepatic, ethanol and hepatotoxic drugs . They greatly increase the production of hydroxylated metabolites that with insufficient rate of excretion can cause the development of severe intoxication even at low daily dosage. Inhibitors of microsomal oxidation are strictly opposite, reducing the risk of damage to the liver cells and allowing the active ingredient to circulate in the bloodstream longer.

Concomitant use of paracetamol and anticoagulants in the treatment, which is often found in severe respiratory diseases, improves the efficiency of the latter, and therefore requires a smaller dosage of drugs that affect blood clotting.

Prolonged treatment barbiturates may reduce the effectiveness of paracetamol. Concomitant use with Metoclopramide increases its rate of absorption.

Ascorbic acid It is not less active than Paracetamol. Its chemical exposure can accelerate the metabolic pathways iron supplementation . Thus by lowering the valence of from three to two improving their absorption in the gastrointestinal tract, and the simultaneous application of Deferoxamine increases the rate of excretion of drugs based on Ferrum.

When treating from alitsilatami and sulfanilamidnymi drugs increases the risk of crystalluria as accelerating the excretion of drugs and metabolites naturally alkaline. Including more active and displayed Alkaloids , Both vegetable and animal origin.

In the textbooks of Pharmacy described a very complex interaction ascorbic acid and ethanol . and Primidone .

ascorbic acid and .

K Cimetidine