Zyvox

Description overdue on 02/26/2013

Related Articles:

• Antibiotic Amosin
• Vitamins Vitrum
• Price Clexane
• Levamisole

Tweet

Antimicrobials.   The main component -   linezolid . The principle is based on the exposure process of suppressing protein synthesis in the microbial cell by binding to bacterial ribosomes and stop the formation of an initiating functional complex 70S, which is an important component in translation during protein synthesis. In vitro drug is active against some anaerobic Gram-negative and all Gram-positive aerobic bacteria . By the effects of the drug Zyvox sensitive enterococci korinobakterii, Listeria, staphylococci , Streptococcus, chlamydia, legionella, mycoplasma . Cross-resistance between the drug and other antimicrobial drugs (lincosamides, glycopeptides, beta-lactam antibiotics, aminoglycosides , Tetracyclines, rifamycins, chloramphenicol) not selected. Thanks to multi mutations 23S ribosomal RNA of microorganisms resistant to the effects of linezolid develops slowly. Zyvox is produced as a solution, granules and a tablet dosage form.

Indications:

Instructions for use of the drug Zyvox recommends the use of medicines enterococcal infections , Pneumonia (hospital and community-acquired forms), infectious lesions of the soft tissues of the skin.

Contraindications:

Zyvox is not applicable in case of intolerance linezolid. When carrying a pregnancy and breastfeeding medication prescribed with caution.

Side effect:

Zyvox can cause allergic reactions, candidiasis, headache, flatulence, hyperbilirubinemia , Thrombocytopenia, anemia, nausea, diarrhea, epigastric pain, nausea, disturbances of taste perception.

Mode of application:

Zyvox intravenously administered for 30-120 minutes of infusion. After parentelnogo administering to the patient can be transferred to any other form of antimicrobial drugs (no correction mode thanks to the 100% bioavailability while taking the drug orally).   When enterococcal infections Zyvox is prescribed twice daily 600 mg either inside or intravenously, the course is designed to endure 14-28 days. When pneumonia   Linezolid is taken orally twice daily 600 mg (possibly by intravenous infusion), the duration of treatment 10-14 days. The maximum permitted daily dose - 1, 2 grams.

Special instructions:

Therapy with Zyvox necessarily require a dynamic observation of blood counts (especially - platelets) in patients with anemia , An increased risk of bleeding with thrombocytopenia . The development of diarrheal syndrome during treatment with linezolid may indicate the formation of pseudomembranous colitis. Zyvox price varies depending on the pharmacy chain (the average price is 500 rubles).

Drug Interactions:

Zyvox pharmaceutically compatible Ringer's solution, dextrose, sodium chloride. Absolutely incompatible registered with diazepam, amphotericin B, erythromycin , Hloropromazinom, ceftriaxone sodium, co-trimoxazole, phenytoin, pentamidine isethionate. Pharmacodynamic interactions: Zyvox can cause reversible, moderately pronounced increase in the pressor effect and phenylpropanolamine pseudoephedrine   (In the form that the medicament is a non-selective MAO inhibitor reverse action). If necessary, concurrent therapy adrenergic agents   (dopamine agonists) is recommended to reduce their initial dosage required to conduct titration.