Dazolik

Description overdue on 07/18/2014

• Latin name: Dazolic
• ATC code: P01AB03
• Active substance: Ornidazole (Ornidazole)
• Manufacturer: Sun Pharmaceutical Industries Ltd. (India)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Dazolik, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Each tablet contains as components:

• ornidazol (basic active agent tablets Dazolik) - 0, 5 mg;
• starch;
• microcrystalline cellulose (MCC);
• sodium lauryl sulfate ;
• polyvinylpyrrolidone K90;
• purified talc;
• magnesium stearate;
• colloidal silica;
• sodium starch glycolate   type A;
• eudrazhit E-100 ;
• titanium dioxide;
• polyethylene glycol 6000;
• isopropyl alcohol;
• acetone;
• purified water.

Product form

Biconvex tablets White round shape or close to white color. Each piece is covered by a shell and has a characteristic risk on one party. The tablets are placed in an aluminum foil blister packs or PVC of 10 pieces each. Cardboard packaging can accommodate 1 or 5-well plates and profile.

Pharmacological action

Dazolik - it antibiotic   antiprotozoal nature, that is, basic pharmaceutical effect of the drug is aimed at the destruction of microorganisms that are the simplest. In particular, the active drug components disrupt the structure of the chains deoxyribonucleic acid , The main carrier of genetic information necessary for the normal functioning and reproduction of live cells. Antibiotic properties effective for a broad range of microorganisms which include:

• Giardia lamblia   ( intestinal lamblia );
• Trichomonas vaginalis   ( vaginal trichomonas );
• Entamoeba histolytica   ( dysentery amoeba );
• Clostridium perfringens   ( Clostridium perfringens );
• Bacteroides fragilis   ( Bacteroides fragilis );
• Fusobacterium nucleatum   ( fuzobakterii nucleoid   or Wand Plaut ).

It should be noted that the last three kinds of harmful microorganisms are anaerobic microflora That is, for the normal functioning of these cells do not need oxygen. As a rule, these families cause especially severe damage to deep structures of the human body, which sometimes lead to gangrene As absolute therapeutic indications.

Pharmacodynamics and pharmacokinetics

The main constituent elements of sufficiently rapid and complete (bioavailability of the drug is good 90 percent) absorbed from the gastrointestinal tract after oral administration. Maximum plasma concentration is achieved in 1-2 hours, depending on the individual indicators metabolism . At least 15 percent of the biological substances Dazolika communicates with its blood proteins. At 13 hours after administration of tablets constituent components can penetrate through blood-brain barrier .

Displayed mostly kidneys antibiotic drug - about 60-70 percent of all metabolic products. 20-25 percent is allocated through the feces. 5 percent of the dose is found in the non-modified form in the urine and feces.

Indications

• trichomoniasis ;
• amebiasis (including both outside the intestinal form of the disease, for example, amebic liver abscess And dysentery );
• giardiasis ;
• prevention of anaerobic infections   (used in the conservative treatment phase during operations on the colon and Gynecology).

Contraindications

• hypersensitivity Acquired or hereditary intolerance, idiosyncrasy with respect to the constituent components of the drug;
• periods pregnancy   (especially in the first trimester) and lactation (particularly breast-feeding );
• organic pathology   central nervous system.

Side effects

During the course of drug therapy Dazolikom may experience the following undesirable effects:

• On the side gastrointestinal tract : dyspeptic indigestion . nausea . vomiting . diarrhea .
• On the side central and peripheral systems : headache . dizziness , Impaired consciousness, rigidity of individual muscles . intentsionnogo tremor , Convulsions that resemble seizures epilepsy , The coordination of movements, especially fine motor skills, sensory or mixed peripheral neuropathy .

Dazolik, instructions for use (method and dosage)

Instructions for use Dazolika several different dosage and course of treatment, depending on the primary disease, which is carried out against the conservative antibiotic therapy.

At   trichomoniasis   , a dose of 500 mg twice daily (two tablets in 24 hours) for 5 days. In pediatric amount of pharmaceutical preparation calculated from body weight - 25 mg / kg of the tablets and make only once a day.

When treating amoebic infections   the amount of drug depends on the form of the disease. So when dysentery Induced Entamoeba histolytica   dosage is 1 to 5 g / day for a patient weighing about 35 kg or more. For patients with a body weight is used at 40 mg / kg daily in a single dose. The duration of medical treatment is 3 days.

If extraintestinal amebiasis , The drug is taken 2 times a day, morning and evening, and dosage will depend on age:

• children over 12 and adults, 500 mg;
• age group from 7 to 12 years - 375 mg;
• from 1 to 6 years - 250 mg;
• newborn to 1 year - 125 mg.

The course of the treatment should last from 5 to 10 days, determines the exact scope of the attending physician, depending on individual performance for the conservative therapy.

Giardiasis treated according to the following scheme - for adult age group and in pediatric patients weighing 35 kg or more - 1, 5 g twice daily. If the weight is below 35 kg diseased, then, as in the treatment of dysentery amoeba, the dosage is 40 mg / kg once per day. Duration of treatment - 1-2 days.

Preventive therapy anaerobic infections   drawn up in such a way - 0, 5-1 g once before surgery (the exact dosage of the operating surgeon sets of relevant indicators of the body), and then, after the operation, 500 mg 2 times a day for 3-5 days.

Overdose

Symptoms of increased concentration of active components in serum:

• epileptiform convulsions ;
• depression ;
• peripheral neuritis .

Specific antidote for the drug Dazolik pharmaceutical practice does not exist, because an overdose of the active components of the components used Symptomatic treatment . For example, to apply to stop seizures Diazepam , Soothing pharmaceutical formulation of the central type of action belonging to the benzodiazepine series tranquilizers .

Cooperation

Dazolik greatly enhances the therapeutic effects coumarin anticoagulants Which may manifest itself in the form of petechial hemorrhages . purpura   or purpura .

Ornidazole increases the duration of action miorelaksiruyuschego Vecuronium Bromide .

Terms of sale

The drug belongs to the B-list of international registry of pharmaceuticals as a potent, because in the pharmacy dispensed only by the assurance of physician prescription.

Storage conditions

Dazolik should be stored out of the reach of children and protected from direct light place at room temperature (18-22 degrees Celsius), but no more than 25 degrees Celsius.

Shelf life

35 years.

Cautions

At trichomoniasis   conservative therapy should be carried out simultaneously both sexual partners, as vaginal trichomonas   It is transmitted through sexual contact.

In no event should not disrupt the dosage regimen of the drug and reduce the rate of self-conservative therapy prescribed by the attending physician, as in the case of readjustment in any other antibiotic. Such actions can result in incomplete pharmaceutical drug action and the development of resistance to Dazoliku (and the whole group of antibiotics on the basis of Ornidazole ) From harmful microorganisms, which is fraught with serious consequences. So in the case of amoebic dysentery will be assigned a stronger antibiotics, the spectrum of side effects which are much wider than that of the drug that will make medical treatment more debilitating and long.

The pharmaceutical preparation can greatly affect motor coordination and fine motor skills, cause impaired consciousness, because while conservative treatment should be discarded from driving or other potentially dangerous machinery.

Analogs Dazolika

Match code ATC 4th level:

• Tiberal

Analogs Dazolika few, usually the therapeutic effect of the pharmaceutical preparation at any contraindications to its use protivoprotozoynymi replaced by the following means: Ornisidom or Avrazorom .

Synonyms

ATC code at the same Dazolika with little near pharmaceuticals: Ornidazole . Tiberalom . Ghayr .

Babies

The medicament may be used in pediatric practice since neonatal period   (known cases of infection of children vaginal Trichomonas   after passing the infected birth canal), but stringent prescribed dosage Dazolika as referring to a physiological imperfections excretory systems young organism possibility of overdose is significantly higher in children.

Dazolik and alcohol

Alcohol and ethanol metabolic products are compatible with a pharmaceutical preparation, its constituent components are not inhibit atsetaldegidrogenazu   and promote the accumulation of toxic substances, because there is no disulfiramopodobnyh reactions However drinking during the course of medical treatment as well as in combination with other antibiotics is not recommended.

During pregnancy and lactation

The drug is contraindicated for use during periods of Lactation and pregnancy Especially in the first trimester, as can irreversibly affect vital systems and organs of the developing baby.

Reviews Dazolike

Reviews on Dazolik forums on a variety of pharmaceutical predominantly positive character, because the antibiotic cope with harmful microorganisms in a short time and allows relatively quickly restore full ability to work and return to duty. Also, people who have been treated according to the pharmaceutical noted an unusually low number of adverse effects of therapy, which also appear not in all cases the conservative course of readjustment Dazolikom.

Almost for the same reasons the drug antiprotozoal action coveted physicians and therapeutic hospitals, pharmacists and qualified. Its safely administered in pediatric and adult, since the force of the effect of the antibiotic can cure a wide range of pathologies and destroy harmful microflora with minimal adverse reactions.

Also worth noting is that to achieve excessive plasma concentrations of active ingredients in the blood plasma difficult, because Dazolik has a wide scope of application, which can not give extra points to other antibiotics antiprotozoal character.

Price Dazolika where to buy

Price Dazolika in Russia is 260 rubles per pack, the price of pellets in Ukraine Dazolik pleases few more, because the drug can be bought for only 40-50 hryvnia.

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