Description overdue on 09/16/2014
- Latin name: Lornoxicam
- ATC code: M01AC05
- Active substance: Lornoxicam (Lornoxicam)
- Manufacturer: Nycomed Austria (Austria)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use of lornoxicam (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Reviews
- Price, where to buy
Composition
The main ingredient of the drug - lornoxicam .
Synonyms lornoxicam - Ksefokam and Rapid Ksefokam - Tablets contain adjuvants such as lactose, magnesium stearate, cellulose, hypromellose, croscarmellose sodium, polyvidone K25, talc and titanium dioxide.
Product form
Synonyms lornoxicam - Ksefokam and Rapid Ksefokam - Available in the form of coated tablets contained in the blister pack, as well as a powder for injection with the solvent in the kit.
Pharmacological action
The drug has anti-inflammatory . antirheumatic and analgesic effect .
Pharmacodynamics and pharmacokinetics
Lornoxicam inhibits cyclooxygenase , Acts on the gastric mucosa, and renal blood flow platelets . In addition, it reduces NG products and leukotrienes It hinders the release of reactive oxygen species, inhibits kinin system . The drug affects a greater extent on the proliferative and exudative phase of inflammation.
If ingestion lornoxicam quickly split. The bioavailability of drugs is close to 100%. The maximum concentration is achieved after about 2 hours (intramuscular administration - after 15 minutes). The high degree of connection with plasma proteins. The liver is converted into inactive metabolites . The half - about 4 hours. Approximately 30% of the drug is excreted in the urine mainly as metabolites The remaining 70% - in the bile.
Indications
The drug is used for arthritis . reactive synovitis in a Programme deforming osteoarthritis . radicular syndrome at osteochondrosis As well as for menstrual, post-surgical, dental and post-traumatic pain.
Moreover, it is administered to patients with systemic lupus erythematosus (without kidney damage) Bechterew's disease . sciatica .
Contraindications
Lornoxicam should not be taken in case of hypersensitivity to the drug, stomach ulcer and duodenal inflammatory bowel disease, thrombocytopenia . Congestive heart failure . pregnancy . Lactation , Acute bleeding from the gastrointestinal tract, prostaglandin asthma . leukopenia , Disorders of the liver and kidneys, severe hypertension .
In addition, the drug can not be taken in children (under 18 years) and the elderly.
Side effects
When using the drug may be flatulence , Nausea, abdominal pain, dry mouth, nosebleeds, gastritis . dysuria . erosive and ulcerative lesions of the gastrointestinal mucosa . acute renal failure . papillary necrosis . dizziness . depression . tachycardia . peripheral edema . leukopenia . aseptic meningitis .
Furthermore, there may be vomiting, heartburn . diarrhea , Decreased appetite, esophagitis , Bleeding from the gastrointestinal tract, the liver, arterial hypertension , Reduction glomerular filtration rate , Sodium and water retention, interstitial nephritis , Trembling, headache . Sweating . drowsiness . thrombocytopenia , Skin rashes.
By applying the solution for injection at the injection site - hyperemia , Painful.
Instructions for use of lornoxicam (method and dosage)
Instructions on Lornoxicam provides the following dosages:
- pills inside - administered 4 mg 2-3 times / day or 8 mg 2 times / day;
- the use of the intravenous solution - administered 8-16 mg (initial dosage), if necessary, can be increased to 8 mg.
Instructions for use of lornoxicam also allows for the following maximum dose:
- Ingestion - 16 mg per day;
- parenterally - 8 mg per day.
Overdose
Use of the drug in high doses is fraught with an increase in side reactions of the nervous system and the gastrointestinal tract, in addition, may heart or acute renal failure and rise arterial pressure .
As treatment is carried out gastric lavage, monitoring and maintenance of vital functions. Assign Activated carbon .
Cooperation
The use of lornoxicam with others NSAIDs increases the likelihood of side effects.
In combination with indirect anticoagulants bleeding can occur.
The tool also increases the hypoglycemic activity of derivatives sulfonylureas It reduces nephrotoxicity antihypertensive drugs and raises it from diuretics , Weakening their effect.
Also, it increases the concentration of drug in blood plasma of lithium and lornoxicam in combination with Cimetidine .
Terms of sale
The drug is sold in pharmacies by prescription.
Storage conditions
Keep the medication should be out of the reach of children and well-protected from light. The temperature should be no greater than 25 ° C.
Shelf life
Shelf life of lornoxicam in tablet form is 5 years. Ready solution for injection should be stored no more than a day.
Analogs of lornoxicam
Teksamen
Artrozan
Amelotex
Movalis
Meloxicam
Ksefokam
Revmoksikam
Lornoxicam analogues which are manufactured under the trade name Ksefokam and Rapid Ksefokam - Larfiks and Lorak .
Reviews of lornoxicam
Reviews of lornoxicam by professionals and patients are usually positive . They testify to the effectiveness of this drug.
Price lornoxicam where to buy
Price lornoxicam in different pharmacies may be different. Tablets of 10 pieces in the package you can buy, on average, for 150 rubles.
And those who are appointed injections should buy special powder for injection. It is more expensive, the price of lornoxicam in this case will be about 700 rubles.
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