Description overdue on 09/29/2014
- Latin name: Omez D
- ATC code: A02BX
- Active substance: Domperidone + Omeprazole (Domperidone + Omepazole)
- Manufacturer: Torrent Pharmaceuticals (India)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Omez D
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Part Omez D It includes two active ingredients: domperidone and omeprazole (in the form of pellets which are coated, soluble in the gut). Auxiliary ingredients are magnesium stearate, MCC, carboxymethylstarch sodium, colloidal silicon dioxide, sodium lauryl sulfate, talc.
Product form
It is produced in the form of hard gelatin capsules. The capsules have a white body and cover light purple. In the capsule is the inscription «Omez D» logo «DR.REDDY'S». Inside the capsule - a whitish powder.
Capsules fit into strips 10 pcs., Which fit into cardboard boxes.
Pharmacological action
The combined facility Omez D contains omeprazole and domperidone, which is a dopamine receptor blocker central action.
Under the influence of domperidone increases peristalsis of the duodenum and the antrum. During deceleration of gastric emptying effect of this substance allows you to activate the process. Domperidone stimulates the tone of the lower esophageal sphincter, does not allow the display of vomiting and nausea. The substance stimulates the production of prolactin pituitary gland.
Omeprazole blocks the final stage of hydrochloric acid secretion. As a consequence, reduced basal and stimulated secretion.
The combination of omeprazole decreases the secretion of hydrochloric acid and domperidone increases esophageal sphincter tone and gastric emptying activates. As a consequence, it reduces the aggressiveness of gastric juice into the esophagus reflux of the stomach contents.
Pharmacodynamics and pharmacokinetics
Domperidone the BBB gets bad, so when using domperidone extrapyramidal side effects are rare. The substance after oral administration is absorbed rapidly. Bioavailability - about 15%. The highest concentration in plasma - 1 hour. Is distributed to all tissues, binds to plasma proteins is approximately 90%. Metabolism occurs in the liver and gut wall. It derived from an organism through intestine, and kidneys.
Omeprazole after ingestion takes effect within 1 hour, 2 hours maximum effect. Exposure is continued for 24 hours. Experienced rapid adsorption of substances from the digestive tract, the largest concentration in the plasma - about 1 hour. Bioavailability - 30-40%. The plasma protein bond - by about 90%. Omeprazole is almost completely metabolized in the liver. The major part eliminated via the kidneys, about 30% - in the bile.
Indications Omez D
Indications for use of the drug - therapy dyspepsia and gastroesophageal reflux in the case monotherapy proton pump inhibitors or other drugs is ineffective.
Contraindications
Contraindications to treatment are those Omez D status and disease:
- Hypersensitivity;
- stomach or intestinal bleeding;
- perforation of the stomach or intestines;
- obstruction of the digestive tract mechanical nature;
- prolactinoma;
- lactation ;
- children's age.
Carefully agent used in hepatic and renal failure, in the period pregnancy .
Side effects omez
At reception domperidone may occur following side effects:
- transient intestinal cramps ;
- hives . skin rash ;
- extrapyramidal disorder ;
- hyperprolactinemia .
When receiving omeprazole sometimes observed these side effects:
- Functions of the digestive tract : Dyspepsia, taste disturbances, a feeling of dryness in the mouth, stomatitis, increased plasma liver enzymes.
- Nervous system : drowsiness , Dizziness, insomnia . headache . depression Manifestation of hallucinations.
- Locomotor apparatus : Myalgia, muscle weakness, arthralgia.
- Hematosis : Thrombocytopenia, leukopenia.
- Skin : Skin rash, itch .
- Allergic symptoms Edema, hives , Bronchospasm, fever.
- It may also be violated vision, marked sweating, during long-term therapy in rare cases can develop gastric glandular cysts.
Instructions for use (method and dosage)
If the patient is assigned Omez D, instructions for use provided that the capsules need to take 1 piece. twice a day. It is advisable to take the drug for about 20 minutes before eating. Instructions for use D Omez provides that when taking capsules should be taken with a little liquid.
Overdose
In case of overdose of domperidone patient may develop disorientation, seizures, drowsiness, extrapyramidal reactions. In this case it is necessary to take the activated carbon. If the patient developed extrapyramidal reactions, you should take anticholinergics, antihistamines, antiparkinsonian drugs.
If an overdose of omeprazole, the patient may be in breach of consciousness, visual disturbances, nausea, headache . arrhythmia . In this case, apply symptomatic therapy.
Cooperation
Anticholinergic medications neutralize effect of domperidone.
In simultaneous treatment with sodium bicarbonate, cimetidine and other antacids and protivosekretornye means reducing the level of bioavailability of domperidone.
Antibiotic (macrolide), antifungal drugs belonging to the azole series, nefazodone, HIV protease inhibitors increase the level of concentration in the blood plasma of domperidone.
Omeprazole may reduce the absorption of esters, salts of iron, itraconazole and ketoconazole, ampicillin. Also, the substance may reduce the excretion of anticoagulants of indirect effects, phenytoin, diazepam. Sometimes it is necessary to reduce the dose of these drugs.
Omeprazole increases effect of other drugs on the hematopoietic system.
Terms of sale
Omez D realized prescription specialist.
Storage conditions
Save tool needed in a dark and dry place at a temperature not exceeding 25 ° C. The drug should be protected from children.
Shelf life
Shelf life of capsules - 2 years.
Cautions
Before therapy is necessary to conduct a survey and eliminate all malignant diseases of the digestive system, as a means for the treatment of the symptoms may be masked.
Care must be taken to drive vehicles and operate with dangerous devices during the treatment period.
Analogs Omez D
Vikair
Gastrofarm
Gaviscon
Vikalin
Pharmacies can buy both imported and domestic counterparts Omez D. This medication Deksilant . WES . Omeprazole . Lansoprol . Demeprazol . Zerotsid . Krismel . Omekaps . Gastrozol . Omezol . Ultop and etc.
Babies
Babies drug treatment is not assigned, because accurate information about his safety there.
During pregnancy and lactation
Pregnant women Omez D appointed only if the benefits of such therapy outweighs the risk to the fetus. Breastfeeding in the treatment of the drug should be stopped.
Reviews Omez D
Reviews of physicians and patients about this medicinal product in the majority of the positive. It is noted that in addition to the D Omez improvement of the patient with ulcers and other gastrointestinal diseases effectively relieves patients from constipation . Side effects are very rare.
Price Omez D, where to buy
Price Omez D on average 200 - 250 rubles per pack of capsules 30 pcs.
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