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The main component is able to inhibit the activity of the virus at the early stage specific reproduction (since the intracellular penetration of the virus to the initial stage and transcription of RNA). Rimantadine increases the functional activity of natural killer cells of NK-cells - T and B lymphocytes; induces the production of interferons alpha and gamma. The active ingredient of the drug is a weak base raises the pH of endosomes, which are membrane vacuoles surrounded and intracellular virus particles after penetration.
Due to prevent acidification in these vacuoles is achieved the blocking of the merger and the viral envelope membrane of the endosome. This mechanism prevents the transfer of viral genetic material into the cell cytoplasm. The drug interrupts the process of transcription of the viral genome by inhibiting release of viral particles from the cell. Appointment of preventive daily dosage (200 mg) of the drug Rementadin to reduce the risk of influenza and reduce the severity of symptoms of influenza, serological reactions. The therapeutic effect of the drug is observed in the appointment rementadina in the first 18 hours after the first signs of the disease. Remavir available in tablet dosage form.
Indications:
Drug Usage Remavir recommends prescribers with influenza type A (prevention in children, adults, and early treatment in adults).
Contraindications:
Remavir pills not prescribed for intolerance rimantadine, breastfeeding during the period of gestation pregnancy, children up to age 1. In severe renal pathology system and liver epilepsy medication prescribed with caution.
Side effect:
The digestive tract: stomachalgia , Nausea, dry mouth, vomiting, anorexia . Central nervous system: nervousness, insomnia , Impaired concentration, headaches, fatigue, dizziness.
Mode of application:
Remavir taken after meals, the tablet must be washed down with water. Prevention of influenza: twice daily at 100 mg. For children, the dosage is calculated according to a 5 mg per 1 kg. Calculate the dose administered 1 time per day. The maximum daily dosage for children - no more than 150 mg. Treatment of influenza : The course is designed for 5-7 days of daily administration of 100 mg twice a day after the first signs of the disease. In severe renal and hepatic pathology systems Remavir administered 1 time a day at a dose of 100 mg. The therapy of influenza A is recommended to start in the first 24-48 hours after onset of symptoms, the course is designed for 5-7 days. The optimal duration of treatment has not been established.
Special instructions:
Remavir compared with amantadine has a stronger impact and is less toxic. The drug is capable of exerting anti-toxic effects of the flu caused by virus type B. Perhaps the development of the drug-resistant viruses. The drug is recommended for appointment after contact with infectious patients during a flu epidemic , The propagation of disease in closed collectives prophylactically for 10 days.
During epidemic Remavir administered daily for 6-8 weeks to develop active immunity after immunization with an inactivated vaccine. If immunization is contraindicated or the vaccine is not available, Remavir prescribed in cases of accidental or re-infection for 90 days. The drug can influence the ability to focus on driving. Reviews on Remavir show high antiviral activity of the drug when taken in the first hours after contact with infectious patients.
Drug Interactions:
Cimetidine able to reduce the clearance of the drug by 18%. Acetylsalicylic acid and reduce the maximum concentration of paracetamol active ingredient rimantadine 10 and 11% respectively.
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