Description overdue on 11/11/2014
- Latin name: Neurobex Neo
- ATC code: A11JA
- Active substance: Vitamin complex
- Manufacturer: Balkanfarma AT-Dupnitsa, Bulgaria
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Neurobeks Neo (The method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
The drug consists of active substances: ascorbic acid - 175 mg thiamine nitrate - 50 mg, riboflavin - 25 mg, calcium pantothenate - 25 mg, pyridoxine hydrochloride - 10 mg, folic acid - 500 mg, cyanocobalamin - 5 mg, nicotinamide - 100 mg.
Additional ingredients: potato starch, magnesium stearate, colloidal anhydrous silica, talc and calcium hydrogen phosphate.
The body and cap of the capsule consists of: dye FD & C Red 3 dye D & C Yellow 10, gelatin, titanium dioxide (E171).
Product form
Available Neurobeks Neo in gelatin capsules, orange-black-containing powder. The package includes a 30 or 60 pieces.
Pharmacological action
Neurobeks Neo - it combined multivitamin preparations Comprising ascorbic acid and B vitamins .
Pharmacodynamics and pharmacokinetics
Effect of the drug cause the properties of vitamins in its composition.
After receiving the capsules one of the active components ( thiamine) phosphorylated, resulting in a kokarboksilaza . This material is coenzyme Who is a member of many enzyme reactions. Thiamine is required for carbohydrate, protein and fat metabolism, carrying nerve impulses in the synapses. The lack of this substance leads to excessive concentration Breast and pyroracemic acid That can induce the development of polyneuritis . Wernicke's encephalopathy, Korsakoff's syndrome, disorders of the heart . GI and other.
Pyridoxine actively supports the function of the nervous system. As a result of the phosphorylation vitamin B6 produced a coenzyme that is necessary for high-grade amino acid metabolism and other enzymes Located in neuronal tissues. In addition, pyridoxine is involved in the biosynthesis of neurotransmitters : histamine, norepinephrine, epinephrine, serotonin, gamma-aminobutyric acid. Call deficit vitamin B6 could malnutrition, disruption of the gastrointestinal tract, the use of a number of medicines that are related to its antagonists. This can lead to the development of glossitis, stomatitis, convulsive state, peripheral neuritis, anemia and other irregularities.
Cyanocobalamine promotes normal blood formation, maturation of red blood cells and the flow of biochemical reactions that provide the full life of the body: the production nucleic acid Protein, transport of the methyl groups, metabolism of amino acids, carbohydrates and lipids. It was found that the substance has a positive effect on the nervous system, the development and replication of cells. Lack B12 manifested disorders of the hematopoietic and nervous system, causing severe complications.
Riboflavin It is an important catalyst in the process of visual perception and cellular respiration. After oral administration, noted cooperation riboflavin and ATP, thereby forming flavin adenine nucleotides and flavin mononucleotide- . These substances are coenzymes that carry hydrogen and regulate the redox processes. Also noted participate riboflavin a in the processes of protein, carbohydrate and fat metabolism, maintaining the full visual function and synthesis Hemoglobin . Lack of vitamin B2 can cause giporiboflavinoz, and in consequence, and ariboflavinoz . When giporiboflavinoze decreased appetite, decreased weight, develops weakness, headache , Burning skin, stinging eyes, night blindness, pain in the corners or lower lip. Further development of the disease is accompanied by cracks, or crusts on the lips in the form of angular stomatitis, dryness and redness of the tongue, seborrheic dermatitis in the nasolabial folds, the emergence of photophobia, conjunctivitis, blepharitis. It is also possible to increase the gastric secretory function, increased biliary excretion, facilitating absorption of carbohydrates in the small intestine.
Nicotinamide essential for tissue respiration, metabolism of fats, carbohydrates and amino acids.
Calcium pantothenate It is one of the components coenzyme A Which is involved in the acetylation and oxidation of fats and carbohydrates, development of bile acids and hormones.
Folic acid important for full synthesis of erythrocytes in carbohydrate metabolism, and division of cells. With a lack of folic acid observed inhibition of phase transition megaloblastic hematopoiesis in normoblasticheskuyu what causes megaloblastic anemia.
Ascorbic acid It is a regulator of redox processes involved in the synthesis of collagen, catecholamines, steroids and folic acid metabolism. This material is necessary for the formation of bones and teeth, the assimilation of mineral components, such as: iron, beta-carotene, calcium and Vitamin E . Noting the importance of vitamin C in the regulation of blood coagulation, stimulating the blood, vascular permeability. Besides that, ascorbic acid It is the strongest antioxidant , Reduces the effect of free radicals, which cause damage to healthy cells. It also improves the body's resistance to external adverse factors, the body's resistance to viral and bacterial infections. Reduced concentration histamine Which is a mediator of inflammation, thereby alleviated the symptoms of the common cold - rhinitis . watery eyes, redness of the conjunctiva. Vitamin C enhances mental and physical performance, activation of the basal metabolic rate.
All the components that make up the Neurobeks Neo, are water-soluble vitamins, so their accumulation in the body is excluded.
Absorption thiamine and pyridoxine It occurs in the upper intestine, and then observed their uniform distribution in the body. The degree of absorption is directly related to the dosage. The absorption process cyanocobalamin determined by the presence of internal factors in the upper intestine and stomach. Delivery of substances into tissues performs transport protein transcobalamin II.
As a result, quick and easy absorption riboflavin quite unevenly distributed within the body - most marked in the myocardium, kidneys and liver.
Absorption Folic acid It occurs in the form of simple hydrolysates. A minor portion of the enzymes that perform hydrolysis, arranged in 12 pёrstnoy and small intestine. The substance penetrates into almost all body tissues. In this third substance as methylfolate stored in the liver.
Flash dispersal nicotinamide It is derived from the digestive tract, and then the substance is evenly distributed in the tissues and organs.
To ascorbic acid characterized by a rapid absorption in the intestine. Then the circulation of vitamin C is noted in the composition of the blood plasma, and the concentration of glandular tissue. The bulk concentration of a substance found in the tissues, platelets and lymphocytes .
Calcium pantothenate also easily and rapidly absorbed from the digestive tract, and then concentrated in heart, kidney and liver.
Metabolism thiamine, pyridoxine and cyanocobalamin in the liver. The process of metabolism and biotransformation folic acid not fully understood. Metabolism nicotinamide It occurs as methylation, resulting in formation of inactive metabolites . The metabolism ascorbic acid formed oxalic acid and other water-soluble metabolites.
Withdrawal of the drug is almost through all the organs of the excretory system. Pyridoxine and thiamin output by the kidneys when taking high doses - through the intestines. Withdrawal cyanocobalamin It occurs mainly in the bile, riboflavin, nicotinamide, ascorbic acid and calcium pantothenate - The urine in unchanged form or in the form of metabolites.
Indications
Neurobeks Neo administered in combination therapy of various conditions and diseases:
- asthenic syndrome, chronic fatigue syndrome, stress, vegetative-vascular dystonia, encephalopathy, degenerative disc disease, neuritis, polyneuritis, peripheral paralysis, sciatica, lumbago, sciatica, neuralgia, spasms of central origin, myasthenia gravis, traumatic lesions of the CNS;
- hepatitis, liver cirrhosis, chronic pancreatitis, disorders of the gastrointestinal tract;
- chronic circulatory failure, myocarditis, myocardial dystrophy , The recovery period after undergoing cardiovascular disease;
- Diabetes and its complications, diseases of the thyroid gland;
- neurodermatitis, eczema, acne, dermatitis various origins, herpes zoster;
- circulatory disorders of the retina, myopia, astigmatism, amblyopia, glaucoma, diabetic retinopathy, macular degeneration, neuritis optic nerve, cataracts;
- menstrual disorders, breast, conservative therapy uterine fibroids, salpingoophoritis, endometritis ;
- reduced immunity , Acute infectious diseases;
- neuritis of the auditory nerve, sensorineural hearing loss, labirintopatii;
- during antibiotic therapy Suppressing gram-negative gut flora;
- chronic diseases in the elderly, with alcohol or tobacco.
Contraindications
It should refrain from the use of Neurobeks when Neo:
- acute thromboembolism;
- polycythemia and eritremii;
- children's age less than 12 years;
- high sensitivity to its components.
Side effects
When treating Neurobeks Neo may develop nausea, tachycardia, itching and urticaria.
Instructions on Neurobeks Neo (The method and dosage)
As the instructions for use Neurobeks Neo daily administered one capsule. During the treatment of neurological disorders, the dosage can be doubled. The therapeutic course of 2-4 weeks.
Overdose
In cases of overdose, patients feel nervous excitement, pain in the heart, the development of tachycardia.
This is the treatment of gastric lavage, reception Activated Carbon , The use of other symptomatic treatment. The antidote is vitamin B6 isoniazid.
Cooperation
Concomitant use with Neo Neurobeks levodopa It can lead to a lowering of its antiparkinsonian efficacy.
Prolonged treatment anticonvulsants - phenobarbital, phenytoin m and carbamazepine in combination with Neo Neurobeks often arises thiamine deficiency .
The combination of this drug with colchicine or biguanidami reduces absorption cyanocobalamin.
Terms of sale
The drug is sold without a prescription.
Storage conditions
To store the capsules must be a dark, dry place inaccessible to children, with temperatures up to 30 ° C.
Shelf life
3 years.
Analogs
The main counterparts are presented drugs: Neurobeks, Neurobeks Forte Milgamma, Citoflavin, Aevi t and Neyrorubin .
Alcohol
The combined use of Neurobeks Neo and ethanol can dramatically reduce the absorption thiamine To the level in the blood of 30%.
Reviews on Neo Neurobeks
As is known, vitamins and vitamin complexes are an important part in maintaining the health of the organism. Therefore, these products are very popular in the society. At the same time reviews of Neo Neurobeks show that it is quite effective Vitamins. These capsules help to improve the overall condition of the body and recover quickly after suffering diseases.
However, experts warn patients that self-appoint themselves these funds should not be. Firstly, there is a certain number of contraindications to the reception of any vitamins, secondly, before trying to make up for the lack of any component, it is important to ascertain the need for this. For this reason intelligently select Vitamins can be only with a doctor based on laboratory data.
Price Neurobeks Neo where to buy
Price Neurobeks Neo in Minsk from 200 thousand. Rubles.
Buy in Moscow, the drug can cost 330-350 rubles.
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