Description overdue on 04/30/2014
- Latin name: Vero-Amlodipine
- ATC code: C08CA01
- Active substance: Amlodipine (Amlodipine)
- Manufacturer: OJSC "Veropharm", Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Vero Amlodipine (method and dosage)
- Overdose
- Cooperation
- Storage conditions
- Terms of sale
- Shelf life
- Cautions
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The tablet formulation contains Vero Amlodipine 5 (10 mg) amlodipine (as besylate ).
Product form
Tablets produced 10 pieces. in a blister pack in a cardboard packaging 1 or can contain 3 blisters.
Pharmacological action
Vero Amlodipine Tablets have antianginal and antihypertensive action.
Pharmacodynamics and pharmacokinetics
The drug impedes the flow of calcium ions across the membranes in the cells of blood vessels and the myocardium. Arterial pressure decreases as a result of vasodilatation. Antianginal effect provided amlodipine Which expands peripheral arterioles and reduces peripheral vascular resistance, without causing reflex tachycardia . This reduces myocardial oxygen demand, and the heart muscle uses less energy. Amlodipine helps to increase oxygen delivery to all areas of the myocardium when a coronary artery spasm.
After receiving well absorbed from the gastrointestinal tract (at the rate of absorption is not affected by food intake). After 6-12 hours, reaches a maximum blood concentration. Bioavailability - 65-80%. The liver transforms, forming inactive metabolites . Excreted through the kidneys (60%) and bowel (25%).
Indications
The drug is indicated for the following diseases:
- arterial hypertension (monotherapy or in combination with other drugs);
- vasoconstriction or vasospasm ;
- stable angina ;
- Dilated (non-ischemic) cardiomyopathy with stage III-IV chronic heart failure;
- vasospastic angina .
The drug should be administered as monotherapy or in combination with antianginal drugs to those patients who are resistant to therapy beta-blockers or nitrates .
Contraindications
The drug should not be taken at hypotension Children under 18 years of age and sensitivity amlodipine or other dihydropyridine .
Side effects
When you receive this medication may experience:
- tachycardia . arrhythmia . hyperemia , Palpitations, peripheral edema, breathlessness . hypotension ;
- gingival hyperplasia , Sharp abdominal pain, nausea;
- paresthesia . drowsiness , Fatigue, dizziness, headache;
- pruritus, rash.
In the long duration of the course can be a pain in the limbs.
Instructions for use Vero Amlodipine (method and dosage)
The drug, taken orally.
For patients with hypertension or angina the minimum daily dose is 5 mg. Later, if there is need to increase it can be up to 10 mg.
With dilated cardiomyopathy treatment should begin with a dose of 2, 5 mg, which increase at normal tolerability can be up to 10 mg.
According to the instructions exceed the dosage to 10 mg per day is not recommended, since it is the maximum.
Simultaneous reception with amlodipine beta-blockers . thiazide diuretics or ACE inhibitors does not require dose adjustments.
Overdose
Information on the symptoms of overdose are not available.
Cooperation
Antihypertensive effect may be enhanced when taken with calcium channel blockers . As a result can be observed when using means for inhalation anesthesia or Orlistat That can lead to a sharp increase in pressure, hypertensive crisis.
The delay in the body of sodium and, consequently, reduced antigipetrenzivnogo possible effect when taken with amlodimpinom estrogen and sympathomimetic . Reinforce antihypertensive effect can also using Amiodarone or quinidine .
Occurrence of neurotoxicity symptoms such as tinnitus, nausea, ataxia, diarrhea, vomiting, can be caused by taking Lithium carbonate together with Vero amlodipine.
Simultaneous treatment with amlodipine Indomethacin or other NSAIDs It reduces the antihypertensive effect.
Storage conditions
Store in a dark, dry place at a temperature of not more than 25 ° C.
Terms of sale
Sold without prescription.
Shelf life
2 years.
Cautions
The drug should be taken with caution aortic stenosis, and abuse renal function and liver .
No dosage adjustment in elderly patients is not required.
Amlodipine may be used for treatment of patients with dilated (non-ischemic) cardiomyopathy Which is accompanied by congestive heart failure.
During pregnancy and lactation
Security Vero amlodipine during breastfeeding or pregnancy has not been studied.
Assign the drug can only be the case if the risk for the child is less than the mother's health.
Reviews for Vero Amlodipine
Reviews patients suggest that the drug is an effective tool, which reduces the pressure, as well as improving overall well-being: an end headache . dizziness Absence weakness and fatigue .
Price Vero Amlodipine
In Russia, the price of the drug is about 72 rubles, in Ukraine - about 17 USD.
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