Description overdue on 05/27/2014
- Latin name: Calcium + Vitamin D3 Vitrum
- ATC code: A12AX
- Active substance: Calcium Carbonate (Calcium Carbonate), Kolekaltsiferol (Colecalciferol)
- Manufacturer: UNIPHARM, Inc., USA
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on the Vitrum Calcium + vitamin D3
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The composition of one tablet Vitrum Calcium with Vitamin D3:
- Kolekaltsiferol (vitamin D3) - 5 mcg;
- calcium carbonate - 1.25 g.
Excipients: magnesium stearate, silicon dioxide, croscarmellose sodium, microcrystalline cellulose, triacetin, riboflavin, hypromellose, titanium dioxide, brilliant blue dye.
Product form
Vitrum Calcium with vitamin D3 is produced in the form of oval tablets in a light green color.
30, 60 or 100 of these tablets in a plastic bottle, a vial in a carton box.
Pharmacological action
Regulating metabolism Calcium and Phosphorus . The drug replenishes Calcium and Vitamin D3 in the body, is involved in mineralization of the teeth. Cooperation Vitamin D3 and Calcium inhibits increased production Parathyroid hormone (promotes decalcification of bones ).
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Calcium carbonate - The substance compensates for the deficiency Calcium . This is a necessary component in the process of bone formation, blood clotting, nerve conduction and muscle contraction, the mineralization of teeth, providing a stable nervous system.
Kolekaltsiferol (vitamin D3) controls metabolism Phosphorus and Calcium in the body, prevents the development of rickets It contributes to the normal course of growth of the teeth and skeleton, providing a constant concentration of these substances in bone. Vitamin D3 enhances the absorption Calcium in the intestines and reduce the loss Phosphates through the kidneys - because the process of regulation of metabolism. Increase adsorption Calcium in the digestive tract it is due to stimulation of the biosynthesis calcium-binding protein kolekaltsiferola and increasing the permeability of cell membranes of the intestinal epithelium. Vitamin D3 also strengthens the converse the absorption of Phosphates during filtration in the kidneys and regulates ion content Calcium in bone tissue, plasma the blood and soft tissues. As a result, the tone of skeletal muscles is supported, and infarction heart.
Kolekaltsiferol It is also required for proper functioning parathyroid glands and forming immunity .
Pharmacokinetics
The drug is absorbed in the small intestine. In the blood, active substances form bonds with plasma proteins, however, some of the Calcium It is circulating in the bloodstream in the form of ions. Their content in the blood is approximately 1, 1-1, 2 mmol / l.
Kolekaltsiferol is metabolized in the kidneys and liver, resulting in formation of a pharmacologically active metabolites, the effects of which are identical to the effects of Vitamin D3 . Half-life kolekaltsiferola It occurs throughout the day.
Calcium as ion excreted in the urine, with its partial reabsorption in the kidney.
Indications
- Need to fill shortage Vitamin D3 and / or Calcium while rapid growth in youth and adolescence, women during pregnancy and lactation.
- Prophylaxis and therapy osteoporosis (steroid, menopausal, senile, idiopathic and other species), and its complications (bone fractures).
- Deficiency Vitamin D3 and calcium in the elderly.
Contraindications
- Allergies to the drug and its components.
- Hypercalcemia Including at hyperfunction parathyroid glands .
- Increased concentration Calcium in urine.
- Urolithiasis disease . sarcoidosis and severe renal impairment.
- Cancers with metastases in bone.
- Children under 8 years old.
It should be used with caution to persons with renal insufficiency, and children age 8-12 years (maximum dose for this age group - 1 tablet per day).
Side effects
- On the part of metabolism: hypercalcemia, hypercalciuria.
- From the digestive system: flatulence , stomach ache, constipation , Nausea, diarrhea .
- On the side immunity : allergic reactions Including hives . rash and itching.
Instructions on Vitrum Calcium + Vitamin D3
The drug is taken orally, the tablet must be swallowed without chewing. To achieve the best therapeutic effect is recommended to organize a reception before a meal or during a meal.
Adults and children aged 12 years and older, pregnant and lactating women are recommended 1 tablet once or twice a day.
Adults and children aged 12 years and older for the treatment of osteoporosis selected individually dose (maximum dose should not exceed 4 tablets per day) for the prevention of osteoporosis is recommended 1 tablet twice a day.
Overdose
Use of the drug in high doses can cause abnormalities in the cardiovascular and excretory systems, as well as vomiting, nausea, headaches and general weakness.
Treatment of overdose: gastric lavage, drinking alkaline liquid, the diet with the lowered maintenance Calcium , Severe cases require the introduction of corticosteroids .
Cooperation
Barbiturates and phenytoin inhibit the action Vitamin D3 .
Vitrum Calcium with vitamin D3 increases efficiency cardiac glycosides .
The drug is a joint application inhibits absorption salicylates, tetracyclines, sulfonamides, indirect anticoagulants and beta-blockers .
Taking the drug with thiazide diuretics may result in the development of hypercalcemia .
Terms of sale
This medicine is available without prescription.
Storage conditions
Keep away from children. Store in a dry, dark place at a temperature below 30 degrees.
Shelf life
3 years.
Cautions
During the period of administration of the drug is recommended to control the allocation of Calcium urine and its content in the blood (if the performance of calcium above 7.5 mmol per day, it is necessary to reduce the dose or stop taking the drug).
It is forbidden to use Vitrum Calcium with vitamin D3 along with other vitamin complexes having the same active ingredients.
Analogs
Analogues of drugs are Vitiron Osteo . Vitrum Osteomag . Vitrum Calcium 600 + D400 . Calcium-Osteovit .
Babies
Not recommended intake for children up to 8 years.
During pregnancy and lactation
The use of this drug during pregnancy and lactation should be coordinated with the attending physician. The maximum dose of the drug during this period - 3 tablets per day.
Reviews of Vitrum Calcium + D3
Reviews for Vitrum calcium evidence of efficacy in the prevention and treatment of osteoporosis and bone fractures.
Price Vitrum Calcium + D3
Price Vitrum Calcium with Vitamin D3 (30 tablets dosage) in Russia is 215-244 rubles, Ukraine - an average of 60 hryvnia.
No comments:
Post a Comment