Memantine

Description overdue on 01/12/2014

• Latin name: Memantin
• ATC code: N06DX01
• Active substance: Memantine (Memantin)
• Manufacturer: Synthon Hispania S.L. (Spain)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use of Memantine (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The medicine contains memantine hydrochloride   as a main component.

Product form

The drug may be sold in the form of a powder substance, and tablets.

Pharmacological action

This tool provides antispasticheskoe . antiparkinsonian   and neuroprotective   action.

Pharmacodynamics and pharmacokinetics

The drug is a blocker NMDA-receptor . It inhibits the action of elevated levels Glutamate   and thereby prevent neuronal dysfunction. It improves mental activity and normalizes motor disorders.

The maximum content in plasma is about 3-8 hours later. Meals do not affect the absorption . Bioavailability   the drug is about 100%.

At doses of 10-40 mg pharmacokinetics is characterized by linearity. About 45% of the active ingredient binds to plasma proteins. Approximately 80% is circulated in the original form.

Write mainly by the kidneys. The half-life is 60-100 hours. The elimination rate may be reduced to 7-9 times in the case of alkalinization of urine. This may be due to drastic changes in diet. For example, if before it was rich in meat dishes, and then there was a sudden transition to a vegetarian menu. Furthermore, such an effect is possible due to the use of antacids .

Indications

The medicine is used in dementia   and Alzheimer's disease   in different forms. Furthermore, when it is used spinal   and cerebral spastic syndrome , Problems with the nervous system, Parkinsonism . Parkinson's disease .

Contraindications

Do not use the tool in case of hypersensitivity to its components, confusion . breastfeeding , Significant impairment of renal function, pregnancy .

Side effects

Generally, the following noticeable adverse effects that may be associated with the drug: confusion, hallucinations . dizziness , A sense of fatigue, headache . anxiety , Vomiting, increased libido, increased muscle tone, cystitis . Also, sometimes it reported on epileptic seizures . This usually happens if you have previously convulsions .

Instructions for use of Memantine (method and dosage)

Instructions on Memantine reports that he intended to oral   use. Treatment is desirable to start with a minimal dosage, which are selected individually. The initial daily dose for adults - 5 mg. If necessary, it can be increased weekly by 5 mg. The recommended maintenance dose - 10-20 mg per day. Raise it can be up to 60 mg. If there are problems with the kidney function, the dosage should be reduced.

Instructions for use of Memantine recommends giving children 0, 5 mg per kg of body weight every day. If you have problems with the kidneys, the drug should be taken under the supervision of their functional state.

It is advisable to give at the time of taking the medicine from driving, maintenance tools and other activities, which need special attention.

Overdose

At the use of the drug in high doses can appear anxiety, visual hallucinations, drowsiness, loss of consciousness, psychosis, convulsive readiness, stupor. Symptomatic therapy.

Cooperation

The drug affects the effect   dopamine receptor agonists . neuroleptics . barbiturates . anticholinergics . Amantadine . Levodopa . Furthermore, it may modify the action of Baclofen   and Dantrolene . So you may need adjustment of their dosages.

Do not take at the same time Phenytoin . And interaction with preparations containing hydrochlorothiazide, can lead to reduction of the latter in the blood plasma.

We must avoid the combination of the drug with N-methyl-D-aspartate antagonists . Otherwise, it can cause the appearance of side effects.

Terms of sale

The drug is sold by prescription.

Storage conditions

Storage temperature should be 25 ° C. Keep the tool should be out of the reach of small children.

Shelf life

Keep the drug should be no longer than two years.

Memantine analogs

Match code ATC 4th level:

• Memoplant
• Ginkoum
• Vitrum Memory
• Namenda
• Memantine akatinol

Your doctor may prescribe Memantine following analogues:

• Maruksa ;
• Memorel ;
• Memantine akatinol ;
• Alzeym ;
• Memaneyrin ;
• Memantine hydrochloride ;
• Memantal ;
• Memantinol ;
• Memantine Canon ;
• Memikar ;
• Memantine-TL ;
• Noodzheron .

Not one of them should make their own without consulting with a specialist.

Reviews of memantine

Doctors about memantine suggests that the drug is quite effective if used according to indications. It helps patients in dementia   and other diseases when used strictly in accordance with the appointment of specialists. Reviews of memantine patients rarely left, but the negative is not among them.

Price Memantine, where to buy

Price Memantine tablets 10 mg about 1350 rubles. Such drug cost is considered rather high. Nevertheless, Memantine price lower than the cost of the more common analogs thereof.

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