Nebilet

Description overdue on 18.06.2012

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Cardioselective beta 1-blocker . The active ingredient of the drug - nebivolol. The drug has antianginal, hypotensive and antiarrhythmic effects. Nebilet able to reduce high blood pressure at rest, under stress during physical activity. The drug selectively blocks the competitive extrasynaptic, synaptic beta-adrenergic receptors, protecting them from catecholamines. The hypotensive effects due to the influence of the drug on the renin-angiotensin system. In the first days of therapy recorded an increase round, but long-term treatment leads to a decrease in this indicator. Stable effect of the drug observed after 1-2 months of use. Taking medication reduces the frequency of angina attacks, reduces the need for oxygen cardiomyocytes. Antiarrhythmic effects   due to the suppression of cardiac automatism slowdown atrioventricular conduction . Nebilet is available in tablet form.

Indications:

Nebilet is prescribed for angina, hypertensive crisis , Arterial hypertension, arrhythmia, myocardial infarction, unstable angina form.

Contraindications:

Nebilet does not apply to the form deokompensirovannoy CHF, nebivolol intolerance, atrioventricular block grade 2-3, cardiogenic shock, pheochromocytoma , SA-blockade, hypotension, depression, Prinzmetal angina , Myasthenia gravis, obliterating peripheral vascular disease. During pregnancy, thyroid disease, diabetes, renal disease, breast feeding, allergies, elderly nebivolol prescribed with caution, after prior consultation of experts.

Side effect:

Cardiac arrhythmias, edema, orthostatic hypotension , Bradycardia, convulsions, headache, dizziness, dry mouth, vomiting, false angina, heart block, Raynaud's syndrome , Nausea, insomnia, drowsiness, depression, decreased concentration, hallucinations, photodermatosis, allergy, "nightmarish" dream, cyanosis, bronchospasm, rash, rhinitis.

Overdose:

Manifested by loss of consciousness, bronchospasm , Atrioventricular block, cardiogenic shock, sinus bradycardia , A fall in blood pressure, cyanosis, vomiting, nausea, coma. It requires gastric lavage, emergency administration of beta-agonists, atropine sulfate. In the absence of adequate response administered norepinephrine, dobutamine, dopamine, glucagon. Subsequently, it is recommended to install intracardiac transvenous pacemaker. At ventricular arrhythmia   injected lidocaine, with bronchospasm - intravenous infusion of a stimulant beta2-adrenergic receptors, in convulsions - intravenous diazepam.

Mode of application:

Take Nebilet 5mg daily by mouth. In some cases, the dose was increased to 10 mg. Elderly with renal pathology system to reduce dosage of 2 and 5 mg. In CHD nebivolol lifted gradually within two weeks.

Special instructions:

The efficacy of Nebilet in smokers is significantly lower than in those without nicotine addiction. At angina   the dose selected based on achieving indicator resting heart rate of 55-60. Control of the patients who take nebivolol includes monitoring of blood pressure, heart rate, an indicator of sugar. The elderly need to control the work of the renal system. Nebilet able to strengthen the symptoms of impaired peripheral blood circulation . When hyperthyroidism nebivolol eliminates tachycardia at diabetes   masks hypoglycemia. The drug is able to enhance the response to pollen allergic patients. Abrupt withdrawal of the drug is illegal. The treatment may reduce the secretion of tear fluid, which is necessary to warn patients who wear contact lenses. When pregnancy Nebilet shown on strict conditions. The drug is cancel 48-72 hours before delivery. Otherwise, after the birth of a child is monitored for three days. Nebilet affects driving.

Drug Interactions:

The risk of developing anaphylaxis   and systemic allergic reactions increases during skin tests with extracts of allergens, carrying Immunotherapy   allergens. Against the background of the use of iodine-containing X-ray contrast agents may develop anaphylactic reactions. Preparations for the common inhalation anesthesia, phenytoin   by intravenous infusion increases the likelihood of a drop in blood pressure, the severity of the impact cardiodepressive. Nebilet affect the effectiveness of oral hypoglycemic agents Effectiveness of insulin hypoglycemia masked. Nebivolol reduces the clearance of xanthine, lidocaine. Estrogens, NSAIDs, steroids weaken hypotensive effect of the drug. Antiarrhythmics amiodarone, diltiazem , Verapamil, guanfacine, reserpine, methyldopa, cardiac glycosides worsen bradycardia, heart failure, atrioventricular block. Nifedipine can significantly reduce blood pressure. Clonidine, diuretics, hydralazine, sympatholytic, other antihypertensive agents can significantly reduce blood pressure. The drug prolongs the action of coumarin, non-depolarizing neuromuscular blocking agents. Sedatives, and tricyclic tetracyclic antidepressants , Antipsychotics, hypnotics, dampening effect on the central nervous system. It is unacceptable the simultaneous appointment of MAO inhibitors. The risk of peripheral blood circulation increases in the appointment of non-hydrogenated ergot alkaloids.