Famotidine

Description overdue on 28.03.2012

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Histamine receptors. The active ingredient suppresses basal production of hydrochloric acid in the stomach and stimulate acetylcholine , Histamine and gastrin HCl. Famotidine reduces the activity of pepsin, increasing gastric pH and reduces the production of HCl. By improving the level of glycoproteins , Increased production of gastric mucus, stimulate the synthesis of prostaglandins , Bicarbonate secretion achieved a protective and wound-healing effect of the drug famotidine. The drug helps stop   gastric bleeding , Promotes healing of damage to the gastric mucosa, scars stress ulcers . The drug has little effect on oxidase enzyme system cytochrome P450 system in the liver (the vast influence). His action famotidine starts in an hour, it lasts 12-24 hours. When administered intravenously, the effect is registered over half an hour. A single dose leads to the suppression of secretion of 10-12 hours. Famotidine is available in tablet form, as a lyophilisate (solution administered intravenously).

Indications:

Famotidine prescribed for gastric hyperacidity , Ulcerative lesions of the digestive system, stress ulcers, symptomatic ulcers, Zollinger-Ellison syndrome , NSAID-gastropathy, erosive reflux esophagitis embodiment, heartburn , To prevent a recurrence of bleeding after surgery on the digestive system, multiple endocrine adenomatosis, when the system mastocytosis . Famotidine is indicated for the prevention of aspiration of gastric juice in patients who are given general anesthesia. The drug is effective in dyspepsia. The drug is indicated for the prevention of aspiration pneumonitis .

Contraindications:

Famotidine is not indicated during breastfeeding, hypersensitive to any ingredient in the gestation period of the pregnancy. In cirrhosis of the liver with concomitant portosystemic encephalopathy, with renal disease, hepatic system in pediatrics prescribed with caution.

Side effect:

The digestive tract:   epigastric pain, dry mouth, nausea, decreased appetite, vomiting, increased liver enzymes, acute pancreatitis Mixed hepatitis, hepatocellular hepatitis, cholestatic hepatitis. Senses:   ringing in the ears, paresis of accommodation , Blurred vision. Genito-urinary system : Decreased libido, amenorrhea , Gynecomastia, hyperprolactinemia . It may develop agranulocytosis, allergic reactions, tremor, drop in blood pressure, dizziness, asystole, AV block, bradycardia, anaphylactic shock , Bronchospasm, myalgia, arthralgia, hallucinations.

Overdose:

Manifested by tremor, collapse, motor excitation, drop in blood pressure, vomiting. Requiring hemodialysis, posimptomnaya therapy.

Mode of application:

Famotidine tablets taken orally. In ulcerative lesions of the digestive system: at 0, 02 grams twice a day, either 0, 04 grams before bedtime. In some cases, the amount of the drug is increased to 80-160 mg. Duration of treatment 4-8 weeks. In order to prevent a recurrence of ulcers appoint 1 times a day for 0, 02 g per night. The initial dose of Zollinger-Ellison syndrome - 20-40mg 4 times a day, may increase the dose to 24-48 mg. Prevention of aspiration of gastric contents: 0, 04 grams; before surgery taking 2 hours before surgery. When reflux esophagitis: twice a day for 0, 02 grams. Famotidine intravenously injected slowly for 2 minutes: 20 mg every 12 hours. For the prevention of aspiration pneumonitis: 0 intramuscularly, 02 grams before surgery, or the morning of the surgery. Powder for injection of sodium chloride dissolved in 0, 9% 5-10 ml.

Special instructions:

Admission famotidine may mask symptoms suggestive of carcinoma   in the stomach. It is recommended that before prescribing the drug to eliminate malignant tumors of the digestive tract. The drug must be withdrawn gradually to prevent the syndrome of "rebound". Under stress, long-term therapy may develop a bacterial infection in the stomach, it is possible to further the spread of germs. Famotidine should be taken two hours after application ketoconazole . itraconazole   for the prevention of gipervsasyvaniya. During the skin reactions to histamine is important to consider that the histamine receptor blocker may suppress reactions and lead to false-negative results. Treatment involves the exclusion from the diet foods that irritate the stomach lining.

Drug Interactions:

Famotidine inhibits the metabolism of diazepam, aminophenazone, phenazone, lidocaine, caffeine, tricyclic antidepressants , Phenytoin, indirect anticoagulants, aminophylline, metronidazole, metoprolol , Buformin, glipizide, theophylline, metoprolol,   clavulanic acid   in the liver. When you receive drugs which depress Bone marrow   increases the risk of neutropenia. Famotidine reduces the absorption of ketoconazole, itraconazole. Sucralfate, antacids, and slow the rate of absorption. Famotidine compatible with sodium chloride, dextrose. The drug increases the absorption of clavulanic acid, amoxicillin.