Panangin

Description overdue on 06-06-2012

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The source of potassium and magnesium. The drug helps restore electrolyte balance Regulates the metabolism, metabolic reactions and processes, has a marked antiarrhythmic effect. Potassium is actively involved in synaptic transmission In the nerve impulses on fibers in the implementation of the muscle contractions, supports the normal functioning of the heart. When violations of exchange of potassium changes the excitability of muscle tissue and nerves. Due to the active ion transport is supported by a high potassium gradient across the plasma membrane. Small dosages of potassium promote expansion of the coronary arteries, and in large doses microcell narrows their lumen. Potassium has a moderate diuretic effects , Bathmotropic and hronotrovnoe negative impact. Magnesium is a cofactor three hundred sermentnyh reactions. Magnesium is an essential element for the processes and reactions that produce revenues and expenditure of energy. Magnesium is part of the pentose phosphate structure of DNA, is involved in the process of cell growth and division, structure of heredity, RNA synthesis; It is a natural BCCI, prevents the release of free fatty acids, catecholamines during stress, promotes penetration of potassium ions into the cell. The drug stimulates the synthesis of extracellular phosphate. Pananginum available in tablet form, as a solution.

Indications:

Panangin prescribed for hypomagnesemia, hypokalemia When taking laxatives and diuretics, corticosteroids, diarrhea, persistent vomiting, taking saluretics, myocardial infarction, Heart Failure , Digitalis intoxication, ventricular arrhythmia , Atrial arrhythmia, supraventricular tachycardia, paroxysmal tachycardia.

Contraindications:

Panangin does not apply in case of intolerance of fructose, sorbitol, impaired metabolism of amino acids in patients with chronic renal pathology system, hemolysis, exsicosis, dehydration, hypotension , Myasthenia gravis, atrioventricular block, hypermagnesemia, hyperkalemia, metabolic acidosis , Addison's disease. Panangin pregnancy used with caution.

Side effect:

Ulceration of the mucous wall of the digestive tract, epigastric pain, diarrhea, bleeding from the digestive system, drop in blood pressure, bradycardia, paradoxical reaction in the form of increasing the number of premature beats, dry mouth, nausea, flatulence, hyporeflexia, itching , Dyspnoea, thrombosis, phlebitis, paresthesia, dizziness, sweating, asthenia , Myasthenia gravis. With rapid intravenous infusion indicated gipermagniemiya, hyperkalemia.

Overdose:

Manifested muscle hypotonicity , Hyperkalemia, slowing atrioventricular conduction , Cardiac arrest, arrhythmia , Paresthesias of extremities, changes in the electrocardiogram. Requires emergency intravenous solution of dextrose, sodium chloride. If necessary justified peritoneal dialysis, hemodialysis.

Mode of application:

Panagin taken orally three times a day 2 tablets. Maintenance and preventive therapy: three times a day 1 tablet, in the course of 3-4 weeks. In some situations, you want to repeat the course of therapy. Panangina solution injected intravenously slowly. The drug is administered at a rate of 20-30 drops per minute 1-2 times daily 300ml. Dosing of the drug during pregnancy Panangin produced by the standard procedure of application of medication.

Drug Interactions:

Panagin can increase negative bathmotropic, dromotropic impact anti-arrhythmic drugs . The drug eliminates hypokalemia, which develops against the background of the prolonged use of diuretics, corticosteroids, ISS. NSAIDs, ACE inhibitors, heparin, potassium-sparing diuretics, cyclosporine, beta-blockers increase the risk of hyperkalemia. When using general anesthetics enhanced depressant effect on the nervous system panangina. Succinyl, decamethonium, atrakurony, suxamethonium increase neuromuscular blockade . Application enveloping and binding of drugs reduces the absorption of potassium and magnesium in the digestive tract. In combination with insulin, dextrose mixture composed polarizing normal heart rhythm with an overdose of cardiac glycosides, with ectopic arrhythmias, myocardial infarction. Panangin improves portability cardiac glycosides Pharmaceutically compatible with their solutions.