Kromoglin

Description overdue on 20.02.2012

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Remedy allergies . The main active substance is cromoglicic acid . The drug has a membrane stabilizing effect, slows down the process degranulation   mast cells, inhibits the release of histamine , Prostaglandins, leukotrienes, bradykinin, bioactive substances. The drug prevents bronchospasm . Due to inhibition of mediator in the pulmonary response system prevents the formation of early and late stages asthmatic response . Kromoglin effectively used for the prevention of allergic reactions (in the immediate type) in young patients (chronic no irreversible changes in the pulmonary system). The drug is ineffective in already developed bronchospasm. When long-term therapy reduced the frequency of asthma attacks, reducing the need for bronchodilators and glucocorticosteroids It facilitated the disease. After 2-4 weeks of regular use, the stable effect. When a single application cromoglicic acid of up to five hours. Kromoglin available as aerosol, powder, solution, spray, eye drops.

Indications and contraindications:

Kromroglin indicated for prevention of bronchospasm attacks of asthma, COPD. The drug is not used in pediatrics, intolerance kromoglitsievoy acid during pregnancy. In the pathology of renal and hepatic systems, breastfeeding is prescribed with caution.

Side effect:

Respiratory system:   a transient breathlessness Cough, hoarseness, slight irritation of the bronchial tree. Digestive system: dyspepsia , Dry mouth, using the marked aerosol unpleasant mouthfeel. Nervous system:   headaches, dizziness. Urinary system:   minor violations in the work of the renal system, recurrent urinary retention. Perhaps the development of anaphylaxis , Watery eyes, hives , Difficulty breathing crowing, swelling of the eyelids, lips.

Mode of application:

Kromoglin used inhalation. Capsules containing powder for inhalation, ingestion of the drug is not effective. With help spinhalera   carried inhalation contents of capsules 4 times a day (2 x day, one time in the morning, one in the evening time). If necessary, the dosage may be increased to 160mg per day. In one metered dose of aerosol for inhalation containing 1 mg, is applied 4 times per day. After reaching the optimal therapeutic effect switching to maintenance therapy. In severe pathology dosage is increased up to 20 mg four times a day. Avoid abrupt discontinuation of the drug Kromoglin, reduce the dosage gradually over a week during this period may increase the disease. Solution for inhalation use Kromoglin 4 times a day to 20 mg using a special inhaler. Spray thoroughly shaken before use. Aerosol in an upright position with the dispensing valve located at the bottom.

Special instructions:

Besides these side effects relatively rare but occur: dysuria , Dizziness, cough, bronchospasm, headache, swelling of joints, tearing, angioneurotic edema, arthralgia, rash, swelling of salivary parotid glands, rash, nasal congestion, nausea, swelling of the throat. During the tapering glucocorticosteroids patient should be observed at the attending physician, the dosage is calculated according to the following scheme: 10% of the dose received in a week. When dose reduction is rarely observed exfoliative dermatitis, anemia, periarteritis, nephropathy,   myalgia , Hoarseness, hemoptysis, pulmonary infiltrates with eosinophilia, polymyositis , Photodermatitis, peripheral neuritis, pericarditis . Kromoglin not suppresses attack of established bronchospasm. In the study the animals were observed not teratogenic and carcinogenic effect of the drug.

Drug Interactions:

Theophylline, corticosteroids, beta adrenostimulyatorov   and antihistamines can enhance effective action kromoglitsievoy acid. At the same time taking the drug Kromoglin corticosteroids can be reduced and the dosage of the latter, and in some cases completely canceled. Inhalation Solution with Kromoglin ambroxol   and Bromhexinum incompatible. Bronchodilators   it is recommended to take immediately before inhalation.