Description overdue on 04/10/2014
- Latin name: Argosulfan
- ATC code: D06BA02
- Active substance: Sulphathiazole silver (Sulfathiazole silver)
- Manufacturer: Jelfa S.A. (Poland) and "Valeant" (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
In 1 g of cream contains 20 mg silver salt sulphathiazole . Supporting base components: dihydrogen phosphate and sodium lauryl sulphate, methyl hydroxybenzoate, glycerol, water for injection, propyl, potassium hydrogen phosphate.
Product form
Argosulfan available as white cream with a pink tinge in the box on 15 and 40 grams in packs of cardboard.
Pharmacological action
Argosulfan ointment has antimicrobial effect, promoting rapid healing of wounds of various etiologies ( purulent lesions . trophic ulcerative changes . burns ). The drug relieves the symptoms of pain, prevents infection of the wounds, reduces healing time. In some cases, during treatment with the drug is not necessary to Transplant skin flaps.
Argosulfan cream contains in its composition one of sulfonamides - sulphathiazole, which has a pronounced antibacterial effect by acting on bacteria bacteriostatic. The spectrum of action of the active ingredient - gram-positive and gram-negative bacteria flora. The main mechanism of the antibacterial effects aimed at suppression of reproduction and growth of microorganisms by inhibiting the activity of digidropteroatsintetazy and competitive antagonism with PABA. The reaction changes the process of synthesizing dihydrofolic acid and its main metabolite of tetrahydrofolic acid, which is vital for synthesizing pyrimidine and purines microorganism.
Thanks silver ions sulfanilamide enhanced antimicrobial effect by binding to the DNA of the bacterium and subsequent inhibition of microbial growth and division of cells. Additionally, the silver ions inhibit the sensitizing activity of sulfanilamide.
The optimum pH and hydrophilic base moisturizing cream to the wound, accelerating healing, pain relief.
Pharmacodynamics and pharmacokinetics
Silver salt sulphathiazole has mild solubility, making the concentration of the main active component on the surface of the wound at the optimum support required level. The drug has no toxic effects due to the minimal resorption. A small fraction of silver salt enters the systemic circulation, and then acetylated hepatic system. The larger area of application of creams, the higher the absorption sulfathiazole.
Indications
The drug used in the treatment of patients with damage to the skin:
- burns;
- Frostbite (all degrees);
- bedsores;
- trophic ulcerative lesions;
- household injuries (cuts, abrasions);
- contact dermatitis;
- purulent infected wounds;
- eczema;
- microbial dermatitis;
- stafilodermiya;
- streptoderma.
Contraindications
- a state of shock at the extensive burns;
- Individual hypersensitivity;
- congenital form of deficiency of glucose-6-phosphate dehydrogenase;
- lactation.
The drug is not prescribed for children until 2 months of life, premature babies because of the high risk of a nuclear form jaundice .
Side effects
Cream does not change the color of the skin. Long-term therapy can cause systemic reactions (desquamative dermatitis, changes in the work of the blood). Rarely recorded allergic responses . The drug is well tolerated, subject to the recommendation of a physician and following the instructions. Compared with drugs with similar effects, adverse reactions are least likely to give an ointment Argosulfan.
Instructions for use (method and dosage)
The drug is not intended for ingestion, allowed only outside use. The cream can be applied to open wounds, allowed to use the special occlusive dressings. The drug is applied to clean skin, aseptically antiseptics . In the presence of exudate recommend pretreatment of the skin with a solution boric acid Of 3% or solution chlorhexidine 0, 1%.
Instructions on Argosulfan: the medication is applied a thin layer of 2-3 mm before the complete closure of the wound or until ready to transplant skin graft. Daily recommended 2-3 treatments. Daily can be applied not more than 25 g of ointment. The duration of a course of treatment - 2 months. If prolonged, continuous therapy is required mandatory control of functional parameters of the liver and renal system.
Overdose
No reliable data are not available.
Cooperation
In one area of the skin can not be used simultaneously Argosulfan and other medicines. Efficacy sulfathiazole silver is reduced by treatment procaine , Drugs folic acid and its structural substitutes.
Terms of sale
Over the counter.
Storage conditions
Away from the light, sunlight. The preferred temperature range of 5-15 degrees Celsius. Store in a dry place.
Shelf life
2 years.
Analogs Argosulfan
Ebermin
Available only structural analogue of the drug - Sulphathiazole silver . Analogs of the pharmacological effect:
- Streptocide;
- Dermazin;
- Sulfargin.
During pregnancy (and lactation)
During the period of gestation pregnancy Argosulfan can be applied only in cases of urgent need, for example, if damaged skin area of more than 20%. Breastfeeding It advised to stop because of partial absorption of the drug.
Reviews Argosulfane
In medical practice, the cream has proven itself as an excellent tool in the treatment of burns a wide area. Subject forums and medical portals, where ordinary patients to share their experiences, contain only positive reviews Argosulfane. Young mothers also leave their feedback on ointments, and point to its good tolerability young children, high efficacy in the treatment of abrasions, cuts and wounds.
Price Argosulfan where to buy
The drug is sold in the pharmacy. Price ointment Argosulfan in Ukraine is 72, 50 UAH per tube '15 cream in tubes of 40 g is 103, 55 UAH. Price Argosulfan in Russia: tube 15 g - 220 rubles., 40 g - 350 rubles.
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