Description overdue on 08/08/2014
- Latin name: Priorix
- ATC code: J07BD52
- Active substance: Strain Schwarz + strain RIT 43/85 + strain Wistar RA 27/3 + neomycin sulfate
- Manufacturer: GlaxoSmithKline Biologicals, s.a. (Belgium)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Priorix, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The combination attenuated vaccine virus strains:
- e P idemicheskogo mumps (RIT 4385 derived Jeryl Lynn) not less than 4, 3 lgTTsD50;
- Measles (Schwarz) of at least 3, 5 lgTTsD50;
- Rubella (Wistar RA 27/3) at least 3, 5 lgTTsD50.
Viruses Measles and Mumps separately cultured in chick embryo cell culture.
Virus Rubella cultured in diploid human cells.
Auxiliary ingredients:
- neomycin sulfate;
- lactose;
- mannitol;
- sorbitol;
- amino acids.
In the form of solvent included is water for injection.
Product form
The lyophilisate is used for further preparing a solution for subcutaneous (s / c) and intramuscular (i / m) administration in vials with a solvent-filled syringes with needles or more ampoules. The powder in the form of a homogeneous porous mass of white or slightly pink.
Pharmacological action
Immunomodulatory.
Pharmacodynamics and pharmacokinetics
Vaccine Priorix develops immunity against rubella, measles and mumps . The clinical tests showed high efficacy of the drug. Antibodies to Rubella were detected at 99, 3% of patients vaccinated Priorix, virus Measles 98%, to the virus mumps 96, 1%. After 12 months after Vaccination all seropositive patients to save protective titer antibodies to viruses Rubella and Measles , Virus Mumps protective titer It remained at 88, 4% of people.
Priorix vaccine meets all the requirements of the WHO for the production of biological medicines and vaccines requirements. In any case, domestic or Priorix vaccine is up to you, so go to that choice responsibly and do not neglect the advice of your doctor.
Indications
Preventing viruses Rubella . Measles and mumps , Appointed by the age of 12 months.
Contraindications
- individual hypersensitivity to any ingredient of the drug, including a protein of chicken eggs;
- primary immunodeficiency;
- secondary immunodeficiency;
- allergic reactions in the preceding administration of the vaccine;
- pregnancy;
- acute respiratory disease and chronic periods of exacerbation, accompanied fever .
Side effects
Often:
- rash;
- hyperemia , Swelling and pain at the injection site;
- fever.
Rarely:
- increase salivary parotid glands ;
- convulsions against increase in temperature.
Rarely:
- Complications specific to upper respiratory tract ( cough, rhinitis, bronchitis etc.);
- vomiting;
- diarrhea;
- anorexia;
- irritability;
- drowsiness ;
- insomnia ;
- lymphadenopathy;
- acute otitis media .
Priorix, instructions for use (method and dosage)
Vaccine intended for subcutaneous (dose of 0, 5 ml) or intramuscular administration.
Intravenous administration of the drug is not allowed.
According to the preventive vaccination schedule shows Russia Priorix vaccination pediatric patients 12 months with a further booster at 6 years. Also Priorix can be administered to girls as young as 13 years old are not vaccinated or previously received only one vaccination vaccines Rubella . measles and mumps (monovalent or combined).
Preparation of injection solution
Immediately prior to administration of the vaccine vial or ampoule contents making filled syringe is supplied with solvent at the rate of 0, 5 ml per dose.
The bottle was shaken thoroughly until a homogeneous solution (transparent liquid light red or light orange). The dissolution time of the powder should not exceed 60 seconds.
If the prepared solution acquires a different color or has a foreign matter, the vaccine is not applicable.
For administration Priorix using another sterile needle. In applying the drug in multi-dose packaging for each new fence is necessary to use a new syringe with a sterile needle.
To avoid possible complications of the prepared solution should be used within 8 hours with storage conditions at temperatures ranging from 2 ° C to 8 ° C (in a refrigerator). The drug is extracted from the bottle in compliance with all the rules aseptic .
Overdose
There is no information about overdose Priorix.
Cooperation
Priorix allowed introduction of the drug at the same time (the same day) with DT and DTP vaccines, vaccine Haemophilus influenzae type b , Live and inactivated vaccine Polio , Vaccine Hepatitis B . Other vaccines are in new areas of the body separate syringes. Other vaccinations are not earlier than 30 days after the injection of Priorix.
Priorix may be used for repeat vaccinations persons previously vaccinated other combination vaccines.
Pediatric patients receiving the drug in human blood, vaccination is carried out not earlier than 90 days due to the possible failure of the procedure as a result of passive embedded antibodies to the vaccine viruses mumps, measles and rubella . If blood preparations were administered after less than two weeks after the procedure Vaccination , The latter should be repeated.
In case of necessity of tuberculin test , It should be carried out with Vaccination or after 6 weeks, due to the possibility of false results.
Terms of sale
Vaccines are dispensed from pharmacies by prescription.
Storage conditions
Priorix vaccine together with the solvent must be stored at 2 ° C to 8 ° C.
With separate packaging of the vaccine and the solvent allowed to store the last at a temperature of from 2 ° C to 25 ° C
Shelf life
Vaccine - 2 years.
Solvent - 5 years.
Cautions
Contact dermatitis history caused by neomycin , and allergic reaction for eggs, excluding anaphylactic It is not a contraindication to Vaccination .
The vaccine may be administered to patients with asymptomatic HIV and AIDS .
In acute intestinal and other diseases, as well as SARS light weight, allowed the introduction of the drug immediately after the normalization of body temperature.
During pregnancy and lactation
Application Priorix during pregnancy is prohibited.
Reviews of Priorix
Reviews of Priorix share of approximately 60% (positive) to 40% (negative). It should be remembered that any immunizations are certain risk of possible complications, ranging from stress baby from the most to the development of injection anaphylactic reactions (rarely). When selecting a vaccine is to consult with experts and to comply with all measures for the storage and transportation of the drug.
Priorix vaccine is often compared to the domestic production of vaccines, but the views are so different that the output of the absolute leader and failed. Priorix undoubted advantage is its single administration compared with domestic counterparts, administered twice. The downside for people with allergies is considered to be the production of Priorix based on chicken eggs, while the Russian vaccine manufactured using the quail.
Side effects that occur after vaccination, as the Belgian and our vaccine is most often the same and are as fever, mild cough, rash , Small runny nose. Serious complications are extremely rare and often occur in non-compliance with the temperature regime of storage and transportation.
Check the storage conditions of the drug, ask questions in the professional forums, for example - on Online doctor Komarovsky .
Price Priorix where to buy
At the moment, the presence of Russian pharmacies vaccines Priorix is a particular problem, and perhaps it will have to buy the book or in the centers vaccination.
Price Priorix in Russia on average from 300 to 350 rubles.
Buy Priorix in Moscow easiest in specialized medical institutions, where the price includes a preliminary examination of the child and the vaccination itself.
Buy vaccine in Yekaterinburg can be in the same price range.
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