Kardionat

Description overdue on 09/10/2014

• Latin name: Cardionate
• ATC code: C01EB
• Active substance: Meldonium (Meldonium)
• Manufacturer: Makiz Pharma, Russia

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Kardionata
• Contraindications
• Side effects
• Instructions for use Kardionata (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Solution for injection

1 ampoule (5 ml) contains 500 mg dihydrate meldonium   - Active substance.

Auxiliary ingredients:

• water for injections.

Capsules

1 capsule contains 250 mg or 500 mg dihydrate Meldonium   - Active substance.

Auxiliary ingredients:

• potato starch;
• colloidal silica;
• calcium stearate.

Product form

The drug Kardionat produced in two pharmaceutical forms:

• hard gelatine capsules of 20, 40 or 100 units in one package;
• Injection - 5 or 10 vials of 5 ml in a single package.

Pharmacological action

Cardioprotective, metabolic.

Pharmacodynamics and pharmacokinetics

Kardionat is a synthetic analogue of gamma-butyrobetaine, and therefore inhibits gamma butirobetaingidroksilazu lowers replication carnitine   and transport of fatty acids (long-chain) through the cell membranes in the cells inhibits the accumulation of activated fatty acids   in the non-oxidized state (A and derivatives atsilkofermenta acylcarnitine).

Meldonium   It has cardioprotective properties, normalizes myocardial metabolism . When ischemia is actively involved in the restoration of the balance between the processes of supplying oxygen to the cells and intracellular consumption, prevents the breakdown in the transport of ATP. At the same time, it activates glycolysis .   passing oxygen at no extra cost. Due to the low content of carnitine synthesis of gamma-butyrobetaine is held at a heightened pace, and therefore, manifests a pronounced vasodilating effect.

The mechanism of action Kardionata determines the multiplicity of its therapeutic effects, including: increase efficiency, decrease symptoms of physical and mental overstrain, cardioprotective effects, activation of humoral immunity and tissue.   In acute myocardial ischemia   inhibits the development of   necrotic zone It reduces the rehabilitation period.

With Heart Failure (CH) increases myocardial contractility .   significantly increases the ability to exercise and their duration, reduces the frequency of possible angina attacks.

With irregularities in the cerebral circulation chronic and acute ischemic nature, a positive effect on blood circulation in the site of the lesion, as well as regulate it in the direction of redistribution ischemic area.

Kardionat effective in cases of vascular and degenerative changes in the fundus and toning effect on the CNS . Takes part in the elimination of functional disorders autonomic and somatic nervous systems   in patients who suffer chronic alcoholism Particularly during withdrawal.

Following oral administration, rapidly absorbed from the gastrointestinal tract.

Reaches Cmax plasma levels within 1-2 hours after application.

The bioavailability of approximately 78%.

Metabolism takes place with the formation of 2 major drug metabolites that are excreted in the urine.

When taken orally, T1 / 2 is dependent on the dose and is from 3 to 6 hours.

Indications Kardionata

Indications Kardionata capsules and injection solution:

• reduced working capacity of the patient;
• physical stress,   including people professionally involved in sports;
• accelerated rehabilitation in the postoperative period;
• CHF (congestive heart failure) together with the specific medication, kardialgiya because dystrophy (dyshormonal) infarction, ischemic heart disease (angina);
• abstinence symptom   (in combination with a specific treatment);
• cerebrovascular insufficiency;
• stroke.

Also Kardionat as a solution for injection administered:

• at acute circulatory disorders of the retina;
• at hemorrhages in the retina   (for various reasons);
• at thrombosis of the central and peripheral retinal vein;
• at   retinopathy   of different nature, including hypertensive and diabetic   (input only parabulbarno ).

Contraindications

• hypersensitivity Meldonium   or other components of the drug;
• diagnosed increased intracranial pressure   ( intracranial tumor, a violation of the venous outflow );
• patient age of 18 years (due to unknown efficacy and safety);
• lactation   and pregnancy .

In the pathology of the liver and / or kidney Kardionat administered with extreme caution.

Side effects

During the therapy with Kardionata side effects occur very rarely and mostly manifest allergic reactions (rash, redness, swelling, itching) , and tachycardia, dyspeptic disorders, arousal and lowering blood pressure.

Instructions for use Kardionata (method and dosage)

Capsule

Capsules Kardionat drug taken orally (inside), swallowing whole (without chewing or section) and drinking water.

Admission is better to carry the capsules in the morning, as there is a possibility of the exciting effect.

With stable angina   Kardionat taken 1-2 times daily in a dose of 250 mg - 500 mg, in the first 3 to 4-day therapy. Further, the drug is carried out two times in 7 days, with a course of treatment for 30 to 45 days.

With cardialgia because dyshormonal dystrophy infarction recommended daily dose is equal to 250 mg, with a course of treatment - 12 days.

With irregularities in the process of cerebral circulation   chronicity recommend Kardionata 500 mg per day for 14-21 days.

With alcoholism   take 500 mg four times a day, with course of treatment - 7-10 days.

With physical overexertion and reduced performance   (including athletes) administered to adult patients at 250 mg - 500 mg in 1-2 daily administration. Therapy takes 10-14 days. In case of need, a second course of treatment can be carried out in 2-3 weeks.

Recommend professional athletes before training, receiving 250 mg - 500 mg of the drug per day. During the preparatory period of training the duration of the reception - 14-21 days, during the competition - 10-14 days.

For solution for injection

Injections Kardionata, instructions for use recommends: intramuscularly, retrobulbarly, intravenously subconjunctivally.

When excessive physical and mental stress   1 performed well intravenous injection a day at a dose of 1000 mg for 10 days to 2 weeks. Repeat courses possible in 2-3 weeks.

If you have problems in the system cerebral circulation   Intravenous injection is carried out, in the acute phase, for 7-10 days at a daily dose - 500 mg, and then move on to receive capsules.

With Cardiovascular disease (in the complex treatment) recommend intravenous administration of 500 mg - 1000 mg of solution, with a course of treatment - 10-14 days.

With chronic circulatory failure, brain   Kardionat administered intramuscularly at a daily dose - 500 mg. The course of treatment lasts - 10-14 days, and then move on to receive capsules.

With alcoholism 2 is carried out daily by intravenous injection of 500 mg, the treatment is continued for 7-10 days.

With macular degeneration and vascular pathologies of the ocular fundus carry subconjunctival and retrobulbar administering the drug at a dose of 50 mg. The course of therapy is usually 10 days.

Overdose

Since studies have shown low toxicity and low probability Kardionata of hazardous side effects, overdoses, when used, it was not observed.

Cooperation

Meldonium   can enhance the effects of vasodilatig drugs, cardiac glycosides And some antihypertensive drugs.

The simultaneous use of a Kardionata anticoagulants, antianginal drugs, antiplatelet agents, diuretics, antiarrhythmic drugs and bronchodilators.

Because of the possible manifestations tachycardia , and hypotension   Care must be taken when combining the use of a alpha-blockers, Nitroglycerin . Nifedipine, peripheral vasodilators and antihypertensives.

Terms of sale

Prescription.

Storage conditions

The temperature is not above 25 ° C.

Shelf life

Capsules -36 months.

The vials - 24 months.

Cautions

Prolonged treatment Kardionatom, patients with chronic liver disease and kidney failure, caution should be exercised.

Analogs Kardionata

Match code ATC 4th level:

• Metamax
• Tivortin Aspartate
• Deprenorm MB
• Dibikor
• Mexicor
• Sulfokamfokain
• Qudesan
• Vero Trimetazidine
• Preductal

Below are the best known analogues Kardionata that can replace the medicament:

• Hawthorn;
• Angiozyme;
• Dibikor;
• Coraxan;
• Medarum;
• Riboxinum;
• Taufon;
• Trimetazidine   etc.

Synonyms

• Vazomag;
• Mildronat;
• Meldonium   etc.

Babies

Due to the lack of reliable data on the impact of Kardionata on pediatric patients, the drug is not prescribed to patients under 18 years.

During pregnancy (and lactation)

Do not use Kardionata proven safe throughout pregnancy. In order to avoid possible negative effects on the fetus, in this period of preparation is not appointed.

Reliable information on the allocation of Meldonium and its metabolites in the mother's milk is not. If there is a need for a nursing mother is Kardionata, then the period of treatment, breast-feeding is stopped.

Reviews Kardionate

Doctors about Kardionate positioning the drug as an inexpensive and effective drug to sustain the body at a high level. Good results were found, and its use in the composition comprehensive treatment of heart failure, coronary artery disease As well as the recovery period after suffering stroke.

Reviews Kardionate forums only confirm the findings of the doctors, a special place in the positive feedback takes high efficacy in withdrawal syndrome.

Price Kardionata where to buy

The average price in pharmacies Kardionata Russia is:

• in the form of capsules 250 mg №40 - 200 rubles;
• in the form of an injection of 100 mg / ml, 5 ml №10 - 220 rubles.

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