Description overdue on 08/09/2014
- Latin name: Polydexa
- ATC code: S02CA06
- Active substance: Dexamethasone + Neomycin + Polymyxin B (Dexamethasone + Neomycin + Polymyxin B)
- Manufacturer: Laboratoires Bouchara-Recordati (France)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Polydex (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Polydex children
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 ml ear drops It comprises:
- neomycin sulfate - 10 mg (6500 units);
- sulfate polymyxin B - 10,000 units;
- dexamethasone sodium metilsulfobenzoat - 1 mg.
And Excipients :
- lithium chloride;
- thiomersal;
- citric acid;
- sodium hydroxide;
- polyethylene glycol 400;
- polisobat 80;
- distilled water.
Nasal sprays as active components acting in its composition is:
- neomycin sulfate, 6500 units / ml;
- metasulfatbenzoat dexamethasone sodium - 250 ug / ml;
- polymyxin B sulfate - 10000 U / ml;
- phenylephrine hydrochloride - 2, 5 mg / ml.
Several different auxiliary substances and the composition of the nasal spray, ear drops:
- methylparaben;
- lithium chloride;
- lithium hydroxide;
- lemon acid;
- macrogol 4000;
- polysorbate 80;
- purified water to the required amount of drug.
Product form
Polydex - combined preparation, which comes in pharmacies in two fundamentally different pharmacological forms:
- Drops in the ears in dark glass bottles at 10, 5 ml. In addition to the drug in the carton and put dosing pipette.
- Nasal Spray - A clear, colorless liquid in bottles of 15 ml with a special spray. The carton accommodates one vial with the drug.
Pharmacological action
The pharmaceutical preparation is Polydex combined a drug which in its therapeutic effect is classified as anti-inflammatory and antimicrobial . Existing components that make up the ear drops, in particular, neomycin, and polymyxin, can suppress these types of pathological microorganisms as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeroginos, Haemophilus influenzae . Unfortunately, resistance to the influence of the pharmaceutical preparation remained some species of streptococci, staphylococci, and anaerobic bacteria.
Nasal Spray has as wide a therapeutic effect on the nasal mucosa, as well as the pharmaceutical form of the drug for the ears. Also, its beneficial properties are complemented phenylephrine , Vasoconstrictor effect which reduces the nasal congestion and greatly facilitates nasal breathing.
Pharmacodynamics and pharmacokinetics
No significant pharmacokinetic studies faculties drug has not been as Polydex used topically and has a very low degree of absorbability and in peripheral arterial blood flow (systemic effects occur only at a significant increase in the dosage or duration of the course is extremely conservative therapy).
Indications
Ear drops are used in the following pathologies:
- outer and middle otitis (only if there is no defect in the eardrum);
- infected eczema auditory meatus.
Polydex with phenylephrine as a nasal spray used for:
- inflammatory and infectious diseases of the nose, throat and sinuses;
- acute and chronic rhinitis ;
- nasopharyngitis ;
- sinusitis .
Contraindications
- increased individual sensitivity to the constituent components of the pharmaceutical formulation;
- inherited or acquired intolerance active substances of the drug;
- Infectious or traumatic injury of the tympanic membrane;
- abandoned coal glaucoma or suspicion of the pathology;
- period pregnancy and breast-feeding ;
- Children up to age 2, 5 years;
- disease entities caused by viruses varicella or Herpes ;
- albuminuria or urinary retention and kidney disease, which lead to these pathological conditions;
- propensity to ventricular tachycardia type pirouette or reception of pharmaceuticals that contribute to the appearance of this anomaly.
Side effects
The adverse effects of the treatment of ear drops appear only in isolated cases. There may be Local allergic reactions , eg:
- hives;
- itching;
- rash.
So how Nasal spray accommodates large number of active components and their therapeutic effects are realized through the mucosa, the manifestation of adverse effects is more likely. As in the case of ear drops, especially, there may be similar allergic reactions Which are complemented by a sense dryness in the nasal passages. Adverse effects systemic nature only possible with prolonged course of conservative treatment or when doses of a pharmaceutical preparation, greatly exceeding the prescribed instructions. In this case can be observed:
- headache;
- sleeplessness;
- high blood pressure;
- tachycardia;
- tremor;
- the reaction of the microvasculature in the form of redness or paleness.
Instructions on Polydex (method and dosage)
Ear drops are widely popular among patients ENT hospital, as this form of the drug is extremely easy to use, has a meager list of side effects occurring only in isolated cases. Also, reliable data on overdose Polydex ear in the medical literature has not been described.
Instructions for use Polydex does not differ in pediatric patients and adults. So dosage children as older patient population is 1-2 drops into each ear auditory meatus 2 times per day. When indicated, and severe disease in adults, the amount of the drug may be increased to 5 drops. Before the recommended bit manipulation warm drug .
Course Length Conservative therapy is 6-10 days.
Spray with phenylephrine It applied intranasally. Use it as easily as ear drops. During manipulation of the bottle with a pharmaceutical drug must be kept upright And head tilted somewhat forward, as active ingredients will irrigate a large area of the mucous membranes of the nasal cavity.
Dosage drug injection is 1 to 3 times per day in each nostril. For adults and children 15 years after the frequency of use of the pharmaceutical preparation can be increased up to 5 times a day, if required therapeutic indications.
A course of treatment Usually it takes 5 to 10 days.
Overdose
Cases of overdose ear drops in the medical literature are not described. Prolonged therapy with nasal sprays or using doses exceeding the prescribed instructions, can lead to systemic side effects.
Cooperation
Drug interactions, rendering clinical effects, develops due to the content of phenylephrine nasal spray. Simultaneous use of the pharmaceutical form with Polydex guanetidinom increases hypertensive the effect of active components of a spray. Also, due to the reduction of sympathetic tone can be observed long mydriasis . Therefore, when the absolute testimony to the use of these drugs combined therapy is recommended constant supervision of the attending physician and conduct appropriate clinical tests.
Terms of sale
The drug in the pharmacy is released only on presentation of the appropriate form of the receptor.
Storage conditions
Keep a pharmaceutical preparation to be at a constant temperature mode or above 25 degrees Celsius and in the reach of direct sunlight.
Shelf life
3 years
Cautions
Ear drops are not recommended to use in the presence of perforation of the eardrum . In this case, there is the possibility of toxic effects of the active components of the drug to the auditory or vestibular system.
With extreme caution should be used when a drug is suspected fungal or viral etiology disease. It is recommended that more research before starting a course of conservative therapy.
Among the active components of the pharmaceutical preparation has dexamethasone Biologically active substance which, when Doping Control It can give a positive result in the duration of treatment or dosages considerably higher than those specified in the instructions (operating components can have systemic effects).
It is impossible to say for sure: Polydex - an antibiotic or not, but the question often pops up in the pharmaceutical forums dedicated to the topic. Of course, as part of the drug components are active antibiotic nature, for example, polymyxin B, or neomycin, however, inherently or nasal spray or drops to the ear is not classified as an antibiotic. It is also a positive feature of the drug is possible to simultaneously use it with antibiotics for systemic effects, if there are to the relevant medical evidence, confirmed by the attending physician.
Analogs Polydex
Kandibiotik
The drug is known for some unique in the market of pharmaceutical products in otolaryngology. There is only one such medicine - drops Maksitrol Belgian production. Active components which also include neomycin and polymyxin. The price is slightly higher counterparts, as they presented a wide range of dosage forms, but in the domestic pharmacy kiosks, as a rule, supply drops to 5 ml.
Polydex children
The pharmaceutical formulation is often used Polydex in pediatric patients As well as inflammatory diseases of the nose and the ear occur in children throughout. Once a small child crosses the threshold of the house, starting cough , Snot, colds . ear pain and other manifestations rhinitis . sinusitis . otitis or other inflammatory diseases. The medicament as droplets or a nasal spray for children can be used to achieve 25 years . More significant regulations guide to the medicine does not, that is applicable pharmaceutical preparation is extremely easy, you do not even need to undergo any special training courses or knowledge of a medical nature.
Separately, it is noted that price the drug is not very upset parents and does not hit the family budget. Because keep in stock the drug Polydex - a simple task. Do not forget about Recommendations in the pharmaceutical product. Most thematic forums praise Polydex like substance that allows to record a short course of conservative therapy to eliminate the problem of so bored rhinitis, sinusitis or otitis media in adults category of patients and in younger.
From the medical point of view also approved receiving Polydex children. Reviews qualified experts confirm that the active ingredients of the drug to quickly and effectively get rid of the inflammatory pathology even in pediatric practice, when the young body is not enough to form their own immune systems.
Polydex during pregnancy (and lactation)
Use of a pharmaceutical preparation in pregnancy and during breastfeeding is strictly contraindicated Because the effect of active ingredients on the developing child's body has not been studied properly.
Reviews Polydex
Ear drops Polydex enjoy a good reputation in the relevant discussion forums and pharmaceutical internet resources. Most patients undergoing a course of drug data, leave very positive feedback, encouraging active use drops for conservative treatment of diseases of the outer and middle ear.
Reviews of doctors from a professional point of view, confirm that the pharmaceutical Polydex actually ranked first among the measures conservative therapy in otolaryngology. As ear drops and nasal spray effectively eliminate the cause of the inflammatory process underlying all disease, and because the use of such a drug is classified as etiologic sanitation.
Not only adults, but children are happy Polydex after treatment, because the pharmaceutical returns dryness of the nose, allows nasal breathing freely, to hear in full force and the most important thing - once again playing with friends on the street after some 6 10 days after conservative therapeutic course minimum in the art of pharmaceutical preparations.
Price Polydex where to buy
Price ear drops in the Russian Federation is about 200-220 rubles. Buy this form pharmaceutical in Ukraine can be of equivalent cost 75-85 hryvnia.
Nasal Spray in the pharmacy of the two countries can be bought for 240 rubles, or 80 hryvnia.
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