Buserelin

Description overdue on 09.10.2011

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The preparation buserelin   It is an antineoplastic agent and has anti-androgenic effects . After its action occurs communication with the cell receptors in the anterior pituitary. This provokes an increase in the concentration of hormones   in plasma for a short time. If you continue to use the drug for medicinal buserelin doses, approximately 12-14 days later, there is a complete blockage gonadotrophic pituitary function .

The drug reduces the formation of LH, FSH, reduces the synthesis of testosterone . Because of this synthesis of sex hormones in the gonads suppressed, then decreases in plasma concentration estradioda   to the values ​​of post-menopausal (women) and reduced maintenance Testosterone   postcastration to level (men). Provided continuous therapy for two to three weeks, the concentration of testosterone is reduced to content, which is typical for the state orchiectomy . The result is a pharmacological castration .

Indications and methods of use of the drug:

The drug is prescribed to patients buserelin prostate cancer If there is a need to inhibit the production of testosterone in the testes; a drug used to treat Breast Cancer , Hormone-dependent diseases of the reproductive system, which is due giperestrogeniey : Endometriosis , Uterine fibroids, endometrial hyperplasia. Also, the drug used in the treatment of infertility .

For administration of the drug intramuscularly suspension should be prepared immediately before its introduction. The vial should be thoroughly stir until slurry is not homogeneous. It needs to dial into a syringe, it does not turn the bottle. The needle is replaced, and then quickly perform an injection.

Patients with prostate cancer is administered at 4.2 mg once every four weeks. Patients with endometrial hyperplasia, endometriosis, administered at 4.2 mg once every four weeks. Therapy should begin in the first five days of the cycle. The treatment lasts for five months. Patients with uterine cancer is administered 4.2 mg every four weeks. Therapy should begin in the first five days of the cycle. The treatment lasts three months before the operation, in other cases - for six months. In the treatment of infertility by IVF   4.2 mg administered at once on the second day of the menstrual cycle.

Also, the drug is used buserelin intranasally . In the treatment of some diseases - uterine fibroids , Endometriosis, endometrial hyperplasia - a drug is introduced into the nasal passages. The dose is 900 micrograms a day. The dose prescribed for a day, it is necessary to introduce equal portions. In each nostril three times a day administered a single dose. Between doses should undergo an equal amount of time. Treatment begins on the first or second day of the cycle.

In the treatment of infertility by IVF drug buserelin take 600 micrograms a day. Thus a single dose (150 ug) is inserted into nostril four times a den.Mezhdu dosing should undergo an equal amount of time. Taking the drug need to start from the middle of the menstrual cycle. Re-treatment may be carried out only after a thorough examination.

Contraindications and possible side effects:

Buserelin should not be taken in patients with severe hypersensitivity to the drug. The drug is not prescribed in the state after surgical removal of the testes. It is contraindicated in pregnant or lactating. C care administered buserelin obstruction of the urinary tract, metastases   spine, when hypertension , Depression, diabetes .

Before the drug may be a manifestation of a number of side effects. In work   CNS : May be headache, nervousness, dizziness, fatigue condition, sleep disturbances or drowsiness, poor memory and ability to concentrate, anxiety, depression. In work senses :   manifest tinnitus, impaired vision and hearing. In work Endocrine : Patients may experience "tides" of blood to the face and top of the chest, profuse sweating, decrease in potency and libido .

Women taking the drug when can feel vaginal dryness , Pain in the abdomen, bleeding rarely menstrualnopodobnoe at the beginning of therapy. Men may notice worsening and the progress of the underlying disease, they also can be observed gynecomastia . In work   Digestive System : Can occur nausea, vomiting, diarrhea, thirst . constipation , Problems with appetite, weight fluctuations.

In work   CCC : Heartbeat, increased blood pressure. As a side effect may be a number of allergy.

Rarely nosebleeds, pulmonary embolism , Increase in the intensity of pain in the bones, swelling, and local reactions may occur with the introduction of the drug.

Specific recommendations:

Patients with depression should be carefully monitored by a specialist during the treatment. Before starting therapy should exclude pregnancy, stop hormonal contraceptives. If buserelin accept patients with rhinitis, before taking his need to clear the nasal passages. During treatment, you need to be wary of driving transport and other activities that require attention. The drug significantly reduces the effect of hypoglycemic agents .