Ambrogeksal

Description overdue on 05/30/2014

• Latin name: AmbroHEXAL
• ATC code: R05CB06
• Active substance: Abmroksola hydrochloride
• Manufacturer: Pharma GmbH Salyutas, Germany

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use ambrogeksal (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One tablet ambrogeksal   contains ambroxol hydrochloride   (active ingredient) - 0 03 + g adjuvants ( calcium hydrogen phosphate, corn starch, magnesium stearate, lactose monohydrate, sodium carboxymethyl starch, colloidal silicon dioxide ).

Capsules   (prolonged release) contain the active ingredient - 0 + 075 g adjuvants ( eudragid RL30D, triethyl citrate, titanium dioxide, eudragid RS30D, red iron oxide, MCC, magnesium stearate ).

Syrup ambrogeksal . Syrup per 5 ml active ingredient - 0 + 015 mg Excipients ( benzoic acid, raspberry essence of citric acid monohydrate, sorbitol p-op, polyvidone, sodium cyclamate, sodium metabesulfit, water, gidroskid sodium, glycerol ).

The solution for inhalations   and intake (one milliliter) contains active substances - 7 + 5 mg Excipients ( Citric acid, methyl parahydroxybenzoate, sodium bisulfite, sodium hydroxide, purified water ).

Product form

• Round and Flat pills   (White, with rounded corners), scored on one side. Packages 20, 30, 50 and 100 units.
• White capsules   gelatin inside - white or pinkish powder. Packages 10, 20, 50 or 100 pieces.
• The clear, slightly yellow viscous syrup . In bottles of 100 or 250 ml, complete measuring spoon.
• The solution   Ambrogeksal for inhalation and ingestion - transparent, with no color. The bottle with dispenser and measuring cup 50 and 100 mg.

Pharmacological action

Expectorant. Mucolytic.

Pharmacodynamics and pharmacokinetics

Active substance - ambroksol   It refers to the group benzylamines . Restores the normal balance between serous   and mucous   component secret bronchi By increasing the secretion of mucous membrane and acts directly on the active cells in the bronchial glands. The substance stimulates the activity of the special villi airways Thus facilitating its movement on the bronchi. Ambroxol hydrochloride also tends to decrease the viscosity of sputum by depolymerization of mucopolysaccharides . Number of bronchial secretion does not increase the stimulation of the centers, causing increased cough occurs.

In the period between half an hour to three hours after oral administration of tablets, the drug reaches maximum concentration in the lungs. About 90% of the substance binds to blood proteins . Most drugs excreted by the kidneys through the 6-11 hours after ingestion in the form glucuronide   (or unmodified), the remainder is metabolized in the liver.

Indications

From what is prescribed the pill?

• bronchitis   acute or chronic;
• pneumonia ;
• bronchiectasis ;
• tracheitis ;
• bronchial asthma   (deficit of bronchial secretions);
• for prophylaxis before operations;
• pregnant women, when there is a threat of preterm birth (28-34 weeks).

Contraindications

• drug allergy   on ambroksol   and other components of the product;
• first trimester of pregnancy;
• gastric ulcer , Liver and kidney disease;
• children up to 6 years;
• Children under 12 are not recommended to receive long-acting capsules.

Side effects

• nausea, pain epigastric . dry mouth . diarrhea ;
• dryness in the nasal cavity or on the contrary excessive secretion;
• allergic reactions, including skin;
• generalized weakness . dysuria .

When applying the syrup or drops can develop specific reaction metabisulfite   ( diarrhea, shock, loss of consciousness, nausea, asthma attacks ).

Instructions for use ambrogeksal (method and dosage)

At reception tablets   the daily dose for an adult (over 12 years) in the first three days is 90 mg per day, distributed into 3 doses. Further, the dosage can be reduced to 60 mg. Children (from 6 years) appoint 30-45 mg per day.

To capsules   prolonged action the main condition is to maintain the integrity of the shell at the reception. Assign usually 75mg agents (Table 1). After meals, once a day. Not recommended for children under 12 years.

Syrup   prescribed for adults (12 years) and 30 mg (2 scoops) three times a day, the first few days. Then - the same quantity of 2 times per day. The maximum daily dose - 60 mg.

Children from 5 years - 1 teaspoon 3 times a day, from 2 to 5 - half of a spoon, about 2 years old - half a spoon 2 times a day.

According to the instructions on the ambrogeksal inhalations , Adults appoint 80 drops 3 times a day, the first day, then - 80 drops 2 times a day. Children up to 12 years - 40 drops 3 times a day, up to 5 years - 20 drops 3 times a day, up to 2 years - 20 drops 2 times a day.

Solution for oral and inhalation can be diluted in tea, juice, milk or water.

Divorce drops for inhalation?

Dilute the drug should be 0, 9% nat. solution , Equal proportions of approximately 50% to 50%. The prepared solution should be heated to 40-50 degrees. Sniffing children should for 2-3 minutes, adults - up to five minutes.

Adults (over 5 years) inhalation twice a day, diluted 50 drops.

For children under 5 years diluted 40 drops, inhalations - 2 times a day.

You should not use the drug in any of the types of more than five days without consulting a doctor or observation.

Overdose

It occurs rarely.

The most common symptoms are manifested: hypersalivation, vomiting, diarrhea, hypotension . Treatment - according to exhibited symptoms.

Cooperation

It can be combined with drugs prescribed for asthma .

Be wary of antibiotics   ( erythromycin, amoxicillin, cefuroxime ), So there is an increase in their concentration in the body.

Do not combine with Codeine   and other antitussives .

Terms of sale

The recipe is not necessary.

Storage conditions

In the closed form, dark, cool place.

Shelf life

4 years.

Analogs

Match code ATC 4th level:

• Ambroxol
• Fluifort
• Flavamed
• Fluimucil
• ACC
• Atsistein
• Mucosolvan
• Bromhexine

Abrol, ambroxol, ambronorm, bronhoval, flavamed cough Ambrosan, Mucosolvan, lazongin, ambrobene, ambrolitin, ambrosprey, ambrohem, bronhoval, lazoleks, mukosol, Maddox, pulmibrom, mukotablin, medovent .

Mucosolvan or ambrogeksal - which is better?

Both drugs contain the same active ingredient ambroxol. At about the same effectiveness and impact. Ambrogeksal cost lower than that of its counterpart Mucosolvan .

During pregnancy and lactation

During pregnancy in the first trimester intake of the drug is prohibited.

Perhaps the use of the second and third trimester, after consulting a doctor.

When breastfeeding, a sufficient amount of the active ingredient is excreted in milk, so you should consult with a specialist.

Reviews Ambrogeksale

Reviews tablets ambrogeksal good. Benefiting from a strong dry cough, it has virtually no side effects. Many consider him the dignity of the drug low cost and high availability. The syrup has about the same popularity and performance, has a pleasant sweet taste. Typically, the cough lasts for a week after the start of treatment means.

Reviews for inhalation solution - positive. A convenient form of release, high efficiency and speed of recovery - the main advantages of the drug. Many use Ambrogeksalom inhalation and saline for young children and happy with the result. The disadvantage is considered bad taste of this form of the drug.

Price (Where to buy)

Price tablets   Ambrogeksal about 84 rubles per 20 pieces.

Capsules   prolonged action will cost 120 rubles per 10 pieces.

Bottle liquid for inhalation   It costs about 92 rubles per 50 ml.

Syrup   It costs about 103 rubles per 100 ml.

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