Description overdue on 06/27/2014
- Latin name: Cefodox
- ATC code: J01DD13
- Active substance: Cefpodoxime (Cefpodoximum)
- Manufacturer: Pharma International, Jordan
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Cefodox (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Synonyms
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The composition includes the active agent Tablets cefpodoxime As well as a number of supporting components: iron oxide, croscarmellose sodium, Opadry OY-L white microcrystalline cellulose, magnesium stearate . sodium starch . sodium lauryl . silicon dioxide .
The composition of the powder used to prepare a suspension, the active agent includes cefpodoxime And optional ingredients: Simethicone emulsion . saccharin sodium . carboxymethyl cellulose . hydroxypropyl . dextrin, xanthan . citric acid . corn starch . microcrystalline cellulose . vanillin flavoring . saccharose . silica . flavor .
Product form
The antibiotic is available as tablets ( Cefodox 100 mg and Cefodox 200 mg ). The tablets have a film coating, the package contains 10 pieces.
Also means are made in the form of powder for suspension, which is contained in bottles of 50 ml. or vials host 100 ml.
Pharmacological action
Cefodox - a semisynthetic antibiotic That belongs to the third generation cephalosporin drugs. Its bactericidal effect on the body is caused by the ability to acetylate transpeptidase membrane cell walls of microorganisms. As a consequence, swept aside the violation of education cell walls of microorganisms.
High sensitivity is observed in many Cefodox Gram-negative organisms ( Escherichia coli . Klebsiella spp ., Proteus mirabilis . Haemophilus influenzae . Serratia spp. . Providencia spp. . Pseudomonas spp. . Citrobacter spp. ), As well as some Gram-positive microorganisms . Low sensitivity to the drug is fixed at the insensitive anaerobes. Not valid active ingredient of the drug in the majority of strains clostridia . Enterococci . Legionella . mycoplasmas . Chlamydia As well as strains resistant to methicillin staphylococci .
Pharmacodynamics and pharmacokinetics
There active drug absorption in the digestive tract of humans.
The bioavailability of drugs - About 52%. It falls into the most secret and tissues. The drug accumulates in most tissues and secretions. Cefpodoxime is accumulated in the muscles, lungs, kidneys, liver, and bone. It falls into the spinal fluid through the capsule abscesses. Cefpodoxime is not metabolized in the body. Excreted through the kidneys.
Indications
The drug is used in infectious diseases, which are caused by microorganisms that have a high sensitivity to Cefodox:
- tonsillitis . sinusitis . laryngitis . otitis . pharyngitis ;
- bronchitis . pneumonia ;
- pyelonephritis . cystitis (mild or moderate disease);
- infections of the joints, skin, soft tissue, bone tissue;
- proctitis . urethritis . cervicitis Having gonococcal origin.
Contraindications
Do not practice the use of drugs to people with hypersensitivity to the components of the drug.
Tablets are not indicated for children under 12 years of age.
The suspension is not administered to children under 5 months of age, as well as in patients with galactose intolerance, lactase deficiency or malabsorption of glucose and galactose.
Side effects
When treating Cefodox may appear some side effects:
- diarrhea , Vomiting, nausea;
- headache;
- itchy skin, rash;
- increased levels of urea and creatinine in plasma;
- increase in liver transaminases;
- leukopoiesis violations and thrombocytopoiesis;
- eosinophilia.
Instructions for use Cefodox (method and dosage)
Instructions on Cefodox provides that an antibiotic is taken by adults and adolescents who are over 12 years old, at a dose of 200-400 mg.
Instructions for use Cefodox 200 It provides that the infectious diseases of the genitourinary system of man and upper respiratory tract daily dose is 200 mg, bronchitis or pneumonia - 400 mg funds. Depending on the dosage pills are used 1-2 times a day. The duration of treatment depends on the nature of the disease and established a specialist. The elderly no need to adjust the daily dose Cefodox.
To prepare the suspension, you need to initially carefully shake the vial, then add cold water perekipyachennoy that the liquid has reached a point that is specified on the bottle. Add the water should be in two stages, periodically shaking the bottle to become a homogeneous mass. The homogeneous slurry can be applied five minutes after its preparation. Every time before taking should be carefully shake the bottle with suspension.
If appointed suspension Cefodox 100, the instruction says that the remedy should be taken with food. Interval between doses should be 12 hours. The suspension administered to children to five months of age, with the daily dose of the agent is 10 mg per 1 kg of slurry weight of the child. The maximum dose means a day - 400 mg. Take the drug should be in two stages, as the largest single dose of 200 mg.
Overdose
In case of overdose may include the following symptoms: vomiting, nausea, diarrhea. In people with renal failure, may occur encephalopathy Which disappears with decreasing levels of the active substance in the blood plasma. In case of overdose the stomach should be washed, hemodialysis and symptomatic treatment.
Cooperation
Under the influence of antacids and H2- receptor blockers reduce the absorption of the drug.
If at one time with Cefodox appointed nephrotoxic drugs, you need to regularly monitor kidney function.
In an application Cefodox with probenecid increases the level of cefpodoxime in the blood plasma of the patient.
Terms of sale
Sold in pharmacies by prescription.
Storage conditions
Tablets should be stored at a temperature not exceeding 30 ° C, keep away from children.
The prepared suspension should be stored at + 4-6 ° C.
Shelf life
Cefodox tablets can be stored for 2 years.
The resulting suspension can be stored for more than 14 days.
Cautions
People who have allergies to other notes cephalosporins, should be aware of the possibility of a cross-allergy to cefpodoxime. When referring to a history of hypersensitivity to cephalosporins should not prescribe the means, because the reaction can be severe, sometimes - lethal.
People suffering from diseases of the gastrointestinal tract, antibiotics should be prescribed with caution, as a violation of the microflora can trigger the development of diarrhea.
Prolonged treatment of cefpodoxime may experience an excessive increase in resistant organisms.
During treatment antibiotic dizziness may periodically occur, which in turn can affect the ability to transport and work with serious mechanisms.
Synonyms
Oreloks . Cefpodoxime .
Analogs Cefodox
Cefixime
Tseforal Soljutab
Pantsef
Klaforan
Supraks Soljutab
Ceftriaxone
Similar preparations - this drugs which contain the same active substance. In the pharmaceutical networks can buy analogues Cefodox - drugs Doktsef . Tsefpotek . Aksef . Zinatsef . Zotsef and others. However, self-medication prescribed by a doctor to replace its analogues should not be.
Babies
Cefodox tablets for children assigned only after they reach 12 years of age. Children after age 5 meyasyanogo appointed suspension Cefodox 100. This should strictly follow the instructions on Cefodox for children, as the reviews suggest that the most pronounced effect was observed with strict adherence to the designated physician treatment regimen.
During pregnancy and lactation
Since the full details of the study the effect of the antibiotic on the body of pregnant women are absent, pregnancy Cefodox appoint women only when absolutely necessary. Since the active substance accumulates in breast milk, the treatment means necessary to stop breast-feeding a baby.
Reviews Cefodox
Adult patients and parents who used Cefodox for kids, online reviews are left mostly positive. In particular, there is rapid action tools for infectious diseases of the upper respiratory tract, as well as bronchitis and other infections. The review deals with the rapid disappearance of symptoms - high temperature, pain and others.
Side effects after receiving the funds appear very rarely. As a negative impression is marked disadvantage in the use of the bottle with the suspension and the dispenser.
Price Cefodox where to buy
Cost Cefodox 200 (14 pcs.) In Russia is about 1600-1700 rubles. Cost Cefodox 100 in Ukraine (Kiev, Kharkov, Dnepropetrovsk, etc.) is an average of 130-150 UAH. Powder for suspension of 100 mg can be bought on average for 150 USD.
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