Description overdue on 09/14/2014
- Latin name: Aktiferrin; Aktiferrin compositum
- ATC code: B03AE10
- Active substance: Iron sulfate + serine (Ferrous sulfate + Serin); Iron sulfate + Folic acid Serine + (Ferrous sulfate + Serin + Folic acid)
- Manufacturer: Merkle GmbH, Germany
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Aktiferrin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The composition drops Aktiferrin (100 ml) contains 4 grams of 72 ferrous sulfate heptahydrate ; 3, 56 grams serine + Additional ingredients ( potassium sorbate, ethanol, raspberry cream and flavorants, water, ascorbic acid, invert sugar syrup ).
One capsule: 113 mg 85 iron sulfate monohydrate + 129 mg serine + Adjuvants ( lecithin, soy bean oil, gelatin, beeswax, glycerol, rapeseed oil, sorbitol, black and red iron oxide ).
100 ml of syrup have 3, 42 g ferrous sulfate heptahydrate ; 2, 58 g of serine + Sugar syrup, vitamin C .
raspberry flavor, water, ethanol, creamy flavor .
The composition includes capsules Aktiferrin Compositum 113, 85 mg iron sulfate monohydrate ; 129 mg serine ; 0 5 mg folic acid + Adjuvants ( beeswax, soybean lecithin, rapeseed oil, soybean oil, sorbitol, gelatin, black iron oxide, glycerol, titanium dioxide, yellow iron oxide, titanium dioxide, iron oxide brown, shellac, red iron oxide, butanol, methanol, ethyl acetate ).
Product form
Drops Aktiferrin produced as a clear yellow-green solution having a raspberry aroma and taste, in vials of 30 ml.
Also, the drug produced in the form dark brown capsules in a gelatin shell capsule inside - a light beige oil. Means in packs of 20 and 50 pieces.
Syrup Aktiferrin - transparent yellow-green, raspberry scent has a capacity of 100 ml.
Aktiferrin Compositum - Capsules light brown on one side, dark brown on the other hand, tablets white inscription «Aktiferrin F», inside - greyish-yellow paste. The package contains 30 pieces.
Pharmacological action
The product fills an iron deficiency.
Pharmacodynamics and pharmacokinetics
For the normal functioning of the body is a very important element iron. The substance is included in the composition Hemoglobin . cytochromes and myoglobin , Is involved in the transport of oxygen to all the organs and tissues, a stimulant erythropoiesis . About 60% of the material is part of the red blood cells (hemoglobin) 1 gram - reticuloendothelial system of the liver and spleen . Iron is found in bone marrow Every day there is about 25 mg of material.
Alpha-amino acid serine improves the absorption of iron, it requires a much smaller dose of iron. It quickly spread throughout the body and is absorbed.
Folic acid involved in the synthesis of amino acids . nucleic acid and nucleotides Also takes part in the erythropoiesis . The acid is very useful for pregnant women, protects against various teratogenic factors.
Absorption occurs in active components duodenum and the upper part small intestine . It absorbed about 15% iron. However, if the patient is very low hemoglobin, and upgraded erythropoiesis , This figure may reach 50%. After 3 hours, reaches its maximum drug concentration in plasma.
Even in circulating iron bound to the enzyme transferrin and transferred to the necessary tissues and organs. The maximum amount of unreacted enzyme iron - 12 mg.
AT liver . bone marrow and spleen the process of deponatsii . Iron is able to penetrate through placenta and into the breast milk.
Every day, the body loses up to 1 mg of iron, this is particularly intense in women during menstruation. After the collapse of hemoglobin iron, liberated in the process may be re-used for the synthesis of a new oxygen carrier.
Indications
Funds designated for elimination of iron deficiency in the body, with a lack of folic acid or serine.
Also, the drug is often used in pregnancy And in other conditions where increased requirement for iron.
Contraindications
The drug is not prescribed:
- at allergies on the components of the drug;
- at hemochromatosis and gemosideroze ;
- at anemia (including lead, sideroahresticheskaya, thalassemia, hemolytic and caused by lack of B12 );
- if you are taking other products containing iron;
- in case of serious diseases GI ( stenosis . ileus );
- intolerance of fructose or galactose;
- If there are regular Blood Transfusion .
Side effects
You may experience:
- constipation . flatulence . diarrhea , Abdominal pain, nausea, bitter taste in the mouth, loss of appetite;
- weakness headaches . dizziness , rarely - encephalopathy ;
- pain or pressure in the chest, throat pain or dental pain;
- allergies , Skin rash, anaphylactic shock .
If any malfunctions GI We should try to reduce the daily dose, the symptoms should disappear.
Instructions on Aktiferrin (method and dosage)
The treatment regimen should be determined by means of the attending physician based on the results of analyzes and monthly monitoring.
Take the drug less than two months does not make sense, every 4 weeks should be to make the control parameters.
Drops Aktiferrin, instructions for use
Dosage is calculated as 5 drops drug per kg weight of the patient, means for taking three times a day:
- Baby daily dose of 30-45 drops per day;
- for preschoolers - 75 100 drops;
- for students - 150 drops.
To open a bottle of medicine, lightly press on it and turn it in the direction of the arrow after application - tightly closed.
Instructions on capsules
Capsules do not chew or bite through , Washed down with water or better orange juice, half an hour before meals.
The daily dosage for adults is 1 tablet - 2 times a day, for children - the same amount once a day.
Instruction in syrup
To calculate the daily dose for individuals older than two years, should be calculated on 5 ml of the preparation per 12 kg of body weight.
Typically, students take 5ml 3 times a day, preschool children - 5 ml, 2 times per day.
Capsules Aktiferrin Compositum
It is also taken as a whole, before eating, drinking juice, it is desirable that the juice contains a lot of vitamin C.
Adults and persons weighing more than 50 kg drink 2 capsules per day. For children the dosage - one capsule per day.
Overdose
Most high probability of overdose in children. Even when taking a gram may endanger the child's life, and the drug should be well hidden.
Symptoms of overdose are: nausea, diarrhea , Vomiting, drowsiness . shock and collapse vessels. After 5 hours after the first symptoms can be seen improvement, but after 12 to 48 hours a clinical picture may significantly worsen (shock, toxic liver failure . coagulopathy . Cheyne Stokes breathing ).
Because of toxic hepatitis you may receive jaundice May occur disorders of the nervous system, even coma. If treatment was performed in time, the probability of death is greatly reduced.
To begin to wash out the stomach Bicarbonate or phosphate p-s , Then take the milk and raw egg.
It may be assigned deferoxamine (1-2 grams) intravenous drip. And one injection the next day.
Clinically proven ineffectiveness Hemodialysis You may use peritoneal dialysis .
In very severe conditions may designate Dimercaprol .
Cooperation
Tetracycline . Ciprofloxacin . norfloxacin . ofloxacin . levofloxacin . penicillamine . carbidopa . Levodopa and methyldopa under the influence of the drug may be poorly absorbed by the body, require dose adjustment.
When combined with thyroxine and zinc iron salts are less absorbed in the stomach.
Citric and ascorbic acids increase the degree of absorption of iron.
Calcium, magnesium, chloramphenicol , Cholestyramine, antacids Containing aluminum, magnesium, calcium or bismuth reduced iron resorption.
When combined with glucocorticosteroids the process can be enhanced erythropoiesis .
Vitamin E reduces the activity of iron in the body, especially in children.
Terms of sale
We need a recipe.
Storage conditions
Do not allow children to hand. Store at a temperature not exceeding 25 degrees.
Shelf life
Capsules - 4 years.
Syrups, drops - 2 years.
Cautions
When receiving the drug should use caution to patients asthma . rheumatoid arthritis . hepatitis . alcoholism , Liver and kidneys, diabetes .
You can not drink tablets or capsules of black tea, milk and coffee. Also, do not take the parallel (span of two hours) of raw grains, solid food, bread, eggs and various dairy products.
Perhaps staining of feces black. To avoid staining black teeth, the teeth must be cleaned after taking medicine, drink, syrup or drops undiluted.
Analogs
Fenyuls
The closest analogues: Sorbifer Durules, Ferroplekt, Maltofer, Totem, Gemoferon, Ranferon-12, Feron Forte Gemsineral - TD .
What's better Maltofer or Aktiferrin ?
Maltofer Unlike the original drug contains polymaltose complex of ferric iron hydroxide and it has certain advantages over the divalent iron . For example, the probability of poisoning in overdose greatly reduced, means less toxic, better tolerated, does not interact with food and other drugs, enamel does not turn black. However Aktiferrina value slightly lower than that of an analogue thereof. Judging by the reviews on the Internet, both agents are effective. The frequency of adverse reactions from both drugs is the same.
During pregnancy and lactation
Often the drug is prescribed to pregnant women. In any case, the application of the funds should be coordinated with the doctor. The drug passes into breast milk.
Reviews Aktiferrin
In preparation generally good reviews. Well tolerated, side effects are rare. Many people like the relatively low cost and a variety of dosage forms. Many more came Aktiferrin Compositum because it is better absorbed.
Reviews Aktiferrin for infants
Means well raises the level of hemoglobin, the child becomes more active, improves skin color. However, side effects do occur, poorly satisfied with this content with clothes.
Price Aktiferrina where to buy
Price drops Aktiferrin is about 247 rubles per 30 ml.
The cost of 50 capsules Aktiferrina - 275 rubles.
Price syrup - 198 rubles per 100 ml.
30 capsules Aktiferrin Compositum cost 241 rubles.
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