Norkolut

Description overdue on 06/27/2014

• Latin name: Norcolut
• ATC code: G03DC02
• Active substance: Norethisterone (Norethisterone)
• Manufacturer: Gedeon Richter, Hungary

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Norkoluta (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

1 tablet contains norethisterone   5 mg. Additional ingredients are magnesium stearate, gelatine, colloidal silica, potato starch, talc, lactose monohydrate, corn starch.

Product form

Tablets of white color, 20 pc. packaged.

Pharmacological action

It refers to a group progestogens . It promotes transformation of the endometrium from proliferative phase to secretory. Ways to prevent the development of the pituitary gland gonadotropin . Blocks follicle maturation and ovulation.

Pharmacodynamics and pharmacokinetics

Bioavailability is 77%. The maximum serum concentration is achieved within 4 hours. Displays in the form of metabolites kidneys (by conjugation with glucuronic acid), and through the intestines. The half-life of about 8 hours.

Indications

From what Norkolut pills?

The drug is used for:

• dysmenorrhea ;
• premenstrual syndrome ;
• endometriosis ;
• uterine bleeding   anovulatory character;
• hyperplastic processes in the endometrium;
• mastodynia ;
• uterine cancer ;
• to prevent or stop Lactation ;
• progesterone for a diagnostic test.

Contraindications

• pregnancy ;
• breast tumor malignancy;
• cancer of the female reproductive organs;
• disease and liver tumors;
• jaundice ;
• increased content bilirubin   in blood;
• kidney disease with impaired;
• thromboembolism   and sharp thrombophlebitis ;
• predisposition to thrombosis ;
• genitourinary bleeding of unknown nature;
• obesity ;
• puberty ;
• brought cholestasia pregnant ;
• herpes ;
• idiosyncrasy.

Assign cautious when:

• hypertension ;
• epilepsy ;
• asthma ;
• renal failure ;
• migraine ;
• Heart Failure ;
• convulsive disorders, and CNS pathology;
• hyperlipidemia ;
• diabetes ;
• thromboembolism   and   thrombophlebitis   history.

Side effects

• breast tenderness;
• dyspepsia ;
• headache ;
• acyclic bloody discharge from the vagina type;
• fatigue;
• weight gain;
• paresthesia ;
• rashes and itching;
• edema peripheral tissues.

Side effects thromboembolism   and thrombosis   develop with prolonged use.

Instructions for use Norkoluta (method and dosage)

How and why prescribed Norkolut?

The drug is used for schemes:

• at endometrial hyperplasia   and for the treatment of anovulatory uterine bleeding   - Up to 10 mg per day. Upon the occurrence of the desired effect are used from 16 to 25 day cycle in combination with estrogen ;
• at endometriosis   use one tablet is 5 to 25 day cycle;
• use for the treatment mastodynia , Premenstrual syndrome and dysmenorrhea   provides reception with estrogen 1-2 tablets from 16 to 25 th day;
• uterine fibroids   treated for 6 months with intake of 5-10 mg 5-day cycle of 25 minutes;
• Call for monthly take 5 days to 2 tablets after receiving occur monthly.

Instructions on Norkolut provides a clear framework for cessation of dosing Lactation   - Prescribe acceptance for 10 days, starting with a dose of 20 mg, which is gradually reduced by 5 mg every 3 days, reaching a final dose of 1 tablet.

To prevent interruption during lactation pregnancy   up to 28 weeks for the first day of taking 15 mg, in 2-3 days - 2 tablets and 4 through Day 7 - 5 mg per day. If the abortion took place in the period from 28 to 36 weeks starting from 15 mg to 2-day take 10 mg.

Overdose

Symptoms include vaginal bleeding . dyspepsia   in the form of nausea and vomiting. For the treatment of symptomatic treatment is used.

Cooperation

Metabolism norethisterone   It may be aggravated by simultaneous reception with inducers of liver enzymes.

Apply carefully in conjunction with anticoagulants , Means for lowering the level of glucose in the blood and Corticosteroid .

Do not prescribed in conjunction with cimetidine . phenytoin . barbiturates   and rifampicin .

Terms of sale

Prescription.

Storage conditions

In sheltered from children, to observe temperature range of 15 - 30 ° C.

Shelf life

5 years.

Cautions

Before the course of treatment to exclude malignancy and conduct a survey of genital and breast cancer.

Analogs Norkoluta

Primolyut Nord . Orgametril . Pregnin .

One popular peers on the testimony of a Djufaston .

Djufaston or Norkolut - which is better?

Both drugs differ in the active substance, but similar indications. Djufaston additionally used for treatment infertility Threats abortion   and habitual abortion . Also this drug is more modern than Norkolut, but its price is higher.

Available at the reviews on Norkolut endometrial hyperplasia They say that the treatment of this disease it is better Duphaston . In any case, it is necessary to listen to the recommendations of experienced professionals, since the choice of drug depends on the individual characteristics and diagnosis.

Synonyms

Primolyut Nord . Orgametril .   Pregnin.

Babies

Do not use this at puberty.

With alcohol

Precise data on the incompatibility alcohol   with no drug. However, we must remember that Norkolut exposed metabolized in the liver, so excessive load on this body, which has an alcohol may adversely affect the body during treatment.

During pregnancy and lactation

Pregnancy is not an indication for the use of the drug. In the postpartum period the drug reduces the production of milk.

Reviews Norkolute

Each women's forum contains a lot of reviews on the use of hormonal drugs for the treatment of gynecological diseases. Norkolut widely used in the endometriosis . From the experience of women apply it is known that the drug performs in this case, a good effect - reduces the intensity and duration of the bleeding.

The tablets are used in case of violation of the menstrual cycle for the call period. Already on the 6th day of application achieved the desired result.

Available at the reviews on Norkolut myoma   are not sufficient to judge the effectiveness of this pathology, but a few women wrote that the drug is delayed further growth of fibroids.

Doctors about Norkolute mixed. Every doctor has their own preferences in the choice of the drug, but the drug is enough popular in the medical environment. The tablets used in the ovarian cyst - often with follicular   or endometrioid formations, thus yielding positive results.

Of the major drawbacks of the agents referred to weight gain and mood changes.

Price Norkoluta where to buy

Norkoluta average price in Russia is 120 rubles. per pack of 20 tablets.

In Ukraine, the drug can be bought for 77 UAH.

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