Flebodia 600

Description overdue on 04/07/2014

• Latin name: Flebodia 600
• ATC code: S05SA03
• Active substance: Diosmin (Diosmin)
• Manufacturer: Innothera Chouzy (France)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Flebodia 600 (Method and Dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Synonyms
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Granulated diosmin (basic active drug substance), which corresponds to the purified anhydrous - 600 mg.

Supporting components:

• talc;
• colloidal   silica ;
• stearic acid;
• microcrystalline cellulose ;
• a mixture of dyes - cochineal red (Ponceau 4R), titanium dioxide, propylene glycol , Red and black iron oxide;
• opaglos 6000   - Palm and beeswax, shellac, 95 percent ethanol.

The protective coating film is composed of:

• hypromellose ;
• microcrystalline cellulose;
• polyethylene glycol 400 stearate.

Product form

Biconvex round shaped tablet, coated pink sheath (protective film type Sepifilm 002 ). In the section look like gray-brown core with ambient light mantle. Packaged by 15 pieces in blister, carton, one or two blisters.

Pharmacological action

The main effects of the drug focused on venous bed:

• reduces the extensibility of veins;
• It tones the vascular wall;
• strengthens capillary walls, largely preventing the possibility of damage;
• to a certain degree eliminates the venous stasis ;
• increases resistance microvasculature ;
• It reduces the permeability of the venous capillaries.

Flebotoniziruyuschy effect   the active ingredient is dose-dependent Ie manifestations of the biological action is directly proportional to the amount of the medication.

Flebodia also influences the lymphatics   - Greatly increases the frequency of contraction of the capillaries, thereby increasing their functional capacity (increased lymphatic drainage ), Reduces the lymphatic pressure, enhances the density of the vascular bed.

The preparation improves blood circulation As promotes facilitated diffusion of oxygen and perfusion in the epidermal integument, stimulating way affects on the microcirculatory bed.

Separately, it is noted that Flebodia affects the nature of the biological active components:

• enhances vasoconstrictor effects adrenaline . noradrenaline ;
• prevents release free radical elements . prostaglandins and thromboxanes ;
• reduces adhesion leukocytes   the walls of the venous;
• reduces the number of free superoxide anions ;
• reduces the redistributive migration white blood cell   in paravenoznye tissue.

Pharmacodynamics and pharmacokinetics

Tablets Flebodia quickly adsorbed from the gastrointestinal tract (accepted orally ). It detected in plasma after two hours, and the maximum drug concentration in the blood observed after five hours after use of the drug.

Diosmin uniformly deposited as a hollow veins and in underfoot bloodstream lower limbs or in other tissues. The active components are derived mainly by the kidneys (approximately 80 percent unit dosage), to a lesser extent in the faeces (about 11 percent) and bile (2.4 percent).

Indications

• chronic venous insufficiency ;
• varicose saphenous veins of the lower extremities ;
• feeling heaviness in the legs , Especially at night;
• the initial stage of development Hemorrhoids   or hemorrhoidal crisis ;
• Prevention and treatment failure lymphatic channel ;
• a burning sensation in the lower extremities   in a horizontal position;
• microcirculatory disorders;
• increased capillary fragility .

Contraindications

• intolerance, hereditary idiosyncrasy or individual hypersensitivity to the constituent components of the drug;
• period Lactation and breastfeeding for new mothers;
• age group under 18 years.

Side effects

Medicine Flebodia usually well tolerated, providing maximum therapeutic effect without side effects. However, in clinical practice, some skilled described undesirable reactions such as:

• dyspepsia   (nausea, vomiting, pain in the upper abdomen, halitosis);
• headache or dizziness ;
• allergic reactions   (rash, itching . angioedema   and so on).

These side effects do not require treatment and are on their own after a short break in the conservative therapy.

Instructions for use Flebodia 600 (Method and Dosage)

Tablets used orally Regardless of food intake, physical activity and periods of wakefulness. Regimens prescribed individually by the attending physician or a qualified pharmacist, however, it usually takes one of the three most tested techniques.

If the drug is used to treat Varicose Veins   or Chronic venous insufficiency   lower limbs, the daily dosage of the drug is 1 pill a day. The course depends on the pathophysiological stages of the disease: the initial stages of development require taking the drug for two months, and later - three or four months. In the presence of trophic skin changes ( necrotic ulcers As an extreme degree of pathology) to prolong the course of six months. Repeat treatment may be every two to three months.

Instructions on Flebodia at 600 exacerbation of hemorrhoidal inflammation venous cavities of the rectum is much easier to remember. Appointed 2-3 tablets per day during the week for the relief of acute condition. Further, if necessary, the rate of prolong one tablet a day for two to three months.

During the second and third trimester of pregnancy, the drug helps to get rid of lymphovenous chronic failure If you take 1 tablet once a day. It is recommended to undergo therapeutic course under the supervision of qualified professionals, that is, when hospital treatment . Quitting sanitation should be two to three weeks before the birth of what should inform the physician.

Overdose

Symptoms of increased concentrations of drug in blood plasma are not registered.

Cooperation

No significant effects described in the combined use of drugs with pills Flebodia.

Terms of sale

The drug is in the free market, that is released in the pharmacy without a prescription form.

Storage conditions

Tablets should be stored in a dry place out of reach of children under age category, at room temperature to 27 degrees Celsius. Do not leave the drug is exposed to direct or reflected sunlight.

Shelf life

2 years.

Cautions

In therapy acute hemorrhoidal crisis It should be observed at the proctologist and hold regular additional studies, as the drug can exert its pharmaceutical effect immediately, which is fraught with deterioration and progression of the pathological process up to the loss of venous cavities of inflamed colon. In the absence of rapid effect therapy complemented by specialized drugs hemodynamic   and tonic .

Synonyms

Detraleks . Diosmin .

Analogs Flebodia 600

Angio protectors   - A large group of pharmacological drugs, the effect of which is directed at strengthening the walls of the macro- and microvasculature, prevent venous stasis and vascular insufficiency , Pathophysiological effects on the lymphatic vessels and biologically active substances Governing these indicators.

Thus, in addition to tablets Flebodia widely used drugs such as Vazoket, Diosmin, Diovenor . The spectrum of use in many ways similar to Flebodia, but the price can vary greatly analogues. For example, Vazoket is almost twice the territory of the Russian Federation, due to the pharmacokinetic characteristics of the drug.

Of special note is the drug as Detraleks   from the group venotonic drugs based Diosmin . In the Pharmaceutical Forum users often argue that it is better or Detraleks Flebodia 600, as indications, pharmaceutical and therapeutic course of action is receiving virtually no different. The secret lies in the unique technology of production processing of the main active ingredient in the tablets Detraleks. Micronization provides more rapid and complete absorption of the drug from the gastrointestinal tract, thus, the maximum plasma concentration observed after three or four hours after oral administration. Also Detraleks passes more a long period of biotransformation   with the formation of phenolic acids, due to which its half-life of just over eleven hours.

Flebodia during pregnancy

Medicament participated in the clinical studies teratogenicity , Where he showed a negative result, that is, the harmful effects to the developing fetus and the future mother of the body have been identified. However, in order to avoid adverse events or accidental involution treatment is prescribed only after the twelfth week When the initial shoots of vital tissues and organs have already been laid.

Reviews on 600 Flebodia pregnancy from patients confirmed positive effect   conservative treatment. Discomfort associated with the stagnation in the venous line, reduced to a great extent, which contributes to more easily during periods of pregnancy. Also happy moms celebrated improve the blood circulation of the skin , Covers look more healthy and natural traveled after treatment.

Reviews Flebodia 600

Reviews Flebodia at hemorrhoids   confirm the excellent pharmacological action of the drug. Pathophysiological effects of drug allows for a relatively short time conservative way to treat inflammation of hemorrhoidal cavities even in the most advanced stages. Also, it allows the tablet to mitigate the impact of acute crises that have a positive impact on the overall condition of the body.

Expectant mothers who undergo therapy lymphovenous failure   chronic type of pregnancy, and are completely satisfied with the drug. Flebodia gets rid of unpleasant sensations, inevitably accompanied by venous congestion, which greatly facilitates the physiological childbearing. Separately, it should be noted that due to the greater blood supply to the skin and venous effect Flebodia has a cosmetic effect on a woman's body.

Reviews physicians use in their clinical drug Flebodia characterize drug with a good side, because the pharmaceutical effect is exerted relatively quickly. Among similar angioprotectors pills in second place on this parameter. Also, the development of a rare side or adverse reactions, which are also held without a special medical intervention, give a hundred points to any other form Means for venous general therapeutic action.

Price Flebodia 600, where to buy

Price Flebodia 600 on the territory of the Russian Federation is 400-700 rubles for a small package (one loop blister - 15 tablets ). Medicine, calculated over a longer course of therapy ( 30 tablets   in a double blister) can be bought for 800-870 rubles.

In Ukraine, such tablets of hemorrhoids can buy more expensive. Thus, for example, range Phlebodia (30 tablets)   worth nearly 300 hryvnia, and the small - 160-190 hryvnia.

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