Description overdue on 12/18/2014
- Latin name: Apap
- ATC code: N02BE01
- Active substance: Acetaminophen (Paracetamol)
- Manufacturer: Ltd. JUS Pharmacy, Poland
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (way to and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One tablet formulation contains 500 mg Apap paracetamol . starch, croscarmellose sodium, stearic acid, wax, povidone, polyethylene glycol, hydroxyethylcellulose .
Product form
The drug release in the form of white oblong tablet soluble shell, on the one hand the inscription "APAP". The tablets are packaged in contour package of 6 or 12 pieces, 6, 12 or 24 pieces in a carton box. Also agent sold in plastic jars of 50 tablets each.
Pharmacological action
The analgesic, antipyretic, anti-inflammatory .
Pharmacodynamics and pharmacokinetics
Paracetamol belong to the group analgesics, antipyretics . The substance has a bland anti-inflammatory effect.
The mechanism of action is due to inhibition of the means of synthesis prostaglandin in the central nervous system. Apap - a powerful inhibitor enzyme cyclooxygenase arachidonic acid It increases the sensitivity to the effects of specific receptors Serotonin and kinin , Thus, boosting pain threshold.
The brain hypothalamus there is a center that is responsible for the body's thermoregulation. The active substance reduces the concentration of the drug prostaglandins in the center - the body temperature is lowered.
Paracetamol does not have the properties to lower prothrombin index or in some way or to influence the process of blood clotting.
After penetration GI drug almost immediately and rapidly absorbed and enters the systemic circulation. Its maximum concentration is reached within an hour, and about half of the substance contact with plasma proteins.
Analgesic effect lasts no more than six hours, antipyretic - no more than eight. Metabolic reactions occurring in the liver derived metabolites via the kidneys. Particular attention should be paid to the metabolite N-acetyl-p-benzoquinoneimine Which is active. It is believed that this metabolite and has a toxic effect on the liver.
Persons suffering from liver or kidney disease, taking paracetamol not recommended.
Indications
The drug is prescribed for the relief of pain, reduction of body temperature Flu or colds , and:
- at headache ;
- toothache ;
- neuralgia and muscle pain;
- at dysmenorrhea .
Contraindications
The drug is contraindicated:
- at allergies at any of its components;
- when expressed renal failure ;
- alcoholics ;
- in case of serious liver disease;
- lactating women.
Side effects
During treatment with Apap may occur:
- hypoglycemia ;
- allergic reactions (rash, hives . erythema . Lyell's syndrome . angioedema );
- drowsiness and confusion, impaired concentration, weakness, dizziness;
- nausea, abdominal pain, increased liver enzymes . gepatonekroz ;
- cyanosis . anemia Pain in the heart, hemolytic anemia . agranulocytosis . leukopenia . thrombocytopenia . aplastic anemia ;
- renal colic . nephritis . papillary necrosis ;
- palpitations, tachycardia , Increasing Blood Pressure .
Instructions for use (method and dosage)
For adults and children over 12 years is a maximum daily dosage of 8 tablets. Recommended dosage - 1 or 2 tablets every 4 or 6 hours.
For children from 6 years of age it is recommended to take no more than 500 mg of acetaminophen at a time.
Apap It should not take longer than 10 days.
Overdose
The main symptoms of overdose are nausea, stomach pain and vomiting. When very large doses may cause: thrombocytopenia , Kidney failure, liver failure, agranulocytosis , Severe intoxication.
If the overdose took less than an hour, it is advisable to wash out the stomach, producing symptomatic treatment, maintaining vital functions affected, follow the breath and content electrolytes in blood.
It is recommended as soon as possible to administer intravenously 150 mg per kg patient body weight acetylcysteine (5% glucose, for 15 minutes); 50 mg per kg weight - 4 chasa; 100 mg per kg weight - 16 hours. And then administered a maintenance dose orally every 4 hours. Consideration should be given blood counts and, if necessary hemodialysis .
Cooperation
Apap not be combined with antacids Because they can reduce the efficacy of the drug.
Anticonvulsants such as barbiturates . carbamazepine . phenytoin . isoniazid . stimulating activity microsomal enzymes liver, will enhance the toxic effect on the body.
The drug is not recommended to combine with alcohol, paroxetine . sertraline . citalopram . fluoxetine Orally GCS . antiplatelet . anticoagulants .
Activated carbon and others enterosobrenty reduce the effectiveness of funds.
Terms of sale
To acquire funds require a prescription.
Storage conditions
Keep the medication in a cool place, in original packaging, away from children.
Shelf life
3 years.
Cautions
Precautions should be a means for older people.
With prolonged use, you need to monitor the performance of the patient's blood and the level liver enzymes .
Analogs
Sedalgin Neo
Rinzasip
Kaffetin Light
Kaffetin
Rinikold
Koldakt Flew Plus
Rinzai
Tsefekon
Antigrippin
Tylenol
Coldrex
Theraflu
Flyukold
Farmatsitron
Solpadein
Paracetamol
Fervex
Efferalgan
Panadol
Antigrippin, Paracetamol, Aksagripp, Antiflu, Apap C Plus, Vokasept, Gripgo, Panadol, GrippFlyu, Rinzai, Solpadein, Flyukold, Yunispaz , Tsefekon, Rinikold.
During pregnancy and lactation
Apap has not embryotoxic . teratogenic or mutagenic influence on the organism. Paracetamol is able to penetrate through placenta such and recognisably separate with thoracal milk.
The medicine is prescribed when absolutely necessary, when the intended benefits to the mother outweighs the potential risk to the child.
Reviews
Reviews of Apapa bit. Of those that are - they are all good. In mainly, the drug often prescribe from the migraine headaches , Dental pain, and for the relief of any other pain. Unlike cheaper analogues of the drug adverse reactions occur much less frequently.
Cost
Specify the actual cost of the drug Apap currently impossible.
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