Ibuprofen

Description overdue on 28.10.2011

Related Articles:

• Olfen
• Bifosin
• Valocordin
• Diana, 35 reviews about the drug

Tweet

The drug from the group of NSAIDs. It has a pronounced analgesic, anti-inflammatory and analgesic effect. When ibuprofen notes antiplatelet effect . For external use Ibuprofen reduces morning stiffness in the joints, helps to restore full range of motion.

Indications:

Diseases ASO inflammatory and degenerative: psoriatic, juvenile, rheumatoid, ankylosing spondylitis , Chronic arthritis , Osteoarthritis, neuralgic amyotrophy, osteochondrosis Arthritis in SLE, gouty arthritis. Ibuprofen relieves pain: ossalgia, myalgia, radiculitis , Arthralgia, migraine , Arthritis, toothache, headache, tendinitis . neuralgia , Cancer, bursitis, tenosynovitis, post-traumatic pain. Inflammatory processes in the pelvis, tuberculosis, adnexitis, infectious fever, colds.

Contraindications:

Erosive and ulcerative lesions of the gastrointestinal tract, "Aspirin" asthma, Crohn's disease , Bleeding diathesis, bleeding tendency, hemophilia, pregnancy. Precautions Ibuprofen is prescribed for cirrhosis of the liver (portal hypertension +), gastritis, hyperbilirubinemia, colitis , Enteritis, nephrotic syndrome , Hepatic, renal failure, heart failure, anemia, leukopenia of unknown etiology, hypertension. Ibuprofen is not applied in paediatrics.

Side effect:

GI: NSAID-gastropathy, dyspepsia, dry mouth, gum irritation, aphthous stomatitis, hepatitis, constipation , Pancreatitis. Respiratory system: dyspnea attacks, bronchospasm . Special Senses: tinnitus, hearing loss, optic neuritis toxic origin (reversible character), diplopia, eye irritation and dryness, scotoma. Nervous system: anxiety, insomnia, headaches, agitation, and depression. Nephrotic syndrome, allergic nephritis, renal failure, cystitis , Polyuria. Bodies of hematopoiesis: aplastic anemia, thrombocytopenic purpura, leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia. Sweating. Allergies.

Mode of application:

Ibuprofen taken orally, preferably after a meal. Psoriatic arthritis, osteoarthritis, ankylosing spondylitis 4 times per day, 400-600 mg. Rheumatoid Arthritis: three times a day at 800 mg. Stretching, soft tissue injury: 1, 6-2, 4 grams per day (multiple doses). Algomenorrhea 4 times daily 400 mg. Feverish syndrome after immunization: 50 mg. After 6 hours again. In no more than 100 mg per day.

Overdose:

Confusion, dyspepsia, vomiting, drowsiness, tinnitus, drop in blood pressure, metabolic acidosis , Coma, bradycardia, Atrial fibrillation Tachycardia, respiratory arrest, kidney failure. With an overdose of ibuprofen is necessary to wash out the stomach, put in an hour adsorbents.

Special instructions:

During treatment with ibuprofen requires careful monitoring of the blood, liver and kidney systems. At the first sign gastropathy spend EGD, fecal blood, determine the hematocrit . For the prevention of gastropathy it is recommended to combine misoprostol and ibuprofen. The drug reduces the rate of reaction is not combined with ethanol.

Drug Interactions:

When combined with inducers of microsomal oxidation (barbiturates, ethanol, phenytoin, rifampicin Tricyclic antidepressants, phenylbutazone) amplified hepatotoxic effects on the liver. MAO inhibitors, in contrast, reduces the severity of the toxic effect of ibuprofen on the liver. The drug reduces the diuretic effect hydrochlorothiazide   and of furosemide . It enhances the effectiveness of indirect anticoagulants, fibrinolytic agents, antiplatelet agents. Kolestiramin and antacids reduce the absorption of ibuprofen. Under the influence of drugs increases the concentration of methotrexate Digoxin , Lithium preparations. Caffeine   It stimulates the analgesic effect of ibuprofen.