Description overdue on 01.12.2011
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The preparation Reduxine has anoreksigennoe and enterosorbiruyuschee impact . After his admission absorption from the gastrointestinal tract occurs at 77%. In tissues distributed quickly enough. Four days after initiation of therapy in the patient's blood is observed CSS active metabolite . With the process of active metabolites hydroxylation and conjugation Then obrazovyvajutsja inactive metabolites Which go mainly through the kidneys. The medicament is a combined preparation, the components active in the body. Substance sibutramine - A prodrug, which affects in vivo . Sibutramine has the ability to block the reuptake Serotonin and noradrenaline . By its action in synapses an increasing number of neurotransmitters , So there is a manifestation of the high activity of central serotonin and adrenergic receptors. Thus, a person feels satiation faster, thus its need for food becomes lower. This increases termoproduktsiya. There is also an active influence on the brown adipose tissue by activating b3-adrenoceptor . During active weight reduction in serum concentration increases HDL level decreases triglycerides . cholesterol . Uric acid .
The preparation also included Reduxine microcrystalline cellulose . This enterosorbent exhibits sorption properties and detoxification effect. Under its influence the body are derived from microorganisms, toxins and excess metabolites of certain metabolic products that trigger the endogenous toxemia.
Indications and methods of use of the drug:
To reduce the weight of the drug is prescribed for patients with alimentary obesity Whose body mass index greater than 30 kg / m2. It is used in alimentary obesity with a BMI of 27 kg / m2 or more, which combines non-insulin diabetes or dyslipoproteinaemia .
Take this drug should be once a day, in the morning, plenty of drinking water and without chewing. It does not matter meal period.
The dose of the drug PCP should set individually.
The initial dose should be 10 mg if the drug is poorly perceived, the dose can be reduced by half. If the effect is not observed, that is, it resets the patient for at least 2 kg for four weeks, then if tolerated dose of agent can be increased to 15 mg per day. No need to continue therapy after three months of taking the drug to those patients who have failed to lose weight during this time by 5% from the initial level as well as in patients who have shown a negative reaction to the drug.
We should not practice further treatment, if after a weight loss during the treatment according to the patient drugs gaining more than 3 kg. The period of administration of the drug can not continue Reduxine bole two years, due to the fact that the information on the safety of the drug over a long period of time is absent.
Treatment of this tool must necessarily be combined with diet and exercise.
Contraindications and possible side effects:
The drug should not be used under the following conditions: high sensitivity to a substance sibutramine or other components Reduxine organic prerequisites to obesity, severe eating disorders, mental illness, de la Tourette syndrome . You can not use in patients with concurrent MAO inhibitor therapy or in their application for two weeks before you start taking this drug, taking serotonin reuptake inhibitors, taking any medications that affect the central nervous system, hypnotics, drugs that contain tryptophan And other drugs for weight reduction of the central action. This drug is also contraindicated in diseases of the cardiovascular system, uncontrolled hypertension (if there is more than blood pressure 145/90 mm Hg. st), thyrotoxicosis , Severe violations of the liver, kidneys, pheochromocytoma . benign prostatic hyperplasia . angle-closure glaucoma . pregnancy and breastfeeding . The drug can not be used for children and adolescents who are under 18 years old and people over 65, those who have seen drug, alcohol, drug dependency.
Caution when administered Reduxine Arrhythmias a history cholelithiasis . chronic circulatory failure . Coronary Artery Disease . hypertension , Neurological disorders, disturbances in the functioning of liver, kidney, mild to moderate, with a history of motor and verbal tics. Women who are in childbearing age should be sure to use the funds for protection from conception during treatment with this drug.
Adverse effects during the treatment may occur in the first four weeks of use of the drug. They are generally not severe. Over time, they become less pronounced.
In work CNS may insomnia , Dry mouth (often), dizziness, headaches, paresthesia , Anxiety, change in taste (sometimes). In the cardiovascular system is manifested tachycardia . increased blood pressure . vasodilatation (sometimes).
In work GI may be loss of appetite, constipation (common); sometimes it may appear nausea, exacerbation Hemorrhoids . In case of complaints of the patient on the treatment of constipation should stop and take a laxative. As a side effect may also occur high perspiration. Described isolated cases of manifestations dysmenorrhea , Edema, influenza-like syndrome, back pain and abdominal pain, pruritus, increased appetite, thirst , Depression, somnolence, rhinitis , Anxiety, irritability, acute interstitial nephritis, bleeding, Henoch-Schönlein , Seizures, thrombocytopenia .
Specific recommendations:
The consumption of alcohol by means of parallel amplification Reduxine negative influence of alcohol is not manifested. However, the reception of alcoholic beverages is not aligned with the recommended diet.
This tool should be used only in cases where diet, exercise does not have the desired effect, then there are lots of 3 months has decreased by less than 5 kg. Use of the drug Reduxine should be done only under the close supervision of a specialist. It is necessary in this case to adopt an integrated approach to the problem, that is to change the principles of nutrition, increase physical activity. It is very important in the treatment process to review and change their own habits to follow a way of life after the end of treatment provoked a return of excess weight.
During the treatment you need to keep under control the blood pressure and heart rate. Be particularly careful to monitor the state of the patient should be treated with hypertension . If you double-control when measuring blood pressure exceeds 145/90 mmHg, the Message reception is suspended. When you miss a dose two tablets the next time should not be accepted, and to carry out the treatment under the scheme. Treatment with Reduxine should not last more than two years. The drug can affect the ability to work with dangerous machinery and driving vehicles.
