Nimesulide

Description overdue on 04.01.2013

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Non-steroidal, prostivovospalitelnoe means . The drug has antiplatelet, antipyretic, analgesic and anti-inflammatory effects. The principle impact is directed to the inhibition of the process of synthesizing prostaglandins   in inflammatory foci for the selective inhibition of cyclooxygenase-2. Nimesulide issued in the form granules, suspensions, in tabletirovannoj dosage form.

Indications:

Instructions for use recommends that to appoint Nimesulide at an osteoarthrosis, rheumatoid arthritis, when bursitis, tendinitis, arthritises of different genesis. The drug is prescribed for the relief of acute pain in myalgia, algodismenoree , Toothache arthralgia , Headache, in the postoperative period. The drug has no effect on the progression of the disease, it is effectively used to reduce the severity of inflammation, to reduce pain, and as a symptomatic therapy.

Contraindications:

Nimesulide is not indicated in patients with erosive and ulcerative diseases of the digestive tract, bronchial asthma, intolerance to drugs of NSAIDs, and other cerebrovascular bleeding at ulcerative colitis , Inflammatory bowel diseases, Hemophilia Crohn's disease, relapsing forms of polyposis and paranasal sinuses of the nose, with active bleeding from the gastrointestinal tract, in blood coagulation disorder. The drug does not apply to progressive renal pathology system in the form of severe renal insufficiency, with hepatotoxic reactions during treatment with nimesulide in history, with active liver disease system in the form of chronic decompensated Heart Failure At gestation pregnancy, hyperkalemia , Children until 12 years old, while the use of other drugs gapatotoksicheskih, since coronary artery bypass grafting .

Side effect:

Use of the drug Nimesulide may cause some side effects. Central nervous system: Reye's syndrome Headache, "nightmarish" dreams, fear, anxiety, dizziness, nervousness. Skin:   increased sweating, itching, rash, dermatitis, erythema, angioedema , Toxic epidermal necrolysis, erythema multiforme exudative, hives , Stevens-Johnson syndrome. Urinary system: interstitial nephritis , Renal failure, hematuria, dysuria, urinary retention, oliguria . The digestive tract:   cholestasis, gastritis, flatulence, constipation, increased levels of liver enzymes, bleeding from the gastrointestinal tract, vomiting, nausea, diarrhea syndrome, jaundice, fulminant hepatitis, epigastric pain, perforation, and ulcerative lesions of the stomach wall. Bodies of blood:   increase in bleeding time, hemorrhage , Purpura, pancytopenia, thrombocytopenia, anemia. Respiratory system: bronchospasm , Shortness of breath, possible aggravation of pre-existing asthma. Senses:   violation of visual perception in the form of blurred vision. Cardiovascular system:   "Tides" of blood flow to the facial skin, fall in blood pressure, heart palpitations. It is also noted hypothermia, weakness, increased levels of potassium ions.

Mode of application:

Nimesulide is taken twice a day, 50-100 mg, preferably after the meal. In severe renal pathology of the daily dose is 100 mg. The medicament is recommended as possible to apply the minimally short courses in minimal, but effective doses.

Special instructions:

Patients during treatment with Nimesulide is recommended twice a month to exercise control over the state of the hepatic system. At higher levels of liver enzymes, the emergence of itching, rash, epigastric pain, jaundice, dark urine when treatment ceased. Reviews about the drug Nimesulide disclose a violation of visual perception in patients taking the drug for a long time. When you register any changes in the organs of vision therapy is stopped, there is a compulsory full eye examination . Description of the drug indicates a potential fluid retention in the body that requires caution in patients with hypertension. Do not appoint Nimesulide together with other medicines from the group of NSAIDs. The drug can not replace a preventive effect antiplatelet agents Despite the marked reduction in the rate of aggregation of platelets. The drug is not prescribed to women planning pregnancy because of the negative impact on the fertility . Nimesulide can have an impact on the management of transport.

Drug Interactions:

Risk hepatotoxic effects   significantly increased, while the use of hepatotoxic drugs. The medicament raises efficiency anticoagulants. When receiving furosemide there is a decrease of severity of its diuretic effect. Nimesulide displaces salicylic acid , Fenofibrate and furosemide of the links with proteins. The preparation increases the concentration of lithium ions in the blood plasma. The drug is able to increase the toxicity of methotrexate, enhance nephrotoxic effects of cyclosporine. The risk of gastrointestinal bleeding increases with concurrent therapy with selective serotonin reuptake inhibitors, corticosteroids.