ACC

Description overdue on 12.03.2012

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Mucolytics . The active component is acetylcysteine . The drug promotes the separation and liquefaction of sputum, its volume increases. The pharmacological action of the drug ACC is to eliminate intermolecular disulfide bonds mukopolisaharidov sputum through free sulfhydryl groups. This leads to an increase and decrease sputum viscosity. Active and purulent sputum. The effects on the immune system have been identified. ACC reduces adhesion of bacteria in the bronchial mucosa, increases the secretion of a liquid sialomutsinov goblet cells. The drug stimulates the lysing fibrin. The information contained in the SH-ACC team has an antioxidant effect and neutralizes oxygen-electrophilic toxins. The preparation of alpha1-antitrypsin protects from the inactivating effect of HOCl - oxidant produced active phagocytes . Acetylcysteine ​​stimulates bronchial secretions to produce destroying fibrin . Also, the drug has an effect on the secret, resulting in inflammation of the upper respiratory tract. Inhibits the formation of free radicals, and various oxygen-containing compounds, providing anti-inflammatory . ACC is released in the granules to prepare a solution, a syrup, a suspension for oral administration, or as a solution.

Indications:

ACC is prescribed for tracheitis , Bronchitis, violation of the outflow of mucus, laryngotracheitis , Emphysema, lung abscess, bronchiectasis, pneumonia, bronchiolitis, pulmonary atelectasis, cystic fibrosis , Purulent and catarrhal otitis, sinusitis (improves the outflow of secretions), sinusitis. The drug is prescribed in preparation for bronhografii, bronchoscopy, aspiration drainage. The drug helps to remove secretions in the postoperative and post-traumatic states. ACC is assigned for washing of the middle ear, sinuses, nasal passages, abscesses; for the treatment of the surgical field during operations on the mastoid.

Contraindications:

ACC is not indicated during pregnancy, hypersensitivity, breastfeeding. Use with caution: pulmonary hemorrhage, hypertension, hemoptysis, varicose veins of the esophagus, liver or kidney failure, adrenal disease, bronchial asthma (risk of bronchospasm) peptic ulcer .

Side effects and overdose:

ACC can cause febrile syndrome, feeling of fullness, hives , Nosebleeds, nausea, vomiting, tinnitus. Less registered dyspepsia . An aerosol form of the drug causes rhinorrhea, stomatitis, respiratory tract irritation, coughing. When administered intramuscularly: itching at the injection site, disruption of the renal or hepatic systems. If overdose is registered vomiting, diarrhea, epigastric pain, heartburn Nausea. Treatment posindromnoe.

Mode of application:

Adults - 200 mg three times a day as tablets, capsules or granules .  In the case of long-term chronic disease: adults - 500 mg per day in one or two steps .  For use in ultrasonic devices, the use of 20 ml of 10% percent solution and 3 ml of 20% solution, in the apparatus having the control valve - 6 mL of 10% solution .  The duration of inhalation - about 15-20 minutes, three times a day .  In the case of an acute condition, the duration of treatment 5-10sutok; for the treatment of chronic conditions - up to 6 months .  When strongly expressed the secret development of the frequency and dose of inhaled cut .  If necessary, the secret aspirated .  Intratracheal .  For therapeutic lavage and bronchial tree during bronchoscopy using 5-10% solution of the drug .  For topical use, the drug was instilled into the nasal sinuses or the external auditory canal in an amount of about 200 mg per procedure .  When administered intravenously (bolus or slow infusion), adults - 300 mg once or twice a day .  A child aged 6 -14 years - appoint 150 mg once or twice daily .  Children up to six years recommended oral medication ACC, children under one year intravenous administration is possible only in a hospital in the presence of Dr. .  The duration of therapy is chosen on the basis of individual performance (no more than 10 days) in elderly people use the minimum dose .

Special indications:

In the treatment of diabetes, it is necessary to consider the sucrose contained in the granulate formulation. In order to avoid burning, drug ACC should be administered deeply into the muscle. When treating bronchial obstruction It is recommended to combine with bronchodilators.

Drug Interactions:

When used together, acetylcysteine ​​and antitussives may be stagnant mucus. Acetylcysteine ​​is incompatible with tetracycline, erythromycin, cephalosporins, penicillins. When interacting with the rubber, metal sulfides are formed with a sharp odor.