Diclofenac

Description overdue on 29.11.2011

Related Articles:

• Figurin
• Indications for use of the drug Concor
• Rulid, instructions for use and price
• Dekatilen

Tweet

Nonsteroidal anti-inflammatory drug. Diclofenac is a derivative phenylacetic acid . The drug has a pronounced anti-inflammatory, mild sedative effect. The mechanism of action is aimed at reducing the number of prostaglandins , Infringement of metabolism arachidonic acid , Non-selective inhibition of cyclooxygenase   1 and 2. The drug affects the focus of inflammation. Due to the water-based ethanol is an additional local anesthetic effects. Diclofenac is available in the form of a gel, solution, suppository, pellet.

Indications:

Diclofenac prescribed for diseases of the musculoskeletal system in the inflammation phase chronic juvenile, psoriatic arthritis . ankylosing spondylitis , Revmoporazheniya soft tissue urarthritis . rheumatoid arthritis . The drug is effective in traumatic inflammation of the joints, muscles, ligaments, tendons. Diclofenac relieves pain: neuralgia . sciatica . lumbago , Bursitis, tenosynovitis . osteochondrosis , Myalgia, deforming osteoarthritis.

Contraindications:

Diclofenac Gel is not appointed in violation of the integrity of the skin. The drug is contraindicated in children under 6 years old, with an allergy to NSAIDs. With caution is prescribed for ulcerative lesions of the gastrointestinal tract, acute hepatic porphyria, "Aspirin" asthma , Congestive heart failure, severe liver and kidney systems, with bleeding disorders, pregnancy, breastfeeding, elderly.

Side effect:

Skin:   multiforme exudative erythema . photosensitization . eczema Contact dermatitis (vesicular, papular rash, itching, swelling, redness of the treated area). Allergic reactions : angioedema , Erythematous rash, anaphylactic shock, burning, urticaria. Long-term use of the drug diclofenac, drawing on extensive areas leads to systemic complications. Perhaps the development of bleeding, ulcers of the digestive tract, increased liver transaminases, toxic hepatitis , Dizziness, anxiety, taste perversion, diplopia , Tinnitus, nephrotic syndrome, anemia, tachycardia, leukopenia, arrhythmias, thrombocytopenia, scotoma, bronchospasm, increase in blood pressure.

Mode of application:

A solution of Diclofenac administered intramuscularly at the dose of 75 mg once a day, 1 to 5 days. At the same time taking oral dosage forms should be aware that the maximum daily dose is 150 mg. After the injections, if necessary a transition to suppositories, capsules. A tablet form of the drug is prescribed in a dose of 50-150 mg per day for 3 doses. Diclofenac candles: once daily, 100 mg. At night no more than 150 mg. Gel, ointment, 2-4 g of the drug with a thin layer on the skin over the fire of inflammation, flavorful rub massaged 3 times a day.

Special instructions:

Diclofenac gel can be applied only to intact skin. After applying the gel is recommended that the imposition occlusive dressings . Do not use the drug for a long time in large doses. It is strongly advised to avoid contact with dosage forms of the drug in the eyes or on the surface of the mucous membranes. During treatment Diclofenac should refrain from managing complex mechanisms.

Drug Interactions:

Concentration   phenytoin, digoxin   decreases while taking diclofenac. Antihypertensives, diuretics lose their effectiveness. Potassium-sparing diuretics may lead to hyperkalemia . Diclofenac increases the toxic effect cyclosporine   renal system. Acetylsalicylic acid   It lowers the level of drug in the blood. Diclofenac increases the toxic effects Methotrexate , By increasing its concentration.