Description overdue on 05/15/2014
- Latin name: Theraflex Advance
- ATC code: M01AE51
- Active substance: Chondroitin sulfate (Chondroitini sulfas), Glucosamine (Glucosamine) and Ibuprofen (Ibuprofen)
- Manufacturer: Sagmel, USA
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Teraflex Advanced (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 capsule formulation is composed of: glucosamine sulfate 250 mg chondroitin sulfate 200 mg Ibuprofen 100 mg; additional ingredients: corn starch, cellulose, sodium carboxymethyl starch, stearic acid, crospovidone , Silicon dioxide, magnesium stearate, povidone.
As part of the gelatin capsules: gelatin, titanium dioxide, dye blue.
Product form
Gelatine capsules, with a blue cap and white body, inside - white powder. Capsules of 30, 60 or 100 pieces. in plastic bottles.
Pharmacological action
It stimulates cartilage repair and reduces inflammation.
- Chondroitin sulfate - A substance involved in the formation of healthy cartilage. This maintains the viscosity of synovial fluid, inhibits enzymes that break down cartilage. In osteoarthritis reduce the symptoms of the disease and helps to reduce the doses of NSAIDs.
- Glucosamine sulfate It improves the synthesis of substances which are the main components of cartilage, membranes and synovial joint fluid.
- Ibuprofen It provides anti-inflammatory effect, relieves pain, has antipyretic effect due to blockade cyclooxygenase - 1 and cyclooxygenase - 2 .
Glucosamine and Chondroitin increase the analgesic effect ibuprofen .
Pharmacodynamics and pharmacokinetics
Bioavailability glucosamine - About 25%, with the biggest concentration of the substance is in the cartilage of the joints, liver and kidneys, the highest concentration is found in liver, kidney and the articular cartilage. Almost 30% of the substance is entered in the muscles and bones for quite a long time. The half-life - about 3 days, excreted in the urine.
Bioavailability Chondroitin sulfate After absorption in the gastrointestinal tract is approximately 13%.
The maximum concentration occurs within 4 hours of blood, and in the synovial fluid - within 5 hours. A large number contained in the synovial fluid. Because the organism is excreted in urine.
Once inside ibuprofen its maximum concentration occurs within 1 hour. Capable of up to 99% of binding to plasma proteins and penetrates into synovial fluid. It is metabolized in the liver and excreted by the kidneys. The half-life of about 3 hours.
Indications
- osteochondrosis with moderate pain;
- osteoarthritis large joints.
Contraindications
- ulcerative lesions of the gastrointestinal tract ( stomach ulcer . Crohn's disease , Ulcerative colitis);
- gastrointestinal bleeding;
- intracranial hemorrhage;
- bleeding disorders;
- Aspirin asthma ;
- bleeding diathesis ;
- children up to 12 years;
- idiosyncrasy constituent components of the drug;
- pregnancy and breastfeeding;
- Hypersensitivity to aspirin and NSAIDs.
Assign caution in hypertension, congestive heart failure, severe lesions of the kidney and liver, gastrointestinal diseases, hyperbilirubinemia, nephrotic syndrome, blood diseases, diabetes . asthma In elderly patients.
In case of intolerance to seafood increases the likelihood of developing an allergy to the drug.
Side effects
There may be nausea, diarrhea , Abdominal pain, bloating, constipation, and allergic reactions. In the case of drug withdrawal side effects disappear.
The majority of adverse reactions to occur Ibuprofen Which is part of the preparation.
- Digestive system : Dry mouth, stomatitis, abdominal pain, heartburn, nausea and vomiting, bloating, constipation and diarrhea, pancreatitis and hepatitis.
- Respiratory system : bronchospasm and shortness of breath.
- CNS : Dizziness, headache, irritability, insomnia, drowsiness, depression, hallucinations and confusion.
- Senses : Changes in hearing (noise or ringing in the ears, hearing loss), dry eyes, double vision, swelling of the eyelids and conjunctiva.
- Heart and blood vessels : Heart palpitations, increased blood pressure, heart failure.
- The urinary system : nephrotic syndrome . cystitis . jade , Acute renal failure.
- Hematopoietic system : thrombocytopenia . anemia . leukopenia , Thrombocytopenic purpura, increased duration of bleeding.
- Allergic reactions : erythematous rash , Itching, hives, anaphylactic shock . angioedema , Bronchospasm, exudative erythema multiforme, Lyell's syndrome, allergic rhinitis, eosinophilia.
Instructions for use Teraflex Advanced (method and dosage)
Take three times a day for 2 capsules after meals, washed down with water in a small amount.
Guide to Advanced Teraflex recommends that the treatment is not more than 3 weeks without consulting a specialist.
Overdose
Symptoms are mainly related to ibuprofen : Abdominal pain, nausea, headache, vomiting, hypotension, drowsiness, confusion, tinnitus, renal failure, metabolic acidosis , Rapid or slow heartbeat.
For treatment use gastric lavage, Activated carbon , Alkaline water, symptomatic therapy.
Cooperation
Ethanol . tricyclic antidepressants . rifampicin . barbiturates at a joint reception to increase the risk of liver damage.
Advanced Teraflex able to reduce the effect of antihypertensive drugs (ACE inhibitors and calcium channel blockers) furosemide . hydrochlorothiazide and uricosuric agents.
The drug enhances the effects of antiplatelet agents . anticoagulants and fibrinolitikov Thereby increasing the risk of bleeding.
Potentiates the side effects of drugs that have ulcerogenic action - NSAIDs, ethanol, estrogen, corticosteroids.
Preparations antacid action reduce the absorption of ibuprofen .
Teraflex Advanced enhances the effect of insulin and other hypoglycemic drugs, increases the blood concentration of cardiac glycosides, methotrexate and lithium - containing preparations.
The analgesic effect of the drug may increase caffeine .
Ibuprofen anti-inflammatory and reduces the antiplatelet effect of aspirin.
Cefoperazone . tsefamandol . valproic acid . plicamycin . tsefotetan increase the risk of hypoprothrombinemia.
The combined use of myelotoxicity drugs enhance the toxic effect on the blood system.
Admission to the drugs cyclosporine and gold increase nephrotoxicity and hepatotoxity .
Glucosamine It can reduce the effect of doxorubicin , Hypoglycemic drugs, teniposide . chloramphenicol , Semi-synthetic penicillins and tetracyclines increase absorption.
Terms of sale
Over the counter.
Storage conditions
Away from children at a temperature not exceeding 25 ° C.
Shelf life
2 years.
Cautions
If necessary, long-term use of the drug required monitoring of blood parameters and functions of the kidneys and liver.
In the case of the onset of symptoms gastropathy necessary examination to exclude the formation of ulcers and bleeding.
In the case of the need for other analgesics and NSAIDs should be aware of the part of the drug ibuprofen .
Analogs Teraflex Advance
Full no analogues in Russia. The only possible use chondroprotectors ( Chondroxide . Struktum . Mukosat . Artra . Hondroglyuksid . Hondrofleks ) In conjunction with NSAIDs to achieve an effect similar Teraflex Advanced.
What is the difference Teraflex and Teraflex Advanced?
Advanced Teraflex further with ibuprofen .
Babies
Is contraindicated in children under 12 years.
During pregnancy and lactation
The application is contraindicated.
Reviews of Advanced Teraflex
Patients speak about the drug as a means of having the effect in the case of prolonged use. The disadvantage is the presence of side effects from the gastrointestinal tract in the form of stomach pains and aggravations gastritis and ulcers .
Reviews of doctors who use Advanced Teraflex in their practice, are ease of use for the treatment of lesions of the joints - in one capsule has both NSAIDs and substances that restore cartilage.
Price Teraflex Advanced, where to buy
Advanced Teraflex Price ranges from 406 rubles. 30 capsules to 1464 rubles. 120 capsules. In Ukraine, the cost of the drug an average of about 373 UAH. 120 capsules.
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