Description overdue on 09/18/2014
- Latin name: Nimid Forte
- ATC code: M01AX67
- Active substance: Nimesulide + tizanidine hydrochloride (Nimesulide + Tizanidine hydrochloride)
- Manufacturer: Kusum Heltker Pvt. Ltd., India
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Nimid Forte Tablets (Method and dosage)
- Overdose
- Cooperation
- Cautions
- During pregnancy (and lactation)
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
The tablets contain the active substance: Nimesulide - 100 mg Tizanidine hydrochloride - 2 mg.
Additional ingredients: microcrystalline cellulose, magnesium stearate, croscarmellose sodium, colloidal anhydrous silica.
Product form
Available Nimid Forte in the form of tablets. 10 pieces in a blister, and 10 blisters per pack.
Pharmacological action
Forte Tablets have Nimid analgesic, antipyretic and anti-inflammatory action .
Pharmacodynamics and pharmacokinetics
The effect of this combination preparation leads to the pharmacological properties of its constituent materials. Nimesulide shows analgesic, antipyretic and antiphlogistic effect.
Tizanidine It is relaxant the central action. It is noted selective inhibition of polysynaptic reflexes of the spinal cord involved in the regulation of muscle tone. The component shows efficacy in the treatment of muscle spasms with acute pain and chronic spasms of cerebral and spinal origin. It also reduces production of superoxide anion, which prevents further tissue damage.
Inside the body there is a rapid absorption from the gastrointestinal tract of nimesulide. Then, after 2-3 hours in the composition is determined by the maximum plasma concentration of the substance. Also installed its almost complete connection to plasma proteins. The metabolism of the drug is carried principally in the liver and the result of this process is the formation of hydroxynimesulide - A pharmacologically active component. Most of nimesulide is excreted in the urine, and the rest - with the feces.
Tizanidine absorption from the gastrointestinal tract occurs as quickly and fully. Maximum concentration in the blood plasma of the composition formed after 1 h. Approximately one third substance is bound to blood proteins. During metabolism Tizanidine in the liver, does not appear pharmacologically active metabolites . Derived substances within 2-4 hours, preferably by the kidneys.
Indications
This drug is prescribed for:
- acute pain caused by spasms of skeletal muscles;
- vertebroalgii;
- ankylosing spondylitis.
Contraindications
Nimid Forte is not recommended for patients:
- with gastric ulcer and 12 tiperstnoj intestine in acute;
- severe disorders of the liver, such as liver failure, hepatotoxic reactions to the drug, while the application is potentially hepatotoxic agents;
- severely impaired renal function and blood clotting;
- severe heart failure;
- hypersensitivity to the drug;
- during lactation, pregnancy;
- 18;
- patients alcoholism, drug addiction and so on.
Side effects
As a rule, reception Nimid Forte can cause side effects only at the beginning of treatment. This adverse event may provoke its active components individually.
When treating nimesulide often arise skin reactions: itching, rash, increased sweating, dermatitis, erythema and so on. Also, deviations in the activities of the gastrointestinal tract: pain, nausea, gastritis, diarrhea, constipation and others.
Some patients suffer from liver, kidney, nervous and immune system, develop mental disorders and abnormalities in the blood and the hematopoietic system.
Admission tizanidine leads to mental disorders, problems in the nervous, cardiovascular, digestive, immune, and musculoskeletal system. Not excluded hepatobiliary disorders, blood pathology, and general deviations - weakness, fatigue, flu-like conditions and fatigue.
Instructions for use Nimid Forte Tablets (Method and dosage)
Nimid Forte Tablets are recommended for use after meals. The dosage and duration of therapy is determined by the doctor. Typical cases require appointments for adult patients on 100 mg 2 times a day.
The instructions on Nimid Forte says that the maximum daily dosage should not exceed 400 mg.
Children older than 12 years, the calculation is performed daily dosage of 1, 5 mg per 1 kg of body weight. The maximum daily dose will not be greater than 5 mg per kg body weight.
Overdose
Cases of overdose may be accompanied by: lethargy, sleepiness , Nausea, vomiting, abdominal pain , Gastrointestinal bleeding, acute forms of kidney and liver failure, respiratory depression and so on.
For specific treatments are not developed antidote So symptomatic therapy including gastric lavage and activated charcoal technique. At the same time carry out continuous monitoring of the kidneys and liver.
Cooperation
The simultaneous use warfarin Similar anticoagulants . acetylsalicylic acid - Can lead to bleeding.
In the treatment of patients with impaired renal function and heart need to be careful in appointing a nimesulide furosemide . NSAIDs may reduce the clearance of lithium is able to increase the lithium content in the blood and its toxic effects. For this reason, a special need to monitor the concentration of lithium in the composition of the blood plasma.
There suppression effectiveness of nimesulide enzyme CYP 2C9 , Because of which increases the blood concentration of the drugs that interact with the enzyme.
The combination of Nimesulide with cyclosporin increases their nephrotoxicity with antihypertensives - causes development bradycardia and hypotension With sedatives - it enhances the pharmacological effect of the drug.
Do not combine with tizanidine fluvoxamine and ciprofloxacin That inhibit CYP450 1A2.
Treatment tizanidine and other inhibitors of CYP1A2 , eg, antiarrhythmic drugs - a miodaronom, mekseletinom, propafenone, and cimetidine, fluoroquinol - enoxacin, pefloxacin and norfloxacin, oral contraceptives and tiklopiridinom can enhance the action of this medication. Admission and tizanidine antihypertensive drugs , including diuretics May cause hypotension and bradycardia .
Cautions
To reduce the risk of side effects is recommended to use the lowest effective dose with a short therapeutic course. If the treatment does not bring quick relief, it stopped.
An increase in hepatic enzymes or indicators of the development of signs of liver damage, for example in the form of anorexia, nausea, vomiting, abdominal pain, fatigue, changes in urine color, the drug immediately overturned in the future avoid treating nimesulide.
Treatment Nimidom Forte can cause bleeding in the digestive tract or ulcerative lesions, which also requires discontinuation of the drug. Caution should be exercised when treating patients with abnormalities of the gastrointestinal tract, Crohn's disease, ulcerative colitis , Renal or cardiac failure.
Elderly patients taking the drug, could be affected by the development of side effects in the form of gastrointestinal bleeding, perforation, violations of the heart, kidneys and liver. For this reason, they need regular clinical monitoring of general condition.
Acceptance of this drug and other NSAIDs are often mask fever, pertaining to the background bacterial infection . If it is found that the temperature of the body, the manifestation of flu-like symptoms, the treatment is stopped immediately.
Throughout the therapy should be careful when driving and other potentially dangerous activities requiring a high concentration of attention and fast psychomotor reactions.
Pregnancy and breast-feeding
This drug strictly contraindicated a reception at pregnancy and Lactation . The fact that established the influence of nimesulide on female fertility, so from its reception should refrain even when planning a pregnancy. Treatment of nimesulide often becomes the cause of the early closure of ductus arteriosus, pulmonary hypertension . oligohydramnios and oliguria . Also increases the risk of bleeding, peripheral edema and uterine atony.
Terms of sale
Tablets of prescription.
Storage conditions
Nimid Forte stored at temperatures up to 25 ° C, protected from children.
Shelf life
3 years.
Analogs
Glucosamine Chondroitin-
Glucosamine
Glucosamine hydrochloride
Glucosamine Maximum
Nutrilite Glucosamine
Nimid
Struktum
Hondrogard
Artradol
Kartilag Vitrum
Mukosat
Glucosamine sulfate
Nimesulide
Chondroitin sulfate
Nimulid
Nimesil
The main counterparts of this drug include: Nimesulide, Nise, Mesulid, Nimesil, Nimegesik and Nimid .
Alcohol
When treating Nimidom Forte should give up drinking alcohol, because this combination can cause the development of serious side effects. In addition, alcohol significantly increases the sedative effect of tizanidine.
Reviews of Forte Nimid
Various forms of the drug Nimid are very popular with patients. Therefore, reviews of Forte Nimid are quite common and many of them positive.
Patients using this drug in the various forms of pain: headache, toothache, menstrual, joints and so on. They often say that the tablet quickly reduce pain and do not cause side effects. At the same time eliminating the pain, people do not know about the reasons for its occurrence, and not even aware of the possibility of complications. In addition, taking medication, do not understand, from what Nimid Forte tablets and are confident that it is a simple analgesic Which is intended for disposal of pain in the gastrointestinal tract.
Experts do not recommend to abuse any non-steroidal anti-inflammatory drugs group. Although for them, and it is characterized by rapid action, which greatly facilitates the patient's condition, but it does not solve the underlying problem of pain. Therefore, if the pain resumes, it is necessary to visit a doctor.
Price Nimid Forte tablets, where to buy
The Russian Store Price Nimid Forte tablets 100 pieces in a package is 1057 rubles.
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