Description overdue on 05/16/2014
- Latin name: Fluimucil - antibiotic IT
- ATC code: J01BA02
- Active substance: Thiamphenicol glycinate atsetiltsisteinat (Thiamphenicol glycinas acetylcysteinas)
- Manufacturer: Zambon, Italy
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- With antibiotics
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- With antibiotics
- With antibiotics
Composition
One vial contains: atsetiltsisteinat thiamphenicol glycinate - 0 81 g, including thiamphenicol 500 mg; extra ingredient - disodium edetate; and water as solvent.
Product form
The powder obtained by lyophilization of a solution which is ready; in bottles together with the solvent, 3 pcs. per bundle.
Pharmacological action
The substance is a compound antibiotic and mucolytic drug.
Thiamphenicol has a broad spectrum of activity against bacteria that cause respiratory tract infections - how Gram-positive (streptococci, Clostridium, Staphylococcus), and Gram (neisserial, Haemophilus influenzae, Salmonella, Yersinia, E. coli).
Acetylcysteine actively liquefies phlegm and purulent discharge, favors the discharge of sputum, reducing viscosity.
Acetylcysteine better penetration thiamphenicol in lung tissue and prevents the adhesion of microorganisms on the mucosa of the respiratory system.
Pharmacodynamics and pharmacokinetics
Thiamphenicol It accumulates in the airways, and the maximum concentration occurs within 1 hour after injection into a muscle. The half - 3 hours, excreted in the urine.
Acetylcysteine It accumulates in the intercellular space, bronchial secretions, lung tissue, liver and kidney. The half - 2 hours; excreted by the kidneys, and a small part - through the intestines.
The drug crosses the placenta.
Indications
- loss of upper respiratory tract and upper respiratory tract ( sinusitis . otitis . laryngotracheitis );
- diseases of lower respiratory ( bronchitis , Lung abscess, pneumonia , Bronchiectasis, cystic fibrosis, emphysema . whooping cough . bronchiolitis );
- treatment and prevention of infectious complications and obstructive nature of the tracheostomy, thoracic surgical interventions (atelectasis, pneumonia);
- Preparations for the aspiration of bronchial secretions and bronchoscopy;
- in order to improve drainage in the related lung infections (including at tuberculosis , The presence of cavernous foci).
Contraindications
- disease and changes in blood counts ( leukopenia . anemia . thrombocytopenia );
- idiosyncrasy substances in the preparation.
The function of the kidneys in children during the first 2 years of life has features associated with age, so they, as well as in patients with severe liver and kidney drug should be used with caution.
Side effects
Allergic reactions.
When administered into the muscle may be burning at the injection site; rarely leukopenia, thrombocytopenia, anemia, neutropenia, reticulocytopenia.
Applying Fluimucil antibiotic for inhalation can cause irritation of the respiratory tract, cough reflex character, nausea, rhinitis. Sometimes bronchospasm, it should be used bronchodilators.
Instructions for use Fluimucil - antibiotic IT (method and dosage)
Intramuscularly in the dose used:
- adults: 1 500 mg per day in 3 divided doses;
- children under three years of 125 mg twice a day;
- Children from 3 to 7 years - 250 mg twice a day;
- Children from 7 - 12 years, 750 mg per day, divided into 3 injections.
Infants up to 2 weeks and used in preterm dose rate of 25 mg / kg body weight per day.
How to breed for inhalation?
Adults powder substance 500 mg was dissolved in 4 ml of water for injection and divided into 2 doses per day (2 mL). Inhalation children prepared in the same amount of water for injection as adults (4 ml) was dissolved 250 mg of the powder and also applied twice a day.
Local rinsing the sinuses, including after surgical interventions, for administration through endotracheal tracheostomy, endotracheal tube or bronchoscope powder was dissolved using water for injection in an amount of 4 ml - 500 mg and 250 mg to adults children.
At otitis and diseases of the nasopharynx in the nostril or ear canal instill 2-4 drops.
In the case of the relevant indications, the dose can be doubled.
In newborns, premature infants and older patients do not increase the dose.
Instructions to determine the antibiotic course of treatment no more than 10 days.
Overdose
Perhaps increased side effects of the drug, superinfection, violations of the bacterial flora. As treatment is used symptomatically.
Cooperation
In the case of the use of funds from the cough phlegm stagnation may occur.
The aerosol inhalation Fluimucil antibiotic mixed with other substances is not recommended.
Terms of sale
Prescription.
Storage conditions
Away from children at a temperature of 15 to 25 ° C.
Shelf life
3 years.
Cautions
During treatment requires constant monitoring of the blood formula. By reducing the number of granulocytes and leukocytes drug you want to cancel.
Avoid contact with the solution of rubber and metal surfaces.
Analogs
It has no analogues.
Babies
Apply with caution to children under two years, due to the age characteristics of kidney function.
During pregnancy and lactation
Assign only when the benefits outweigh the risks for the woman to the fetus. During breast-feeding, if necessary, treatment of the feeding must be stopped.
Reviews of Fluimucil - antibiotic IT
In many medical forums reviews of Fluimucil available - an antibiotic usually from young mothers who used inhaled antibiotic for the children. Celebrating quick effect - literally 3-4 days the child's condition improves. Those who has ever tried the drug, with a recurrence preference to him. Very good use for the drug nebulizer - And conveniently, and efficiently.
Price Fluimucil - antibiotic IT where to buy
In Russia, the price Fluimucil antibiotic IT It ranges from 413 to 605 rubles.
Average price Fluimucil inhalation in Moscow, about 538 rubles. In Ukraine, the drug can be bought for 174 USD.
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