Description overdue on 10/23/2014
- Latin name: Dramina
- ATC code: R06AX
- Active substance: Dimenhydrinate (Dimenhydrinate)
- Manufacturer: JSC "Jadran", Croatia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- During pregnancy (and lactation)
- Side effects
- Instructions for use Dramina (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
Each tablet contains the active ingredient Dramina: dimenhydrinate - 50mg.
Additional ingredients: magnesium stearate, lactose monohydrate, MCC, povidone, and crospovidone.
Product form
Dramina produced in the form of 50 mg tablets packed in a pack 5 or 10 pieces.
Pharmacological action
Tablets have sedative, antiemetic, antihistamine and antiallergic action.
Pharmacodynamics and pharmacokinetics
For this product is characterized by blockage of the central H1 gistavminovyh receptors and m-cholinergic antagonists. Furthermore, block the synthesis of acetylcholine, acetylcholine production decreases at the presynaptic terminal, reduces release of a substance into the synaptic cleft. Also noted oppression vestibular stimulation by summing antihistamine and m-anticholinergic effect.
High dosages of drugs can affect the semicircular canals in the middle ear, corresponding to equilibrium for the support and orientation in space. Dramina positive effect on the vestibular system, eliminating the dizziness , Nausea and vomiting which cause various vestibular disorders, for example, kinetosis .
Tablets have sedative , Moderate antiallergenic and weakly expressed mestnoanesteziruyuschee effect. Getting inside the body, the drug is rapidly and fully absorbed from the gastrointestinal tract. Manifestation protivorvotnogo observed after 15-30 minutes after taking the drug and lasts an average of 3-6 hours. Regarding the distribution of the substance, it occurs in the body tissues, with a slight binding to plasma proteins. High concentrations Dramina can penetrate the blood-brain or blood-placenta barrier. Metabolism and elimination occurs during the day, a small part of the substance can be released in breast milk.
Prolonged use of the drug sometimes causes tolerance dimenhydrinate , Thereby reducing the severity of antiemetic and sedative effect, but completely preserving antihistamine effect.
Indications
The drug is intended for:
- prevention and treatment of kinetoses, sea and air sickness, symptoms of vestibular disorders and hyperstimulation maze , eg, dizziness, nausea, vomiting and so on;
- treatment of vestibular disorders associated with brain injuries;
- treatment Meniere's disease.
Contraindications
Do not take Dramina at:
- individual hypersensitivity to its components;
- epilepsy;
- seizures;
- acute exudative and vesicular dermatosis ;
- patients aged up to one year;
- lactation pregnancy.
Should be considered particularly during the treatment of patients with angle-closure glaucoma, asthma, prostatic hyperplasia, cardiovascular disorders, hyperthyroidism, ulcerative diseases of the gastrointestinal tract and so on.
Dramina during pregnancy
During Lactation and pregnancy taking the drug is not recommended.
If it becomes necessary to assign tablets lactation period, then the treatment is stopped breastfeeding. At the same time, you can resume the feeding of the baby after 5-7 days from the date of receiving the last of the drug.
Side effects
In the treatment of pills Dramina may occur in disorders of the central nervous system, for example: general weakness, fatigue, decreased reaction rate, impaired concentration, development of headache, dizziness, nervousness, anxiety, sleep problems or wakefulness and other.
Also, deviations in the activities of the digestive, respiratory, cardiovascular, development allergic reactions and other undesirable symptoms.
In some cases, reduce or eliminate the side effects of the action can be by discontinuation of treatment or reducing therapeutic dosages . All cases of side symptoms it is recommended to discuss with your doctor.
Instructions for use Dramina (method and dosage)
As you know, the tablet Dramina instructions for use advises taken orally before eating a meal. They are used in the treatment of sea and airsickness , During the prevention and treatment of vestibular and labyrinth disorders such as dizziness, nausea or vomiting, except for deviations which are caused by anticancer therapy.
Dramina for children 3-6 years old is appointed as a half or a quarter of the tablet to the reception a day 2-3 times. Children 7-12 years appoint half or the whole tablet per day for 2-3 times. For children from 12 years and adult patients may appoint a day for 1-2 pieces 2-3.
Treatment Meniere's disease children under 12 years requires the appointment of a daily dose of one tablet or half of the 2-3 times, patients from 12 years of fashion to take 1-2 tablets 2-3 times.
The maximum daily dosage for adults should not be more than 7 tablets.
In carrying out prevention kinetoses it is recommended to take the medicine for half an hour before the trip for 1-2 pieces.
Duration of drug therapy and repetition rate should be carried out in consultation with a specialist.
Overdose
In cases of overdose, you may experience dryness mucosas the mouth and throat, breathing problems, confusion, development and convulsive status hallucinations .
Development overdose symptoms requires medical care with gastric lavage, purpose saline laxatives, symptomatic therapy.
Cooperation
Dramina able to enhance the effect of Mr. holinoblokatorov , eg, atropine , and tricyclic antidepressants, barbiturates, catecholamines, neuroleptics, hypnotics and sedatives means. Concomitant use with drugs that depress the central nervous system, increases efficiency Dramina. It is also noted a decrease in depressive action acetylcholine in cardiac muscle. Combination therapy with bismuth drugs, psychotropic and anesthetics resources . scopolamine increases the risk of rejection of visual function. In addition, it sets the incompatibility with Dramina ototoxic antibiotics , eg, streptomycin, amikacin, neomycin viomycin and kanamycin . It is possible to disguise the symptoms of ototoxicity of these funds, the development of hearing loss that interferes with timely diagnosis.
Terms of sale
Dramina available without prescription.
Storage conditions
For storage of the drug is intended to place at a temperature of 25 C, reliably protected from children.
Shelf life
5 years.
Analogs
Lordestin
Lomilan
Fenkarol
Kestin
Loratek
Aerius Feksadin
Claritin
Telfast
Loratadine
Diazolin
By analogues of this drug include: Motilium, Reglan, Domperidone, Metoclopramide and others.
Alcohol
Simultaneous use of Dramina and alcohol can significantly enhance its effect.
Reviews Dramina
As numerous reviews about the preparation, all those who took it in a particular case, he noted high-performance . Often, users are discussing on the network from which the pills are helping Dramina best and whether it causes drowsiness.
Some patients report that the effect of this agent is shown just after half an hour, and at about the same time, they feel a strong drowsiness. However, others notice the positive effect, but the side effects including drowsiness, not felt. Therefore, one can understand that the sedative effect is dependent on the characteristics of the nervous system of the individual.
Furthermore, active drug discussed topic effect on small children. Thus, when the tablets are used in aircraft, opinions about Dramina reported that patients better tolerate flights. For this reason, if a child has a tendency to complications of health while traveling, you need to choose a pediatrician with the appropriate medication that will help make the trip more pleasant.
Price Dramina where to buy
Price Dramina in tablets of 50 mg, 5-10 pieces of 73-180 rubles.
No comments:
Post a Comment