Editsin

Description overdue on 15.02.2013

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The antibiotic, glycopeptide. The active component is vancomycin . The drug has a bacteriostatic effects against Enterococci   and bactericidal effect on other microorganisms. The main component of the antibiotic produced by Amycolatopsis orientalis. The mechanism of the main effects is aimed at blocking the process of synthesizing the bacterial cell wall, which ultimately leads to cell lysis. The active substance can affect the permeability of the cell membranes of bacteria that selectively inhibit the synthesis of RNA. Editsin affects korinobakterii, staphylococci , Enterococci, actinomycetes, clostridia. The drug acts on strains which are resistant to penicillin.

Optimum efficiency is observed at a pH of 8; a sharp decrease in the efficiency of the medicament is observed by lowering the pH to 6. The medicament is actively influenced only those microorganisms which are under reproduction. Mycobacteria, gram-negative flora, protozoa, viruses and fungi resistant to the action of the drug. Cross-resistance with other antibacterial drugs is observed. Editsin comes in the form of freeze-dried product from which the prepared solution for infusion.

Indications:

Drug Usage Editsin recommends prescribers with pneumonia, sepsis , Meningitis, endocarditis, lung abscess, pseudomembranous colitis , Skin infections, enterocolitis, osteomyelitis and other infectious lesions of the joints and bones.

Contraindications:

Editsin not apply when breastfeeding, neuritis of the auditory nerve, pregnancy, intolerance of the active ingredient of the drug. In the pathology of the renal system, violations of the auditory perception of the medication prescribed after consulting experts with caution.

Side effect:

Urinary system:   level increase BUN   and creatinine, nephrotoxicity   (development of renal failure) with concurrent therapy with aminoglycosides, rarely develops interstitial nephritis. The digestive tract:   pseudomembranous colitis, nausea. Senses:   vertigo , Violations of auditory perception, ototoxicity, tinnitus. Bodies of blood:   rarely develops agranulocytosis , Transient thrombocytopenia, reversible neutropenia. If you violate the rules and regulations infusion develop local reactions such as soreness of the injection site, phlebitis , Tissue necrosis at the infusion site. Rarely develop allergic reactions: fever, nausea, febrile syndrome, exfoliative dermatitis, rash, eosinophilia, vasculitis , Toxic epidermal necrolysis, erythema exudative malignant. With the rapid introduction developing postinfuzionnye reaction syndrome " red man "Caused by the release of histamine   (spasm of the muscles of the back and chest, flushing of the skin of the face and the skin of the upper half of the body, fever, chills, rapid heartbeat), anaphylactoid reactions (pruritus, dyspnea, bronchospasm , Drop in blood pressure, skin rashes).

Overdose:

Manifested increased expression of the above adverse reactions. Treatment is carried out in conjunction with posindromnoe hemofiltration   and hemoperfusion .

Mode of application:

Editsin injected only intravenously , The infusion rate does not exceed 10 mg per minute infusion duration not greater than 1 hour. Intramuscular injections are extremely painful. Adults appoint 7, 5 mg / kg every 6 hours or 15 mg / kg every 12 hours. Patients with abnormal renal excretory function of the drug administered in an initial dose of 15 mg / kg, further tactics of therapy with vancomycin determined index QC (when registering uremia injections are carried out at an interval of 10 days). Before the introduction of the powder solution was dissolved in water for injection: 1 g in 20 ml (solution concentration 5 mg / ml). The mixed solution is recommended to dilute the solution with 5% dextrose or sodium chloride 0% 9: 500 mg - 100 ml. Treatment of pseudomembranous colitis:   Editsin taken orally as a solution: 0, 5-2 gram diluted in 30 ml of water, taken 3-4 times per day. The course of antibiotic therapy is 7-10 days.

Special instructions:

Editsin prescribed during pregnancy, in exceptional cases and only for "vital" indications. The frequency of adverse events increased with concurrent therapy general anesthetics . Vancomycin must be administered prior to general anesthesia. When treating premature and normal newborns requires regular control indicator of the level of active substance in the serum. Throughout the course of therapy required control of the functional state of the renal system (level of urea nitrogen, creatinine, urine analysis), research audiogram . Patients over 60 years of age and renal failure is desirable to determine the level of active substance in the serum. It is unacceptable excess of the maximum score - 40mkg / ml. At concentrations above 80 .mu.g / ml toxic effects develop.

Drug Interactions:

In adults, there are violations intracardiac conduction In children appear erythematous rash concurrent therapy with local anesthetics. It is unacceptable simultaneous treatment of ototoxic and nephrotoxic drugs (bacitracin, salicylates, acetylsalicylic acid Amphotericin B, aminoglycosides, bumetanide, cyclosporine, paromomycin, carmustine, capreomycin, ethacrynic acid, cisplatin, polymyxin B, "loop" diuretics). When treating   kolestiraminom   a decrease in the efficiency editsinom. Phenothiazines, meklozin, antihistamine medication, thioxanthenes can mask the symptomatic manifestations ototoxicity   drug Editsin (vertigo, tinnitus). In the treatment of vecuronium bromide and application of general anesthetics may develop neuromuscular blockade, lower blood pressure. The introduction of vancomycin may not be earlier than 1 hour after the use of vecuronium bromide and general anesthetics.