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Antiparkinsonian . The main components: Levodopa   (a precursor of dopamine) carbidopa   (an inhibitor of aromatic amino acid decarboxylase). Antiparkinsonian effects of levodopa is based on the conversion of the basic substance in the central nervous system dopamine that helps compensate the shortage Dopamine   in the nervous system. Lac eliminates tremor, rigidity, drooling, hypokinesia, dysphagia . Dopamine is formed in the peripheral tissues, does not participate in the implementation of the antiparkinsonian effects of levodopa, it responds to the severity of side effects of the drug. Carbidopa is an inhibitor of peripherally located dopa decarboxylase. Carbidopa reduces the production of dopamine in peripheral tissues, which increases the number of levodopa, which enters the central nervous system. The optimum combination of levodopa and carbidopa are considered to be 4: 1, 10: 1. Lac takes effect the next day, the full therapeutic effect is achieved during the week. Nak is available in tablet form.

Indications:

Lac prescribed for Parkinson's syndrome, Parkinson's disease, Parkinson's syndrome, caused by intoxication by toxic substances, methane, carbon monoxide, in the background cerebrovascular diseases .

Contraindications:

Nak does not apply to psychoneurosis , Severe psychosis, with angle-closure glaucoma, intolerance to levodopa, carbidopa, breastfeeding, skin diseases of unknown etiology, with melanoma , Pregnancy. In the pathology of pulmonary system, with erosive and ulcerative lesions of the gastrointestinal tract, seizures , Asthma, myocardial infarction with cardiac arrhythmias, with severe liver disease, renal system, with decompensated forms of endocrine diseases,   diabetes , CHF lac used with caution.

Side effect:

At the beginning of therapy possible dyspepsia , Nausea, vomiting, epigastric pain, ulcerogenic effects , Dysphagia. Rarely observed orthostatic hypotension , Arrhythmias. Against the background of long-term treatment are marked   hyperkinesis , Spontaneous movements, dyskinesia. Rarely recorded depression, irritability, insomnia, mental disorders, thrombocytopenia, hemolytic anemia , Leukopenia, constipation . tachycardia Weight gain.

Mode of application:

Lac take 2-3 times a day ¼ of a tablet inside. Gradually increase the dose every 3 days by ¼ tablet until the optimum effect. The average therapeutic dosage of 1-2 tablets per day. It is unacceptable to take more than 1, 5 g of levodopa, carbidopa 150 mg, corresponding to 6 tablets.

Special instructions:

Unacceptable abrupt withdrawal of the drug from the lac of the risk of symptom, which is similar to the malignant neuroleptic syndrome: increased levels of creatine kinase in the blood serum, the deviation in the psyche, increased body temperature, muscle rigidity . For patients who take antipsychotic medication or discontinued treatment dramatically, requiring a special monitoring. The drug is not applicable for the elimination extrapyramidal reactions Associated with taking medication. NAC therapy requires monitoring of peripheral blood evaluation of mental health patients. When eating a high-protein may be impaired Absorption   medicament. Patients with glaucoma need to control intraocular pressure. The tablets should be taken with food, drink water, if necessary, do not chew. Long-term treatment is required evaluation of the cardiovascular system, the kidneys, the blood, the liver. Lac take the scheme to the proposed transaction, as well as immediately after. The drug affects the management of vehicles, reduces the speed of psychomotor reactions.

Drug Interactions:

Irregular heartbeat occurs while the application ditilina, beta-agonists , Medicines for inhalation anesthesia. Tricyclic antidepressants   one reduces the bioavailability of the active ingredients - levodopa. Klozepin, diazepam, Mr. holinoblokatory, clonidine , Phenytoin, neuroleptics , Thioxanthene, difenilbutilpiperidin, phenothiazines, reserpine, papaverine, pyridoxine reduce the severity of antiparkinsonian effect of the drug. Hallucinations and dyskinesia   observed when prescribing lithium. Methyldopa aggravates side effects. MAO inhibitors lead to poor circulation, which is associated with the accumulation of norepinephrine   under the influence of dopamine and L-dopa, increased blood pressure. At reception tubocurarine   a marked decrease in blood pressure.