Description overdue on 10/23/2014
- Latin name: Cortexin
- ATC code: N06BX
- Active substance: The polypeptides of the cerebral cortex of cattle
- Manufacturer: Ltd. "Geropharm", Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Babies
- Contraindications
- Side effects
- Injections Cortexin: instructions for use
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Cortexin children
- Reviews
- Price, where to buy
Composition
The composition contained in a single vial of lyophilized powder for injection includes 5 or 10 mg of a water-soluble polypeptide fractions (cortexin) as active ingredient and 6 or 12 mg of glycine as stabilizer.
Product form
The drug is available as a sterile lyophilized powder for solution for intramuscular administration.
Cardboard packaging is equipped with two blisters, each containing 5 vials of freeze-dried products and guidance on the application.
Pharmacies can buy Cortexin №10 10 mg and 5 mg Cortexin №10.
Cortexin 10 mg to 22 mg is released in 5 ml vials. It is for the treatment of adult patients.
Cortexin 5 mg is designed specifically for pediatric use. It is available in 11 g vials of 3 ml.
Pharmacological action
Cortexin belongs to a group nootropic and GABAergic drugs Acting primarily on CNS . Against the background of its application notes:
- nootropic ;
- neuroprotective ;
- Antioxidant ;
- tissue-specific effects.
Pharmacodynamics and pharmacokinetics
Cortexin - a bioregulator with polypeptide structure, which is a complex of water-soluble neuropeptides . The molecular weight of the polypeptide fractions not exceeding 10,000 Daltons, which allows them to penetrate the physiological barrier separating central nervous and circulatory system .
The mechanism of action of the drug is realized through:
- activation of the regulatory peptide neurons and brain-derived neurotrophic factor ;
- normalization of relations amino acids Performing mediator functions excitatory and inhibitory type of action, as well as important brain neurotransmitters dopamine and Serotonin ;
- moderately expressed GABA-ergic effects;
- reducing paroxysmal (paroxysmal) seizures brain and indicators of its ability to normalize bioelectric activity;
- prevent the formation of oxidative degradation lipids (free radicals).
Nootropic action Cortexin accompanied by improvement higher brain functions , Improved memory, increased learning ability and stress.
The neuroprotective effect is manifested in the ability of agents to improve the stability of the fabric of the brain to the damaging effects of various endogenous neurotoxic factors and reduce the toxic effects of neurotropic agents.
The antioxidant effect It manifested in the ability of the drug to influence oxidative stress (cell damage triggered by oxidative stress) and increase the survival of neurons in conditions of oxygen starvation.
The mechanism of action is associated with inhibition of peroxidation and free radical processes lipid cell membranes And correction kislorodozavisimyh pathological conditions.
As a result: it slows down the process of destruction cell membrane Improves microcirculation, decreasing the permeability of the vessel walls , Normal level found in the blood cholesterol and triglycerides .
Tissue-specific effect of the drug is associated with increased intensity CNS neurons metabolism and PNS , Stimulation of reparative processes in CNS , Improvement of functional status the cerebral cortex of the brain and the general tone somatic and autonomic nervous system .
The pharmacokinetic characteristics are given to determine the time since the collapse of a part of the active substance Cortexin amino acids L-series and neuropeptide fractions is not more than 3 minutes.
This makes it impossible to establish the rate and extent of absorption of the peptide residues, their distribution in various organs and tissues, as well as the speed and ways of their excretion from the body.
Indications Cortexin from which the medicine is prescribed for adults and children
The indications for use of the drug are:
- provoked bacteria or Infectious diseases of the nervous system ;
- state, accompanied by violation blood circulation in the brain ;
- TBI and its consequences;
- syndrome of diffuse brain damage different nature of origin;
- cerebral (suprasegmental) autonomic disorders .
In combination with other drugs for the treatment of drug administered epilepsy As well as for the treatment of acute and chronic inflammatory disorders of the brain and / or spinal cord various etiologies.
For children Cortexin indications for use are reduced learning ability, impaired memory and thinking retardation syndrome in a child psychomotor and speech development (ZPRR), various forms of Cerebral Palsy .
Contraindications
The drug is contraindicated in patients with hypersensitivity to Cortexin and / or glycine.
Clinical studies for the determination in the action of the drug on the body of the pregnant woman and the developing fetus is not carried out. For this reason, the drug is not recommended for designation at any stage of pregnancy.
Since these clinical studies regarding the use of the drug during lactation are not available, if necessary, the appointment Cortexin advised to stop breastfeeding.
Side effects of the drug
Potential side effects are possible allergic reactions Due to individual sensitivity to the part of the drug components.
Injections Cortexin: instructions for use
The preparation is intended for administration into the muscle.
Cortexin divorce?
Before injection contained in a vial to dissolve the powder should be one to two milliliters of 0, 5% solution procaine ( novocaine ) saline (isotonic sodium chloride solution (0 9%)) or water for injection.
To prevent the formation of foam needle while trying to send to the wall of the vial.
As a child stabbing Cortexin?
Cortexin allowed to appoint the first days of life. In some situations, parents have to make their own baby shots. This raises the question how to get a shot Cortexin and better plant powder.
Before you make an injection in a syringe collect water for injection, novocaine or saline Then pierce the vial cap and pouring in the liquid typeset.
The syringe should be removed (with the needle still in the cap) and carefully shake the contents of the vial to completely dissolve the powder. Then again, the syringe attached to it and gain the necessary amount of the solution.
To better get a new injection needle, as the needle, which is introduced solvent for the freeze-dried product, it can already be pretty blunt.
The medicine is injected slowly as rapid injection can cause very severe pain.
Infants up to six months by intramuscular injection is the front of the thigh (not to accidentally damage the sciatic nerve).
Babies, especially very small, all the injections were at physiological saline or water for injection. Injections with novocaine less painful than injections on saline However diluted drug novocaine It is permitted only if there is a strong belief that it will not cause allergic reactions the child ( novocaine able to give a strong allergy and convulsions ).
Like other neyrometabolicheskie drugs , Cortexin recommended to prick up to 12 hours a day because of its activating effect and the ability to provoke psychomotor agitation .
Instructions for use for adults Cortexin
Adult patients do Cortexin injections once a day, every day for ten days in a dose of 10 mg.
With massive ischemic stroke (MII) in the acute phase and in the early recovery period, said dose is recommended to be administered to a patient twice a day (morning and evening) for ten days. Ten days later, the course should be repeated.
Instructions for use for children Cortexin
In pediatric medicine is used to treat children from the first days of their lives.
Patients weighing less than 20 kg, the drug is administered at a dose of 0, 5 mg / kg body weight. Patients weighing more than 20 kg, is a dose of 10 mg.
The treatment duration is ten days. If necessary, after three to six months, patients can be assigned to a second course.
The drug is rarely causes side effects, almost no contraindications and can be used to treat even newborn babies. Its main drawback is considered a form of release: Cortexin not available in tablets, and it kind of complicates its use in children, if the latter requires several courses.
Overdose
To date, reports of side effects, which developed as a result of an overdose Cortexin not.
Cooperation
The drug is not compatible with a drug having a peptide structure.
Terms of sale
The drug belongs to the category of prescription drugs and should only be dispensed from pharmacies by prescription.
Storage conditions
Cortexin should be stored in a dry place protected from sunlight at temperatures between 2 and 20 ° C.
Shelf life
Pass to the application within 36 months from the date of manufacture.
Cautions
The drug is available only in the form of freeze-dried product, Cortexin tablets is not made.
The drug should not be mixed in the same syringe with any other drugs.
Analogs Cortexin
Cere
Noben
Omaron
Pantogam
Pantogam Active
Tiotsetam
Noopept
Kogitum
Encephabol
Tserakson
Pikamilon
Phenotropil
Nootropil
Vinpocetine
Aminalon
Fezam
Pyracetam
Cavinton
Semaks
Analogs Cortexin tablets: Armadin and Lone Armadin g Bolus Huato . Borizol . Glitsised . Mexidol . Meksiprim . Glutamic acid . Rilutek . Citoflavin .
Analogs Cortexin ampoules: Armadin . Meksiprim . Neurotrophins . Nikomeks . Nucleo CMF Forte . Citoflavin .
Cortexin or Tserebroliziin - which is better?
The studies carried out on laboratory rats showed that Cere and Cortexin by intraperitoneal injection and the introduction of procelia They have a similar effect.
A comparative analysis of the central effects of drugs led to the conclusion that in spite of their similarity greater activity differs Cortexin.
Thus far it provokes fewer adverse reactions and can be used from birth (whereas Cere pediatric use if there is reasonable evidence).
According to some patients, injections Cere less painful compared to injections Cortexin.
Cortexin children
Instructions for use for children Cortexin authorizes the use of the drug in the first days of life.
Reviews Cortexin doctors for children's products support the statement that the drug is virtually no side reactions allergies Without having teratogenic and carcinogenic effects and well tolerated by patients.
Its use in neurology, neonatology and pediatrics can improve the child's behavior and its overall state at various kinds of tone, normalize the function of memory and speech, relieve headaches.
Reviews Cortexin
Cortexin - a drug widely used in neurological practice. Reviews Cortexin for adults, which can be found on many online forums, testify to the effectiveness of this treatment for patients of all ages (for infants, as well as for elderly people).
The drug speeds up the process of recovery after trauma and stroke And the elderly stimulates brain It increases the ability to memorize and concentrate, as well as prevents the reduction of intellectual abilities.
Reviews Cortexin children allow us to conclude that the drug is often administered to children who have observed certain deviations in neuropsychological development. In particular, indications for use of the drug is Cerebral Palsy and brain damage That occurred during the prenatal period (close to the date of birth), or directly in the process of childbirth.
Injections of children - and reviews of Cortexin proof of that - can achieve significant improvements: after a course of treatment with the child becomes calmer, he noted improvement in brain activity, increased interest in learning, improve memory and speech.
Use of the drug for infants (particularly for babies who were born prematurely) allows a fairly short period of time to notice obvious improvements that are manifested in a quiet child's behavior or appearance of his new skills (eg, ability to independently turn over from back to stomach and back).
Mothers, children who are appointed Cortexin note that after treatment the child literally "came to life before our eyes." Advantages of the drug, many believe the lack of side effects and low toxicity. As minuses often indicate a fairly high price means and painful injections.
As for the comments about Cortexin doctors, they, despite the rather high assessment of the drug on the forums (on average 4, 1-4, 3 to 5-point scale), quite contradictory: some doctors consider it a panacea, while others - a pacifier with unproven effectiveness .
Price Cortexin
Price Cortexin 10 mg in Ukraine - 598-685 UAH, the price Cortexin jabs for children varies from 440 to 520 UAH. In Dnepropetrovsk, Zaporozhye, Donetsk and other cities to buy the drug can be in a network of retail pharmacies and through an online pharmacy with delivery directly to your home.
Average price Cortexin in 5 ml ampoules in Russia - 2700 rubles, the average value of 5 mg vials - 4150-4200 rubles.
The drug is not available in tablets.
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