Amoxiclav

Description overdue on 09.06.2012

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Combination antibiotic . The active components are Amoxicillin   and beta-lactamase inhibitor - Clavulanic acid . Amoxiclav bactericidal effect, is active against gram-positive flora, staphylococci, streptococci, leaves, anaerobic bacteria korinobaktery, enterococci, Proteus, klebsiel, Salmonella, Yersinia, Neisser. Clavulanic acid inhibits the activity of 2, 3, 4, 5 type of beta-lactamase; It has vyskokoy tropic to penicillinase that allows the formation of stable complexes with enzymes which prevents the degradation of the enzyme antibiotic amoksifillina exposed to beta-lactamase. Amoksiklav available in tablet form, as a powder, lyophilizate.

Indications:

Amoksiklav used for various bacterial infections. Airways: lung abscess , Empyema, pneumonia, bronchitis. ENT organs: otitis media . sinusitis . sore throat . Bile duct: cholecystitis, cholangitis. Digestive system: salmonellonositelstvo, salmonellosis . dysentery . Urogenital: salpingitis, cervicitis , Pyelonephritis, septic abortion, gonorrhea, chancroid, pelvioperitonit, puerperal sepsis, endometritis . tubo-ovarian abscess . urethritis , Cystitis, pyelitis. Skin, soft tissues: impetigo, erysipelas, cellulitis, abscesses, infected dermatitis, wound infections. The drug is prescribed for sepsis, meningitis, osteomyelitis, peritonitis, for the prevention of infectious lesions after surgery.

Contraindications:

Amoxiclav does not apply in case of intolerance of beta-lactam antibiotics, cephalosporins, if infectious mononucleosis , Morbilliform rash. When renal pathology of an antibiotic is prescribed, after consulting a nephrologist. Amoxiclav pregnancy used with caution.

Side effect:

Allergic reactions: exudative erythema , Erythematous rash, urticaria, exfoliative dermatitis. Digestive system:   rarely observed   pseudomembranous colitis , Hepatitis, cholestatic jaundice, increased liver enzymes, diarrhea, nausea and vomiting. The site of administration of the antibiotic may develop   phlebitis . Rarely observed development superinfection , Candidiasis, increased prothrombin time.

Overdose:

Characterized violation water and electrolyte balance , Disturbances in the digestive system. Recommended emergency hemodialysis, posindromnoe treatment.

Mode of application:

Amoxiclav taken orally. In severe infections administered at 500 mg three times a day by 1 gram or 2 times per day. In the preparation of syrups, suspensions, drops of water is used instead of a solvent. The maximum daily dose of the antibiotic by intravenous administration of 6 grams. The duration of antimicrobial therapy - up to 14 days. Prevention of postoperative complications: intravenously during induction of anesthesia is administered 1, 2 grams amoksiklava. Dosing of the drug during pregnancy Amoxiclav made individually. Hemodialysis is able to lower the concentration of drug at the end of the dialysis is recommended to introduce additional 500 mg.

Special instructions:

Heading therapy requires control over the functioning of the kidneys, liver, of hematopoiesis . Taking medication Amoxiclav during meals can reduce the severity of side effects from the digestive tract. The main component of the antibiotic therapy vary in the case of superinfection. In patients with sepsis may develop in the form bacteriolysis Jarisch-Herxheimer . Cross-allergic reactions are recorded in patients with a history of allergy to cephalosporins.

Drug Interactions:

Aminoglycosides, laxative medicines Glucosamine .   Antacids   reduce and slow the rate of absorption, unlike ascorbic acids. Bacteriostatic antibiotics   (chloramphenicol, macrolides, tetracyclines, lincosamides, sulfonamides) has an antagonistic effect and bactericidal antibiotics   ( rifampicin , Cycloserine, cephalosporins, vancomycin , Aminoglycosides) has synergistic effects. Amoxiclav able to increase efficiency anticoagulants , Reduce prothrombin index The synthesis of vitamin K to suppress intestinal flora. In appointing antikogulyantov control is required on indicators of blood clotting. Upon receipt of ethinyl estradiol increases the risk of bleeding "breakthrough". Amoxiclav reduces the effectiveness of oral contraceptives. Allopurinol , Diuretic drugs, NSAIDs, phenylbutazone increase the concentration of antibiotic in the blood. When using allopurinol increases the risk of a rash on the skin.