Rimantadine

Description overdue on 12.03.2012

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Antiviral . It has a detoxifying and immunomodulatory effects. The drug is effective against herpes simplex virus, Influenza A virus , The causative agent of tick-borne encephalitis. Due to the polymer structure is achieved by prolonged circulation of a main component of the drug in the body, which provides a prophylactic defense against activities of the virus. The mechanism of action of the drug is aimed at the suppression of the first stage of a particular early reproduction, inducing production of gamma and alpha interferon. Rimantadine increases the functional activity of lymphocytes. Active ingredient raises the pH of endosomes surrounding the viral particles have penetrated into the structure of the cell. The drug inhibits the transcription of the viral genome. When medication Rimantadine prophylaxis in reducing the risk of infection with influenza virus. The drug is available in the form of a syrup, a tablet form.

Indications:

Rimantadine is prescribed for Type A influenza prevention and treatment. The drug is contraindicated in children under one year of life, during pregnancy and during breast-feeding. In severe renal and hepatic disease, epilepsy   drug is administered with caution.

Side effect:

Digestive system:   vomiting, stomachalgia , Anorexia, dry mouth. Nervous system:   excessive fatigue, excessive nervousness, headaches, attention deficit disorder, vertigo.

Mode of application:

Rimantadine taken after meals is recommended to drink a sufficient amount of liquid. Prevention of viral disease: twice a day at 100 mg. Treatment of Viral Infection: in 5-7 days to twice a day at 100 mg. In the pathology of renal drug is taken once a day.

Special instructions:

Taking medication can lead to the development of drug-resistant viruses. Compared with amantadine formulation is less toxic and has a higher clinical efficacy. Antitoxic effect   expressed with influenza B. Rimantadine take prophylactic if common viral infections in communities, during an epidemic. The drug affects the performance of complex work, driving.

Drug Interactions:

Acetylsalicylic acid   Paracetamol and reduce the maximum concentration of drug rimantadine 10%. Simultaneous reception cimetidine   It leads to a drop in the clearance of the active component of 18%.