Ofloxacin

Description overdue on 14-01-2012

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Antibiotic. Designed by first-generation fluoroquinolone . Ofloxacin is active against a broad spectrum of bacteria, it may be applied as an alternative antimicrobial agents to which the microorganisms are resistant. The drug is absorbed in the digestive tract almost completely penetrates quickly into the affected tissue, accumulating the highest possible concentration of active substance is in the affected area, which emphasizes the focused action. The half-life of 5-7 hours. Produced in tablet form at 200 and 400 mg, in a solution for injection, ointment for eyes.

Indications:

Ofloxacin is used in infectious diseases of the respiratory system, pelvic and abdomen, upper respiratory tract, skin diseases, and inflammatory soft tissue, the renal system, in combination therapy TB STI ( chlamydial infections , Gonorrhea), in the prevention of infectious diseases in patients with immunocompromised .

Contraindications:

Ofloxacin is not indicated during breastfeeding, pregnancy, intolerance of fluoroquinolones. The drug is contraindicated in diseases of the nervous system ( epilepsy The consequences of TBI, stroke Inflammatory diseases). Children and teenagers up to the age antibacterial drug is given only in the absence of the possibility of using other drugs, and taking into account the severity, characteristics of the disease.

Side effect:

Ofloxacin is in a population of well tolerated dosages and in compliance with the physician. Rare allergic complications, swelling of the face, swelling of the vocal cords, bronchospasm . There is a decrease in appetite, disorders of the digestive tract (nausea, epigatsralnye pain, vomiting, pseudomembranous colitis . diarrhea ); sleep disorders, dizziness, headaches, anxiety, agitation or general depression of consciousness, various phobias, tremors, loss of coordination; changes in the blood picture. Occasionally there is disruption of the sense of smell and taste, hepatitis.

Mode of application:

Ofloxacin is used intravenously, orally, topically. The dosage administered depends upon the severity of the disease, the level of sensitivity of microorganisms to an active substance preparation, the patient's condition. For intravenous use, the dose ranges from 100 to 200 mg 1-2 times during the day, in more severe infection may increase the maximum dose of 800 mg / day. The course of treatment by intravenous administration of 7 to 10 days. When taken orally, the drug dose is selected taking into account the above-mentioned characteristics of the patient's condition. Treatment of gonorrhea   held the appointment of a single dose of the drug at a dose of 400 mg. Keep in mind the functional state of the kidneys and liver of the patient, since the pathology of the drug accumulates in the body that requires two dosage reduction. A tablet form of the drug appropriate to take as a whole before eating, drinking plenty of water. The minimum period of treatment 3 days after the disappearance of symptoms and normalization of the patient's temperature.

Special instructions:

During the period of drug administration Ofloxacin should not engage in types of work that require concentration and speed of reaction, including driving a car. In applying the "ofloxacin" should limit exposure to the sun, as the increased sensitivity of the skin to UV radiation.

Drug Interactions:

Antacids Containing iron salts, aluminum reduce the absorption of the drug Ofloxacin. The recommended interval between meals - not less than 2-hours. Caution should be taken with theophylline , Preparations of vitamin K antagonists, citrates , Nonsteroidal anti-inflammatory drugs and glucocorticosteroids , Carbonic anhydrase inhibitors, sodium bicarbonate.