Danoval

Description overdue on 24.03.2012

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Antigonadotropnym drug . The active component is danazol   - Adrogué synthetic origin, prepared from   ethisterone . The mechanism of action is aimed at suppressing production gonadotropins   FSH and LH by the pituitary gland in persons, male and female. Women Danoval calls atrophy of the endometrium Inhibits Ovulation , Inhibits the activity of the ovaries. The high concentration of drug causes mild androgenic effects, anabolic effects . Drug action reversible, danazol has no gestagenic and estrogenic effect. The drug leads to regressive changes in endometrial lesions, reduces the severity of pain associated with endometriosis. Danoval causes partial (sometimes full) elimination of nodes in patients with seals fibrocystic mastopathy And relieves pain. The drug inhibits the proliferation of lymphocytes, has immunosuppressive effect . In women with endometriosis reduces autoantibody production, and reduces immunoglobulins . Clinical efficacy Danovala patients with hereditary angioedema due to higher content of C1 esterase inhibitor (component causes an increase in the level of compliment C4). Danoval available in capsule form.

Indications:

Danoval prescribed for fibrocystic breast and other benign breast disease At endometriosis   (from infertility ) primary menorrhagia Hereditarily angionervoticheskom edema , Primary premature puberty, when premenstrual syndrome .

Contraindications:

Danoval not prescribed for porphyria   (increased liver enzyme levels), pregnancy, thromboembolism , Renal diseases, liver, with Vaginal bleeding , Androgenozavisimyh tumors. In violation of plasma mechanisms of hemostasis, migraine Epilepsy, diabetes   administered with caution.

Side effects and overdose:

Danoval can cause fluid retention, hypersecretion of the sebaceous glands "Vulgar" acne, deepening of voice, decrease in breast size, profuse perspiration, blood flow to the skin of the face, emotional lability, dizziness, nausea, disorders of spermatogenesis , Weight gain, virility syndrome, vaginitis, cholestatic jaundice, leukocytosis, sleep disturbances, paresthesia, lumbalgia, increased intracranial pressure, headaches, spasm of skeletal muscles, disorders of visual perception, polycythemia, dysmenorrhea , Alopecia, hepatitis. If overdose is registered vomiting, convulsions, tremors, nausea, headaches. Requires posindromnoy therapy, gastric lavage.

Mode of application:

Danoval taken orally. Therapy begins with the first day of menstruation. Adults appoint at 200-800 mg daily dose is divided into 2-4 reception. Benign tumors of the mammary glands: 100-300mg daily, a course of 3-6 months. Endometriosis: initially 400 mg, then 800 mg of 6 months duration of reception. Prevention of angioedema: 200 mg initially, then reduce the amount of drug in the absence of clear signs of exacerbation within 1-3 months. When precocious puberty children appoint 100-400 mg.

Special instructions:

The drug is recommended to be under the control of liver enzymes. Never use Danoval drug as a contraceptive drug. In persons with diabetes receiving drug antigonadotropnym require dose adjustment of insulin.

Drug Interactions:

Danoval may cause bleeding while taking derivatives and indandiona coumarin anticoagulants . The drug increases the concentration of glucagon, tacrolimus, cyclosporine (high risk of nephrotoxicity). Danoval increases carbamazepine   in the blood, it inhibits its metabolism. The medicament weakens the effect of oral hypoglycemic agents and insulin.