Description overdue on 10/14/2014
- Latin name: Viferon
- ATC code: L03AB01
- Active substance: Human recombinant α - 2b interferon (Interferonum alpha-2b, IFN-α2b).
- Manufacturer: Ltd. "Feron", Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Viferon: what candles, ointment and gel
- Contraindications
- Side effects
- Instructions for use Viferon
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Viferon for the children
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One gram ointment Viferon for local and external use contains 40000ME Interferonum alpha-2b as active ingredient and 0 002 grams alpha-tocopherol acetate (alfa-Tocopherol acetate) and a number of other auxiliary ingredients.
In one rectal suppositories Viferon 1 It contains 150,000 IU Interferonum alpha-2b as an active ingredient, 0 055 g alpha-tocopherol acetate (alfa-Tocopherol acetate), 0, 015 g ascorbic acid (Acidum ascorbinicum) and a number of of other subsidiary ingredients.
In one rectal suppositories Viferon-2 It contains 500,000 IU Interferonum alpha-2b as an active component, 0, 055 g of alpha-tocopherol acetate (alfa-Tocopherol acetate), 0, 022 g ascorbic acid (Acidum ascorbinicum) and a number of other auxiliary ingredients.
In one rectal suppositories Viferon 3 contained 1000000 IU Interferonum alpha-2b as the active component, 0, 055 grams of alpha-tocopherol acetate (alfa-Tocopherol acetate), 0 022 g ascorbic acid (Acidum ascorbinicum) and a number of other auxiliary ingredients.
Part candles Viferon-4 enter 3000000 IU Interferonum alpha-2b as an active ingredient, 0 055 g alpha-tocopherol acetate (alfa-Tocopherol acetate), 0, 022 g ascorbic acid (Acidum ascorbinicum) and a number of other auxiliary ingredients.
In one gram of gel Viferon for local and external use contains 36000ME Interferonum alpha-2b as active ingredient and 0 055 grams of alpha-tocopherol acetate (alfa-Tocopherol acetate) and a number of other auxiliary ingredients.
Product form
The drug has three dosage forms:
- candles Viferon 150 thousand. 500 thousand., 1 million and 3 million IU;
- ointment;
- gel.
Viferon gel - a homogeneous substance opaque grayish-white color.
An ointment is a viscous homogeneous mass with a characteristic odor of lanolin. Color ointment can range from yellowish-white to yellow.
Suppositories are Viferon bullet shape, their consistency is uniform, and the color is white with a yellowish tinge. Allowed discontinuity in the cut. There may be a recess in the form of a funnel.
Pharmacological action
The drug has a pronounced antiviral . antiproliferative and immunomduliruyuschee action.
The combination IFN-α2b with antioxidants increases Antiviral Activity active drug substance, its regulating effect on immune system and, in particular, on T and B cells (of developing pretimotsitov in the thymus lymphocytes ), Normalizes the concentration in the body immunoglobulin E .
Due to a similar combination of components also manages to exclude probability of development of in a patient of adverse reactions, which arise when administered of preparations of interferon parenterally, and to normalize the functioning of endogenous (inner) of the system of interferon.
Application Viferon for treatment and prevention viral infections It allows several times to reduce the dose prescribed to the patient hormones and antibiotics (in some cases even avoids prescribing these drugs).
In addition, use of the drug can reduce the severity of the toxic effects antibacterial or hormone replacement therapy .
Extrasmall important it is and the fact that neutralizing antibody to inbound in composition of the drug IFN-α2b y patient not to formed even at long application Viferon.
Pharmacodynamics and pharmacokinetics
Alpha-interferon is a member of the group water-soluble proteins . Its mechanism of action includes:
- direct antiviral activity (it is effective against Virus . causing influenza, herpes, hepatitis etc.);
- antibacterial (bacteriostatic) effect against infections of mixed type;
- restoration of function of endogenous (internal) system interferon;
- stimulating factors enhance the production of antibodies ;
- Increasing the body's resistance to various infections.
Antibacterial activity of the substance determined by its ability to increase cytotoxic activity of lymphocyte cells and encourage phagocytic activity of macrophages .
The antiproliferative effect IFN-α2b has at involving both cell cultures and human xenograft tumors and laboratory animals.
IFN-α2b suppresses the replication of virus genome . By binding to specific receptors on cell membranes Alpha-interferon triggers specific sequence of complex reactions within the cell, including the induction of some enzymes .
Develop on the background of Viferon membrane-stabilizing . regenerating and anti-inflammatory effects due to the activity of members of the drug substances with powerful antioxidant action - alpha-tocopherol acetate and ascorbic acid .
After parenteral administration of the drug concentration ratio interferon alpha plasma patient reaches maximum values for 3-12 hours.
When using IFN-α2b vaginally or rectally substance absorbed through the slizistu0yu shell It penetrates into the adjacent tissue and lymphatic system , Thus exerting a systemic effect. And thanks in part to its ability to be fixed mucosal cells IFN-α2b acts locally.
Using rectal suppositories Viferon increases the circulation of interferon circulatory system (when administered preparations IFN-α2b into a muscle or into a vein this pharmacokinetic indicator essentially less).
The level of serum interferon is reduced by approximately through the twelve hours after reception Viferon, that the assumes necessity of its re-introducing.
Report from the body interferon alpha mainly by means of Renal catabolism . Metabolism in the liver and biliary excretion - Less important elimination pathway. Part of the interferon alpha is eliminated through kidneys unchanged.
The substance is not cumulated (not stored) in the different tissues.
Indications Viferon: what candles, ointment and gel
Indications for use of the gel and ointment
Gel is indicated for the treatment and prevention of children ARI (including a FIC) and relapsing false croup ( stenotic laringotraheobronhita ).
The ointment is recommended for the treatment of lesions of the skin and mucous membranes Provoked different viruses (in particular for the treatment of lesions induced activity papillomavirus human activity virions Belonging to the family herpesvirus ).
In combination with other therapeutic interventions in the form of an ointment preparation may be used for treatment respiratory diseases in children older than one year of age.
Indications for use of candles, which prescribe this dosage form
Viferon as suppositories administered as a component of complex therapy:
- for the treatment of children infectious diseases, inflammatory nature (a drug approved for use including neonates and premature infants, gestational age with more than 34 weeks).
- By proceeding in chronic viral hepatitis B, C and D in adults and children (usually a drug used in combination with plazmotsitoforezom ).
- By proceeding in chronic viral hepatitis Complicated cirrhosis of the liver .
- Pregnant women who have been diagnosed urogenital infections And in the presence of pregnant herpes infection of the skin and mucous membranes .
- With Flu . ARI and SARS in adults (including inter alia ARI, complicated by a bacterial infection ).
Before, how to apply Viferon, is required's consultation at the attending physician.
Contraindications
Viferon is contraindicated in patients with appointment hypersensitivity interferon alpha or any of the members of the drug excipients.
Side effects
The treatment with interferon in the form of rectal suppository, gel or ointment individual patients with hypersensitivity to its components can be side effects lead to a different kind of allergic reactions .
Side effects are reversible, does not require the appointment of a specific treatment and disappear on their own within 72 hours after discontinuation of the drug.
Instructions for use Viferon
Ointment Viferon: instructions for use
In the dosage form of the drug is used as a local and an external agent.
A small amount of the ointment distribute a thin layer to the affected areas of skin and mucous from three to four times a day, and then gently rubbed. The treatment normally lasts no longer than a week.
Gel Viferon: instructions for use
Gel suitable for topical application. Also, it may be used in combination with other drugs.
The gel is used for prophylaxis in children acute respiratory disease and of recurrent Krupa syndrome ( stenosing laryngitis ). When applying product to swab them three times a day for three months is treated tonsils child.
Courses should be repeated twice a year.
Using gel for infants as a preventive measure to reduce the likelihood of a child SARS This is especially important in times of epidemics. For this small amount of gel is applied to the pre-dried nasal mucosa .
For therapeutic purposes, tonsils treated with up to five times a day until the end of the acute phase of the disease. Further treatment involves the application of the drug three times a day for three weeks.
The gel is also used to treat adult patients chronic infection caused herpesvirus . Therapy with different localization of the pathological process is recommended to start as early as possible.
Optimally - until the disease is in a latent form (latent form for the clinical recognition) and makes itself felt episodic appearances precursors.
The lesion should be processed from four to seven times a day. Duration of treatment - from three to five days. If necessary, it can be assigned to a second course.
Candles Viferon: instructions for use
Rectal suppositories are used in conjunction with other designated a specific disease drugs in the form of tablets, powders or injections.
For adult patients with chronic viral hepatitis Usually administered Viferon-4 Dose of the active substance which is 3000000 IU. The treatment involves injecting one suppository twice a day for ten days.
Subsequently, they are sufficient administered three times a week. The treatment varies depending on the nature of the flow and the degree of disease severity, ranging from six months to a year.
With the defeat of the body urogenital infections And also in pregnant women with primary and recurrent herpes infection For the treatment recommended spark Viferon-2 with an active substance content of 500,000 IU.
Suppositories are administered on a single day twice. Course duration ranges from five to ten days. If necessary, repeat.
For the treatment of infections caused by herpesvirus Is shown Viferon 3 In which the dose of active substance was 1000000 IU. Candles are administered twice a day, keeping the intervals between administrations The noon.
Duration of the course - 10 days. In the case of recurrence of the duration of therapy is determined by the attending physician (the best is to begin treatment at the beginning of the manifestation of its symptoms).
As a preventive measure is recommended to repeat the treatment every four weeks.
For the treatment of acute respiratory infections and influenza for adults candles administered in a dosage of 500 thousand IU. They put one twice a day between injections maintaining regular intervals.
Instructions for use of candles for children
For the treatment of newborn and premature babies whose gestational age greater than 34 weeks in combination with specific therapy prescribed for a particular infectious disease, it is recommended to use suppositories Viferon 150,000 IU.
The course involves the introduction of throughout five days of one suppository twice in the day through equal intervals of time.
Preterm infants, gestational age less than 34 weeks, put on prescribed prtyazhenii five days on one suppository Viferon 150,000 IU three times a day.
Children, including newborns and premature babies, with Flu . SARS . pneumonia . meningitis . enterovirus infection patients spend one to two courses of treatment; for the treatment of an infection provoked herpes virus Usually requires two courses; at cytomegalovirus infection . infections caused by mycoplasma and Candida species And when sepsis necessary to carry out two or three courses.
Between courses stand five-day intervals.
Instructions on candles for infants are encouraged to nominate Viferon the following dosages:
- for infants up to six months - from 300 to 500 000 IU per day;
- infants from 6 to 12 months to 1 year - 500 000 IU per day.
Children over one year of age appoint 300 000 IU per 1 sq. m body surface area per day, and children over the age of seven - 500 IU.
The calculation of the optimal therapeutic dose infant is based on data on the severity and nature of the disease in children.
The daily dose should be divided into two stages, maintaining between them equal time intervals. During the first ten days of treatment involves daily administration of suppositories, then put the candle three times a week. Course duration ranges from six months to one year.
Children who have been diagnosed chronic form of hepatitis with a pronounced degree of activity and the presence of cirrhosis suppositories should be administered by one twice a day for two weeks before the procedure plazmotsitoforeza or hemosorption .
Children younger than the age of seven shows a dose 150 thousand IU, children over seven years - 500 thousand IU dosage.
How to put babies candles?
Before the introduction of the suppository baby lay on its side on the oilcloth, while pursing his legs to his stomach. It is best to put the candles after a bowel movement.
To facilitate the the introduction of children's candles Viferon can be cut in half and / or to drip at him a little bit of children's a cream or of vaseline oil.
Then you need to push the child's buttocks with your fingers, light a candle, and for some time to pinch the buttocks, while fixing a child.
Overdose
Cases of overdose have not been recorded.
Cooperation
Interactions in the dosage forms for the local and external application are not revealed.
Viferon in the form of rectal suppository blends well with all the drugs that are used to treat diseases described under "Indications."
The product is compatible with antibacterial and hormonal therapy . chemotherapy drugs As well as immunosuppressive .
Terms of sale
Viferon in the form of suppositories, gel and ointments dispensed in pharmacies without a prescription.
Storage conditions
The optimal temperature for storage of the drug - from 2 to 8 degrees Celsius. Keep the drug in all its pharmaceutical forms recommended in a dry, dark and inaccessible to children.
Shelf life
For rectal suppository - 24 months.
For gel and ointment - 12 months.
Cautions
Many people wonder whether there are injections, drops or tablets Viferon. The answer to this question in the negative.
This is explained by by the fact that protein molecules Getting into alimentary canal They are subject to the effects of its various secretory fluids and enzymes , And since, operating substance Viferon IFN-α2b is protein , These enzymes will have a similar effect on him.
Thus, reception of interferon alpha in the form of tablets will not give the expected therapeutic effect and is simply impractical.
With regard to injections, the Viferon / w is not input because of the interferon dosage form capable of provoking serious side reactions in various organs and systems.
Viferon developing the drug, experts of the company "Feron" the main task is to establish a safe treatment for viral infections in all groups of patients, including neonates (including premature) and pregnant women.
Therefore, look for pharmacies Viferon tablets or injections - a waste of time.
Often, patients have questions, "What is the difference Viferon and Viferon-2? "Or" What are the differences and Viferon Viferon-3? ".
Candles Viferon available in four versions, which are respectively called Viferon-1, 2, 3 and 4. They differ in the dose of their constituent IFN-α2b.
Viferon-1 is used for the treatment of children up to seven years prophylaxis of viral infections in pregnant women, Viferon-2 - for children over the age of seven and treating viral infections in pregnant Viferon-3 is used to treat adult patients, as well as Viral Hepatitis children, Viferon-4 prescribed only to adults.
The network can often find applications that Viferon as other interferon preparations, causes cancer . However, they do not have confirmation. It is known that the injectable forms of interferon provoke the development of a large number of adverse reactions. In contrast Viferon produced in the form of suppositories, ointment and gel, so it belongs to the interferon composition is absorbed into the skin and mucous membranes with very small amounts.
Analogs Viferon
Interferon
Nazoferon
Infagel
IFN-EU-Lipint
IFN-EU
IFN-Lipint
Altevir
Algeron
Genferon Light
Genferon
Grippferon
When prescribed by a doctor of a drug (especially if the drug is expensive, as, in particular, Viferon), most patients begin to look for things to replace this facility and find cheaper counterparts.
Analogs of candles Viferon - a drug Vitaferon . Genferon . Laferobion . Laferon . Prices of Ukrainian counterparts in pharmacies starting from 46 USD.
Frequent questions as "What is better - Kipferon or Viferon? ", "What's better - Grippferon or Viferon? "Or" Anaferon ".
from
Kipferon
and ).
pregnant
pregnant
pregnancy
.
viral infections
.
ARI . SARS and Flu .
papillomas .
antibiotics .
infection
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