Olfen-75

Description overdue on 10/13/2014

• Latin name: Olfen-75
• ATC code: M01AB55
• Active substance: Diclofenac sodium (Diclofenac sodium), Lidocaine hydrochloride (Lidocaine hydrochloride)
• Manufacturer: Mepha LLC (Switzerland)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Olfen (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Reviews
• Price, where to buy

Composition

The active ingredients of the drug: diclofenac sodium   and Lidocaine hydrochloride .

Additional components - acetylcysteine . propylene glycol . Sodium hydroxide . polyethylene glycol 400 . Water for Injection .

Product form

The drug is available as a solution for injection.

Pharmacological action

This tool refers to nonsteroidal antiinflammatory drugs.

Pharmacodynamics and pharmacokinetics

Active component Olfen-75 - diclofenac sodium   It belongs to nonsteroidal   Drugs with significant antirheumatic . anesthetics .   anti-inflammatory   and antipyretic   properties. At the heart of its action is preventing the biosynthesis prostaglandins Which affect inflammation, fever and pain.

At rheumatic   disease drug helps relieve signs and symptoms of illness, it takes away the pain, normalizes the joints and eliminate stiffness. In case of inflammation after injuries and operations Olfen-75 contributes to the rapid disappearance of pain, reduces the severity of edema   due to injuries and inflammation. Moreover, it largely reduces the need to use opioids . This drug is also effective as an analgesic for diseases rheumatic   origin. It reduces the pain within 15-30 minutes after the internal administration.

This facility is well suited for the start of the treatment of many inflammatory diseases.

The extent of its plasma protein binding of almost 100%. He gets into synovial fluid . The maximum concentration of the drug is achieved within 2-4 hours after the peak concentration. Half-life synovial fluid   - About 4-5 hours. High concentrations diclofenac sodium   at   synovial fluid   observed 12 hours later.

The preparation metabolized   in part by glyukuronirovaniya   and methoxylation   to form active phenolic metabolites .

Time-life vehicles - about 1, 5 hours. About 60% is excreted through the kidneys in the form   metabolites   and less than 1% - unchanged. The remaining amount is displayed in metabolize   the form of bile and feces.

Indications

The drug is used for:

• exacerbations rheumatism : rheumatoid arthritis . osteoarthritis . vertebral   pain syndromes, ankylosing spondylitis . spondylitis .   articular rheumatism ;
• kidney and liver   colic ;
• acute attacks gout ;
• pain, swelling and inflammation after injuries and operations.

Contraindications

Injections Olfena not be used when:

• hypersensitivity   to component drugs;
• a history of seizures because of lidocaine;
• cases bronchospasm . nasal polyps , Acute rhinitis . hives   (and other allergic reactions that can be caused by acetylsalicylic acid   or other NSAIDs ) at history ;
• bleeding in the gastrointestinal tract or perforations ;
• gastric ulcer and / or duodenal ulcers   during exacerbation;
• inflammatory bowel disease;
• heavy hepatic insufficiency ;
• hypovolemia   or gipogidrii ;
• renal failure   in moderate to severe stages;
• atrioventikulyarnoy blockade   II and III level;
• Stokes-Adams syndrome ;
• bradycardia ;
• full transverse heart block ;
• heavy Heart Failure ;
• sick sinus syndrome ;
• expressed hypotension ;
• cardiogenic shock ;
• the treatment of pain after coronary artery bypass grafting   or use of the heart-lung machine;
• increased likelihood of post surgical bleeding disorders hematopoiesis , Bleeding, incomplete hemostasis ;
• porphyria ;
• myasthenia .

Side effects

If you are using vials Olfen-75 there any adverse reaction, you should immediately consult a specialist.

In very rare cases, the injection site may occur abscesses . In addition, when using this drug are known cases of the following side effects:

• CNS - headache . dizziness ;
• senses - vertigo ;
• GIT - pain in the abdomen, vomiting, spasms . flatulence , Nausea, diarrhea . dyspepsia . anorexia ;
• hepatobiliary system - an elevated level transaminases ;
• kidney and urinary tract - fluid retention, edema;
• skin and skin - rash;
• General disorders - reactions at the injection site.

Also, in rare cases can occur: thrombocytopenia . anemia . leukopenia . agranulocytosis Hypersensitivity reactions angioedema , Numbness, feeling hot / cold, disorientation, insomnia , Irritability, depression , Nightmares, mental disorders.

Infrequently reported occurrence sleepiness . paresthesia , Seizures, aseptic meningitis . stroke , Impaired memory, vision, hearing, taste, anxiety, tremor . diplopia Tinnitus.

In addition, there are reports of side effects from the cardiovascular system as tachycardia, heart attack . arterial hypertension . arrhythmia , chest pain, heart failure . vasculitis . bradycardia . From the side of respiratory noted the appearance Asthma . bronchospasm . pneumonitis   and respiratory depression. There are also rare reports gastritis , Vomiting with blood secretions, Melun , Bleeding in the gastrointestinal tract, gastric or intestinal, colitis . stomatitis , Lesions of the esophagus, pancreatitis . constipation . glossitis . diafragmopodobnyh intestinal strictures .

Rare manifestations of side effects after taking Olfena-75 and carry hepatitis , Dysfunction and necrosis   liver jaundice . liver failure . hives . erythema . Stevens-Johnson syndrome . exfoliative dermatitis . photosensitization . allergic purpura . itch . eczema . toxic epidermal necrolysis . alopecia , Acute renal failure . proteinuria . nephrotic syndrome . hematuria . interstitial nephritis . renal papillary necrosis .

Instructions for use Olfen (method and dosage)

The dosage, which uses ampoules Olfen-75 is selected for each patient individually . The minimum dose is taken during the least possible time.

Instruction in Olfen also recommends to conduct pre skin test hypersensitivity to constituents of the preparation. In the absence of adverse reactions continue to use means in the form intramuscular infusion .

Typically, dosage is administered on a one-time 75 mg Olfen ampoules applied 1 time a day. The injections are administered into the upper outer quadrant of the gluteus maximus. Immediately after the ampoule is opened, the solution should be used. If you open the ampoule remains unused solution, it needs to be disposed of.

When severe pain if used injections Olfena, instructions for use recommends to inject 2 times per day with a break of a few hours between them. Place the infusion when it should be different. Acceptable combination with other medicinal forms Olfena, but the maximum daily dose should not exceed 150 mg.

While parenteral   Use of the drug should not be longer than 2 days. If necessary, continue therapy Olfen-75 is replaced by other forms of the drug. Furthermore, the tool can not be used for intravenous administration.

Overdose

Typical symptoms of overdose diclofenac sodium   It is not set. In applying the drug in high doses can be vomiting . diarrhea As well as the emergence of tinnitus . bleeding in the gastrointestinal tract . dizziness . seizures . With a strong overdose can develop acute renal failure . liver .

Lidocaine hydrochloride   in high doses can cause numbness of the tongue and lips, euphoria, blurred vision, depression, shortness of breath, violation cardiac conduction . coma , Restlessness, anxiety, tremor . sleepiness . bradycardia . transverse heart block .

Symptomatic therapy. Forced diuresis . hemoperfusion   or dialysis   in most cases, are not effective.

Cooperation

Olfen-75 increases the content of lithium and digoxin in the blood plasma, so it is recommended to control their dosage.

Combination with diuretics   or antihypertensive   drugs may reduce antihypertensive effect . Olfen-75 should be used with caution, watching the patient. During the course of treatment with these drugs need to drink plenty of fluids and monitor the work of the kidneys. When combined with potassium-sparing diuretics   may develop hyperkalemia So that periodically determine the content of potassium in serum.

The interaction with the system NSAIDs   or GCS Diclofenac may contribute to the appearance of adverse reactions from the gastrointestinal tract. Furthermore, it should be used with caution with anticoagulants . SSRIs   and antiplatelet agents As it may cause bleeding. Combination with anticoagulants   It may also increase the risk of hemorrhagic complications . So the condition of patients should be carefully monitored.

Precautions must be taken Olfen-75 hypoglycemic agents Intended for oral   use. It is recommended to monitor blood sugar levels.

This drug can also increase the toxicity and content Methotrexate   in blood, nephrotoxicity Tacrolimus   or Cyclosporine . Therefore dosage adjustment is required.

Olfen-75 in combination with quinolones   can lead to the development of seizures. Phenytoin   increases its cardiodepressive   action. Ethanol   dampening effect on the respiratory system.

The extent of absorption diclofenac   reduced by about 30% while the use of Colestipol   and 60% with Cholestyramine . It should take them with a break of a few hours.

Drugs that stimulate the enzymes metabolizing   preparations can reduce the concentration of diclofenac   in blood plasma.

Beta-blockers . Cimetidine . Bupivacaine . Dizopiramid . Nortriptyline . Imipramine . Propranolol . Peptidin . Quinidine . Amitriptyline . Chlorpromazine   contribute to the increase of content lidocaine   in serum, reducing its hepatic metabolism . Intoxication cardiac glycosides   it can also worsen the severity AV-blockade . Besides that, Lidocaine   decreases cardiotonic   effect cardiac glycosides Increases cardiodepressive   action antiarrhythmic   and anticonvulsants   funds increases CNS depression sedatives   and hypnotics   drugs, as well as the action of drugs affecting the blockade neuromuscular transmission . It may lead to delusions and hallucinations   together with Procainamide .

Terms of sale

Olfen-75 available on medical prescription.

Storage conditions

Keep the medication you need to reach children at a temperature of 25 ° C.

Shelf life

Five years.

Reviews

Reviews of this preparation mostly positive. However, patients sometimes complain of side effects with him. However, they note that the undesirable effects clearly less than with many other similar drugs.

Price Olfen-75, where to buy

This tool can be purchased in Ukraine. Price Olfen-75 is about 100 hryvnia.

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