Description overdue on 18.08.2011
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This drug is a broad antibacterial spectrum. Fosfomycin - The active ingredient in Monurale. It has a bactericidal effect on the following Gram-positive bacteria : Staphylococcus saprophyticus, Staphylococcus spp, Enterococcus faecalis; such Gram negative bacteria : Serratia spp, Morganella morganii, Proteus mirabilis, Enterobacter spp., Pseudomonas spp., Klebsiella spp., Citrobacter spp., Esherichia coli. Monural principle of operation is that it inhibits the first step of the synthesis of microorganisms.
Fosfomycin from the intestine is absorbed quickly enough. The plasma protein does not bind, is not metabolized, mainly in the urine is accumulated. In the body, it dissociates into trometamol and fosfomycin. Its half-life period is two hours. This drug is mainly accumulated in the renal tissue. The effect appears after the first application.
Indications:
Monural usually prescribed for infections urinary system , Prevention of bacterial infections, nonspecific bacterial urethritis , Massive asymptomatic bacteriuria , Relapsing cystitis , Acute cystitis.
Mode of application:
Before use Monural, it must be dissolved in a third cup of water. The drug is recommended to use an empty stomach 2 hours before meals or at bedtime once a day. Before taking this drug need to empty the bladder.
Adult patients are usually given a single daily dose, which is 3a. Elderly patients may be applied twice Monural. For children older than five years, the permissible daily dose of 2g. For the prevention of urinary tract infections by surgery use a single package for three hours before surgery.
Side effects:
Individuals who use the drug, sometimes there is diarrhea, nausea, heartburn . Sometimes manifested in the form of hypersensitivity or allergic skin rash. In very rare cases, there backache, abdominal pain, sore throat, pain nonlocalized, dysmenorrhea Rhinitis, vaginitis.
Contraindications:
Monural contraindicated in children under five years of age, persons with sensitivity to fosfomycin and other components of the drug, people with congenital renal insufficiency.
Pregnancy:
Monural in pregnancy is not fully understood, as special research in this area has not yet been carried out. It must be remembered that fosfomycin can penetrate into breast milk and through the placenta. At the time of use of the drug breastfeeding must-stop. It is advisable to consult a doctor.
Monural Interaction with other drugs:
This drug should not be combined with metoclopramide As it can lead to reduced levels of fosfomycin in the urine and plasma.
Overdose:
If the dose Monural exceeded, it is necessary to carry out forced diuresis .
Product:
The drug release from the granules in sachets white to produce one oral solution. One packet contains either two or three grams fosfomycin.
Storage conditions:
Monural The drug should be stored only in a place closed to the access of children, light and moisture, where the temperature does not exceed twenty-five degrees Celsius. Monural can not be used after the expiration date.
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